公开(公告)号：US4308867A

公开(公告)日：1982-01-05

申请号：US23125

申请日：1979-03-23

申请人： Theodore J. Roseman ,  Osmer S. Carpenter ,  Richard W. Baker ,  James W. Ayres

发明人： Theodore J. Roseman ,  Osmer S. Carpenter ,  Richard W. Baker ,  James W. Ayres

IPC分类号： A61K9/48 ,  A61F13/20 ,  A61K9/00 ,  A61K31/557 ,  A61M7/00

CPC分类号： A61F13/28 ,  A61F13/2051 ,  A61F13/2068 ,  A61F13/2074 ,  A61K31/557 ,  A61K9/0036 ,  A61F13/2011 ,  Y10S604/904

摘要： The present specification describes a medicated device adapted for a single and rate-controlled rectal or vaginal administration to a mammal of a systemically active pharmaceutical (SAP). The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the SAP from the device at the conclusion of the single, acute use. The device comprises three elements:(A) an inert resilient support means contoured for easy vaginal or rectal insertion;(B) a first flexible polymer film layer affixed to the support means and containing the SAP dispersed therethrough, this first polymer film not being rate limiting as to the release of drug from the device; and(C) a second polymer film, laminated onto the first polymer film and providing a release rate therefrom of prostaglandin, which is rate limiting both as to the release of prostaglandin from the device and absorption rate by the rectal or vaginal tissues.

摘要翻译： 本说明书描述了一种适用于单一和速率控制的直肠或阴道给药的药物装置，其用于系统活性药物（SAP）的哺乳动物。 该装置以基本上时间独立的剂量速率实现药物给药。 此外，该装置有利地导致在单次急性使用结束时SAP从装置中显着耗尽。 该装置包括三个元件：（A）易于阴道或直肠插入的惰性弹性支撑装置; （B）第一柔性聚合物膜层，其固定在支撑装置上并含有分散在其中的SAP，该第一聚合物膜不能限制药物从装置中的释放; 和（C）第二聚合物膜，层压在第一聚合物膜上并提供前列腺素的释放速率，前列腺素的释放速率限于前列腺素从装置中的释放和由直肠或阴道组织吸收的速率。

公开(公告)号：US4237888A

公开(公告)日：1980-12-09

申请号：US23126

申请日：1979-03-23

申请人： Theodore J. Roseman ,  Osmer C. Carpenter ,  Richard W. Baker ,  James W. Ayres

发明人： Theodore J. Roseman ,  Osmer C. Carpenter ,  Richard W. Baker ,  James W. Ayres

IPC分类号： A61F13/20 ,  A61K9/00 ,  A61K31/557

CPC分类号： A61F13/28 ,  A61F13/2051 ,  A61F13/2068 ,  A61F13/2074 ,  A61K31/557 ,  A61K9/0036 ,  A61F13/2011 ,  A61F2013/8414

摘要： The present specification describes a medicated device adapted for a single, acute, and rate-controlled rectal or vaginal administration to a mammal of a lipophilic prostaglandin. The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the prostaglandin from the device at the conclusion of the single, acute use. The device comprises three elements:(A) an inert resilient support means contoured for easy vaginal or rectal insertion;(B) a first flexible polymer film layer affixed to the support means and containing the prostaglandin dispersed therethrough, this first polymer film not being rate limiting as to the release of drug from the device; and(C) a second polymer film, laminated onto the first polymer film and providing a release rate therefrom of prostaglandin, which is rate limiting both as to the release of prostaglandin from the device and absorption rate by the rectal or vaginal tissues.

摘要翻译： 本说明书描述适用于对亲脂性前列腺素的哺乳动物的单次，急性和速率控制的直肠或阴道给药的药物装置。 该装置以基本上时间独立的剂量速率实现药物给药。 此外，该装置有利地导致在单次急性使用结束时来自装置的前列腺素的显着耗尽。 该装置包括三个元件：（A）易于阴道或直肠插入的惰性弹性支撑装置; （B）固定在支撑装置上并含有分散在其中的前列腺素的第一柔性聚合物膜层，该第一聚合物膜不限制药物从装置中的释放; 和（C）第二聚合物膜，层压在第一聚合物膜上并提供前列腺素的释放速率，前列腺素的释放速率限于前列腺素从装置中的释放和由直肠或阴道组织吸收的速率。

公开(公告)号：US4043339A

公开(公告)日：1977-08-23

申请号：US654486

申请日：1976-02-02

申请人： Theodore J. Roseman

发明人： Theodore J. Roseman

IPC分类号： A61K9/00 ,  A61M31/00 ,  A61M7/00

CPC分类号： A61M31/002 ,  A61K9/0036

摘要： Novel vaginal devices containing prostaglandins and intended for use in accomplishing abortion in women in the first and second trimester of pregnancy and in inducing labor in pregnant women at or near term.

摘要翻译： 新颖的阴道装置含有前列腺素，旨在用于在怀孕的第一和第二个孕期进行妇女堕胎，并在短期或近期诱发孕妇的劳动。

公开(公告)号：US4402693A

公开(公告)日：1983-09-06

申请号：US376798

申请日：1982-05-10

申请人： Theodore J. Roseman ,  Glenford R. Derr ,  Gilbert Schwartzman

发明人： Theodore J. Roseman ,  Glenford R. Derr ,  Gilbert Schwartzman

IPC分类号： A61M31/00 ,  A61F13/20

CPC分类号： A61M31/002

摘要： A medicated device comprises a substantially cylindrical, hollow body member having radially outwardly extending annular ridges at each end, a lengthwise slot, and inwardly extending flanges along the edges of the slot which have concave facing surfaces. A multi-layer, drug-bearing sheet material extends around the cylindrical member between and adjacent the annular ridges and has edge portions which extend into the slot. A cylindrical rod is disposed between the concave surfaces to clamp the sheet edge portions in the slot against the concave surfaces. End caps are mounted on each end of the cylindrical member, and each has a radially inwardly extending ridge which presses an adjacent edge of the sheet material against the cylindrical member.

摘要翻译： 药物装置包括基本上圆柱形的中空本体构件，其在每个端部处具有径向向外延伸的环形脊，纵向狭槽和沿着凹槽的边缘的向内延伸的凸缘，其具有凹面对面。 多层药物承载片材在环形脊之间和邻近环形脊之间围绕圆柱形构件延伸并且具有延伸到槽中的边缘部分。 圆柱形杆设置在凹面之间，以将板边缘部分夹在槽中抵靠凹面。 端盖安装在圆柱形构件的每个端部上，并且每个端盖具有径向向内延伸的脊部，其将片材的相邻边缘压靠在圆柱形构件上。