-
公开(公告)号：US07008926B2
公开(公告)日：2006-03-07
申请号：US10468111
申请日：2002-02-07
申请人： Paul D. Bishop
发明人： Paul D. Bishop
IPC分类号： A61K38/00
CPC分类号： A61K38/45
摘要： Use of factor XIII for treating the symptoms of thrombocytopenia. A patient having thrombocytopenia, either chemically- or metabolically induced, is treated by administering factor XIII.
摘要翻译： 使用因子XIII治疗血小板减少症状。 化学或代谢诱导的具有血小板减少症的患者通过施用因子XIII治疗。
-
公开(公告)号：US06979445B2
公开(公告)日：2005-12-27
申请号：US10468113
申请日：2002-02-07
申请人： Paul D. Bishop
发明人： Paul D. Bishop
CPC分类号： A61K38/45 , A61K2300/00
摘要： Use of factor XIII for treating von Willebrand's disease. A patient having von Willebrand's disease is treated by administering factor XIII generally in conjunction with factor VIII concentrate, 1-desamino-8-D-arginine vasopressin (DDAVP) or desmopressin.
摘要翻译： 使用因子XIII治疗血管性血友病。 通常通过与因子VIII浓缩物，1-脱氨基-8-D-精氨酸加压素（DDAVP）或去氨加压素联合施用因子XIII来治疗患有维勒布兰氏病的患者。
-
公开(公告)号：US06828425B2
公开(公告)日：2004-12-07
申请号：US10212355
申请日：2002-08-02
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
IPC分类号： C07K1600
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供了两个称为“Zven”的人类蛋白质家族的成员。 位于人染色体3p21.1-3p14.3中的Zven1基因在睾丸组织和外周血淋巴细胞中表达。
-
公开(公告)号：US06521233B1
公开(公告)日：2003-02-18
申请号：US09552225
申请日：2000-04-19
IPC分类号： C07K1400
CPC分类号： C07K14/472 , A61K38/00 , C07K14/4702 , C07K2319/02
摘要： The present invention relates to polynucleotide and polypeptide molecules for zacrp3, a novel member of the family of proteins bearing a collage-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp3 polypeptides.
摘要翻译： 本发明涉及用于zacrp3的多核苷酸和多肽分子，其是具有拼贴样结构域和C1q结构域的蛋白家族的新成员。 编码它们的多肽和多核苷酸参与二聚化或低聚反应，并可用于其研究。 本发明还包括针对zacrp3多肽的抗体。
-
公开(公告)号：US06485938B1
公开(公告)日：2002-11-26
申请号：US09712529
申请日：2000-11-14
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
IPC分类号： C12P2106
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供了两个称为“Zven”的人类蛋白质家族的成员。 位于人染色体3p21.1-3p14.3中的Zven1基因在睾丸组织和外周血淋巴细胞中表达。
-
公开(公告)号：US06448221B1
公开(公告)日：2002-09-10
申请号：US09506855
申请日：2000-02-17
IPC分类号： C07K100
CPC分类号： A61K38/1709
摘要： The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacifying collagenous surfaces and modulating wound healing.
摘要翻译： 本发明涉及用作止血和免疫功能抑制剂的多核苷酸和多肽分子。 这种抑制剂是具有胶原样结构域和球状结构域的蛋白家族的成员。 抑制剂可用于通过降低血栓形成和补体活性来促进脉管系统中的血液流动。 抑制剂也可用于平缓胶原表面和调节伤口愈合。
-
公开(公告)号：US06380164B1
公开(公告)日：2002-04-30
申请号：US09767657
申请日：2001-01-23
IPC分类号： A61K3808
CPC分类号： A61K38/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/893 , Y10S514/894 , Y10S514/937
摘要： A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
摘要翻译： 通过向哺乳动物施用deltorphins来调节细胞因子介导的肝损伤的方法。 Deltorphin I SEQ ID NO：1，deltorphin II SEQ ID NO：2或deltorphins I SEQ ID NO：1和II SEQ ID NO：2的组合可以施用。 在生理上可接受的制剂中，约0.5mg / kg至约20mg / kg范围内的delphphin浓度阻断脓毒性休克鼠模型中的细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。
-
公开(公告)号：US06294519B1
公开(公告)日：2001-09-25
申请号：US09702305
申请日：2000-10-31
申请人： Peter R. Oeltgen , Mark S. Kindy , Paul D. Bishop
发明人： Peter R. Oeltgen , Mark S. Kindy , Paul D. Bishop
IPC分类号： A01N3718
摘要： A method for treating ischemia by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, delntorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration of about 0.5-20 mg/kg body weight, or alternatively a lower concentration of about 1-1000 &mgr;g/kg body weight of the mammal in a physiologically acceptable formulation is administered up to four hours after an ischemic episode. Deltorphins may also be administered prior to or concurrently with onset of ischemia. Cerebral or spinal cord ischemia or ischemic heart disease may be treated using the method of the invention.
