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公开(公告)号：US4401592A
公开(公告)日：1983-08-30
申请号：US321486
申请日：1981-11-16
申请人： Chikao Yoshikumi , Takayoshi Fujii , Masahiko Fujii , Kenichi Matsunaga , Yoshiharu Oguchi , Koichi Niimura
发明人： Chikao Yoshikumi , Takayoshi Fujii , Masahiko Fujii , Kenichi Matsunaga , Yoshiharu Oguchi , Koichi Niimura
CPC分类号： A61K47/48407 , Y10S530/806 , Y10S530/812 , Y10S530/813
摘要： Disclosed is a novel pharmaceutical composition having antitumor (anti-cancer) activity without causing pyrexia and anaphylaxis, formed by an amide bonding between an antibody obtained by the purification of the antibody to tumor (cancer) antigen via affinity-chromatography and an antitumor substance (anti-cancer drug).
摘要翻译： 公开了一种具有抗肿瘤（抗癌）活性的新型药物组合物，其不引起发热和过敏反应，通过通过亲和层析纯化抗体获得的抗体与抗肿瘤物质（癌症） 抗癌药）。
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42.发明授权Pharmaceutical composition containing 24,25-dihydroxycholecalciferol as an active ingredient to treat myodystrophia 失效含有24,25-二羟基胆钙化甾醇作为活性成分以治疗肌营养不良症的药物组合物
公开(公告)号：US4501737A
公开(公告)日：1985-02-26
申请号：US620922
申请日：1984-06-15
申请人： Hideyuki Yamato , Noriyuki Toyoda , Takayoshi Fujii , Yuji Maeda , Tadaaki Kato , Chikao Yoshikumi
发明人： Hideyuki Yamato , Noriyuki Toyoda , Takayoshi Fujii , Yuji Maeda , Tadaaki Kato , Chikao Yoshikumi
CPC分类号： A61K31/59
摘要： Disclosed is a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of myodystrophia of a compound of 24,25-dihydroxycholecalciferol and a pharmaceutical acceptable carrier or diluent therefor.
摘要翻译： 公开了一种剂量单位形式的药物组合物，其包含有效治疗24,25-二羟基胆钙化甾醇化合物和其药学上可接受的载体或稀释剂的肌营养不良的剂量。
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43.发明授权Method for inhibiting the formation of urinary calculus utilizing 24,25-(OH).sub.2 -D.sub.3 失效利用24,25-（OH）2-D3抑制尿结石形成的方法
公开(公告)号：US4866047A
公开(公告)日：1989-09-12
申请号：US103788
申请日：1987-10-01
申请人： Hideyuki Yamato , Yuji Maeda , Takayoshi Fujii , Yasuhiko Kobayashi , Kenichi Saito , Fumio Hirose , Tadaaki Kato , Chikao Yoshikumi
发明人： Hideyuki Yamato , Yuji Maeda , Takayoshi Fujii , Yasuhiko Kobayashi , Kenichi Saito , Fumio Hirose , Tadaaki Kato , Chikao Yoshikumi
CPC分类号： A61K31/59 , Y10S514/891
摘要： Disclosed herein is a method for inhibiting the formation of urinary calculus by the administration of 24,25-dihydroxycholecarciferol.
摘要翻译： 本文公开了通过施用24,25-二羟基胆碱酯抑制尿结石形成的方法。
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公开(公告)号：US4851395A
公开(公告)日：1989-07-25
申请号：US163238
申请日：1988-02-26
申请人： Saburo Ueno , Chikao Yoshikumi , Yoshio Omura , Takayoshi Fujii , Toshihiko Wada , Eiichi Takahashi , Fumio Hirose
发明人： Saburo Ueno , Chikao Yoshikumi , Yoshio Omura , Takayoshi Fujii , Toshihiko Wada , Eiichi Takahashi , Fumio Hirose
CPC分类号： C12P21/005 , A61K36/07
摘要： Disclosed is nitrogen-containing polysaccharide substantially free of units having a molecular weight below about 5,000, said nitrogen-containing polysaccharide having been extracted from Coriolus versicolor (Fr.) Quel., substantially all polymer units having a molecular weight below about 5,000 having been removed therefrom, which exhibits antitumor and immunological activity.
摘要翻译： 公开了基本上不含分子量低于约5,000的单元的含氮多糖，所述含氮多糖已从Coriolus versicolor（Fr.）Quel提取，基本上分子量低于约5,000的聚合物单元已经被除去 其具有抗肿瘤和免疫活性。
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公开(公告)号：US4372890A
公开(公告)日：1983-02-08
申请号：US265838
申请日：1981-05-21
CPC分类号： C07F15/0093
摘要： The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.
