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公开(公告)号：US20090270333A1
公开(公告)日：2009-10-29
申请号：US12075821
申请日：2008-03-13
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
IPC分类号： A61K38/10 , C07H21/04 , C12N15/63 , C12N5/10 , C07K7/08 , C07K14/00 , C07K16/00 , C12P21/00 , A61P1/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
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公开(公告)号：US06838438B2
公开(公告)日：2005-01-04
申请号：US09794987
申请日：2001-02-27
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
IPC分类号： A61K38/00 , C07K14/575 , A61K38/10 , C07K7/08 , C07K14/63
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
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公开(公告)号：US07977309B2
公开(公告)日：2011-07-12
申请号：US12075821
申请日：2008-03-13
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
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公开(公告)号：US06939690B2
公开(公告)日：2005-09-06
申请号：US09796158
申请日：2001-02-28
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
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公开(公告)号：US20080194484A1
公开(公告)日：2008-08-14
申请号：US12009230
申请日：2008-01-16
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
摘要翻译： 本发明涉及用于标记为TML肽的新型肽片段的多核苷酸，肽，变体及其用途。 肽片段的结合已显示在肾脏和小肠中。 本发明还包括激动剂，拮抗剂，变体，抗体，表达编码新型TML肽的cDNA的宿主细胞和使用新型TML肽增加消化蛋白和激素的胃动力和分泌的方法。
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公开(公告)号：US06897286B2
公开(公告)日：2005-05-24
申请号：US09853253
申请日：2001-05-10
IPC分类号： A61K38/00 , C07K14/575 , C07K14/63 , C12N9/00 , C12N15/00
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to peptides related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33肽相关的肽，包括激动剂，拮抗剂和抗体。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US06627729B1
公开(公告)日：2003-09-30
申请号：US09404417
申请日：1999-09-23
IPC分类号： C07K706
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
摘要翻译： 本发明涉及用于标记为TML肽的新型肽片段的多核苷酸，肽，变体及其用途。 肽片段的结合已经显示在肾脏和小肠中。 本发明还包括激动剂，拮抗剂，变体，抗体，表达编码新型TML肽的cDNA的宿主细胞和使用新型TML肽增加消化蛋白和激素的胃动力和分泌的方法。
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公开(公告)号：US07354739B2
公开(公告)日：2008-04-08
申请号：US10607706
申请日：2003-06-27
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
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公开(公告)号：US06420521B1
公开(公告)日：2002-07-16
申请号：US09608810
申请日：2000-06-30
IPC分类号： G01N3353
CPC分类号： C07K7/06 , A61K38/00 , C07K14/47 , C07K14/575 , C07K14/63
摘要： The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel Short Gastrointestinal Peptides (SGIP) peptide.
摘要翻译： 本发明涉及与胃动素同源的新型肽片段的多核苷酸，多肽，肽，变体和用途。 新型多肽片段的mRNA的组织分布特异于胃，小肠和胰腺。 肽片段的结合已显示在肾脏和小肠中。 本发明还包括表达编码新型短胃肠肽（SGIP）肽的cDNA的激动剂，拮抗剂，变体，抗体和宿主细胞。
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公开(公告)号：US07135317B2
公开(公告)日：2006-11-14
申请号：US09809617
申请日：2001-03-15
IPC分类号： C12N9/00
CPC分类号： C12N9/6489 , C07K14/47
摘要： The present invention relates to human polynucleotide and polypeptide molecules for zdint1, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are believed to be cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the zdint1 polypeptides.
摘要翻译： 本发明涉及用于zdint1的人多核苷酸和多肽分子，其是解聚酶蛋白酶的新成员。 多肽和编码它们的多核苷酸被认为是细胞 - 细胞相互作用调节，并可用于递送和治疗。 本发明还包括针对zdint1多肽的抗体。
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