摘要翻译： 一种通过向哺乳动物施用去铁蛋白来治疗缺血的方法。 可以给予Deltorphin I SEQ ID NO：1，delntorphin II SEQ ID NO：2或deltorphins I SEQ ID NO：1和II SEQ ID NO：2的组合。 在缺血发作后4小时内给药约0.5-20mg / kg体重的滴度，或者在生理上可接受的制剂中哺乳动物的约1-1000μg/ kg体重的较低浓度。 去头痛也可以在缺血发作之前或同时发生。 可以使用本发明的方法治疗脑或脊髓缺血或缺血性心脏病。
-
公开(公告)号：US07977309B2
公开(公告)日：2011-07-12
申请号：US12075821
申请日：2008-03-13
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
-
50.发明申请MEDICAL DEVICES FOR DELIVERING FLUIDS DURING SURGERY AND METHODS FOR THEIR USE 有权用于在手术期间输送流体的医疗装置及其使用方法公开(公告)号：US20110166550A1
公开(公告)日：2011-07-07
申请号：US12988353
申请日：2009-04-27
CPC分类号： A61B17/00234 , A61B17/00491 , A61B2017/00004 , A61B2017/00473 , A61B2017/00495 , A61B2017/0065 , A61B2017/00654 , A61B2017/320044 , A61B2090/3966
摘要： Provided is a surgical applicator and applicator tip configured to attach in fluid communication, for the delivery of beneficial fluids. The applicator tip may also be configured to reversibly attach, in fluid communication, with a pledget. For example, the applicator tip may include male or female threads, and the pledget has threads that are complementary to the thread configuration of the tip. The applicator tip may further comprise at least one fluid transfer lumen for transfer of a fluid from the tip to the pledget. In one embodiment of the invention, the tip includes male threads and the pledget includes a pledget attachment portion. There are also provided methods for connecting the tip to the pledget. In one embodiment, a tip comprising male threads is attached to the pledget, comprising a pledget attachment portion, by tapping or pressing the tip into the pledget attachment portion. There are also provided methods of use for the attached tip and pledget, including debridement, tissue translocation, delivery of fluid substances, absorption of fluid substances and combinations thereof. In a particular embodiment, the applicator places a thrombin solution into the attached pledget for delivery of an active hemostatic agent to a tissue site.
摘要翻译： 提供了一种外科施用器和施用器尖端，其构造成附接在流体连通中，用于输送有益的流体。 施用器尖端还可以被配置成以流体连通的方式可逆地附接于毛细管。 例如，施用器尖端可以包括阳螺纹或阴螺纹，并且毛细管具有与尖端的螺纹构造互补的螺纹。 施用器尖端可以进一步包括至少一个流体传送腔，用于将流体从尖端传送到毛细管。 在本发明的一个实施例中，尖端包括阳螺纹，并且所述毛细管件包括毛细管连接部分。 还提供了将尖端连接到材料的方法。 在一个实施例中，包括外螺纹的尖端通过将尖端敲入或挤压到毛细管连接部分中而附着到毛细管，包括毛细管附着部分。 还提供了用于附着的尖端和毛细管的方法，包括清创，组织易位，流体物质的输送，流体物质的吸收及其组合。 在一个具体实施方案中，施用器将凝血酶溶液放置在附着的药剂中，以将活性止血剂递送至组织部位。
-
-
-
-
-
-
-
-
-
搜索结果
62 条记录 (耗时 0.049 秒)