摘要翻译： 本发明涉及具有式（1）的铂化合物，其中R表示氢原子，碱金属原子或低级烷基。 铂化合物作为抗肿瘤和抗菌药物是有效的。
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公开(公告)号：US4051314A
公开(公告)日：1977-09-27
申请号：US513958
申请日：1974-10-11
申请人： Shigeto Ohtsuka , Saburo Ueno , Chikao Yoshikumi , Fumio Hirose , Yoshio Ohmura , Toshihiko Wada , Takayoshi Fujii , Eiichi Takahashi
发明人： Shigeto Ohtsuka , Saburo Ueno , Chikao Yoshikumi , Fumio Hirose , Yoshio Ohmura , Toshihiko Wada , Takayoshi Fujii , Eiichi Takahashi
IPC分类号： A61K31/715 , A61K36/07 , A61K36/899 , C08B37/00 , C12P19/04
CPC分类号： C12P19/04 , A61K31/715 , A61K36/07 , A61K36/899 , C08B37/006 , Y10S435/803 , Y10S435/911
摘要： Polysaccharides are produced by purifying a liquid extract of a mycelium of a strain of fungus species belonging to the class Basidiomycetes or the filtered broth of a cultured medium in which a mycelium of a selected strain of Basidiomycetes has been incubated; the polysaccharides exhibiting an anticarcinogenic activity in mice.
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公开(公告)号：US4925662A
公开(公告)日：1990-05-15
申请号：US143747
申请日：1988-01-14
申请人： Yoshiharu Oguchi , Koichi Niimura , Takayoshi Fujii , Masahiko Fujii , Kenichi Matsunaga , Chikao Yoshikumi
发明人： Yoshiharu Oguchi , Koichi Niimura , Takayoshi Fujii , Masahiko Fujii , Kenichi Matsunaga , Chikao Yoshikumi
IPC分类号： A61K31/195 , A61K39/395 , A61K47/48 , A61P35/00
CPC分类号： A61K39/395 , A61K47/48384 , Y10S424/809 , Y10S530/866
摘要： Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.
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48.发明授权Antiosteoporotic pharmaceutical composition containing 24,25-dihydroxycholecalciferol as an active ingredient 失效含有24,25-二羟基胆钙化甾醇作为活性成分的抗骨质疏松药物组合物
公开(公告)号：US4590184A
公开(公告)日：1986-05-20
申请号：US662044
申请日：1984-10-18
申请人： Yuji Maeda , Hideyuki Yamato , Takayoshi Fujii , Yasuhiko Kobayashi , Kenichi Saito , Tadaaki Kato , Chikao Yoshikumi
发明人： Yuji Maeda , Hideyuki Yamato , Takayoshi Fujii , Yasuhiko Kobayashi , Kenichi Saito , Tadaaki Kato , Chikao Yoshikumi
CPC分类号： A61K31/59
摘要： Disclosed herein is a pharmaceutical composition in dosage unit form, which comprises a dosage effective for treating osteoporosis of a compound of 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
摘要翻译： 本文公开了一种剂量单位形式的药物组合物，其包含有效治疗24,25-二羟基胆钙化甾醇和药学上可接受的载体的化合物的骨质疏松症的剂量。
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公开(公告)号：US4504487A
公开(公告)日：1985-03-12
申请号：US431374
申请日：1982-09-30
CPC分类号： C07F15/0093
摘要： The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.
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50.发明授权Method for administering 24,25-dihydroxycholecalciferol to persons suffering from hypercalcemia 失效将24,25-二羟基胆钙化醇给予患有高钙血症的人的方法
公开(公告)号：US4442093A
公开(公告)日：1984-04-10
申请号：US374702
申请日：1982-05-04
申请人： Yuji Maeda , Takayoshi Fujii , Yasuhiko Kobayashi , Kenichi Saito , Tadaaki Kato , Chikao Yoshikumi
发明人： Yuji Maeda , Takayoshi Fujii , Yasuhiko Kobayashi , Kenichi Saito , Tadaaki Kato , Chikao Yoshikumi
IPC分类号： A61K31/59
CPC分类号： A61K31/59 , Y10S514/866 , Y10S514/885 , Y10S514/908 , Y10S514/926 , Y10S514/927
摘要： Pharmaceutical composition in dosage unit form, comprising a therapeutically effective amount of 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier. The compound of 24,25-dihydroxycholecalciferol has anti-hypercalcemic activity, anti-ulcer activity, activity of preventing reduction of immunity, activity of controlling magnesium-metabolism, anti-hyperphosphatemic activity, activity of controlling blood sugar level and anti-tumor activity.
摘要翻译： 药物组合物，其剂量单位形式包括治疗有效量的24,25-二羟基胆钙化甾醇和药学上可接受的载体。 24,25-二羟基胆钙化甾醇的化合物具有抗高钙血症活性，抗溃疡活性，防止免疫力降低的活性，控制镁代谢活性，抗高磷血症活性，控制血糖水平和抗肿瘤活性的活性。
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