公开(公告)号：US20160341737A1

公开(公告)日：2016-11-24

申请号：US15167513

申请日：2016-05-27

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: G01N33/58 ,  C09K11/06 ,  C09K11/02 ,  C08J3/11 ,  C08G61/12

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US20150037259A1

公开(公告)日：2015-02-05

申请号：US14373835

申请日：2013-02-01

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Yuhui Jin ,  Fangmao Ye ,  Changfeng Wu ,  Yang-Hsiang Chan

IPC: G01N33/58 ,  A61K49/00

CPC classification number: G01N33/588 ,  A61K49/0065 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  H01L51/0036 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/5012

Abstract: Polymer nanoparticles and related methods include polymer dots having a coating including a polyelectrolyte polymer. The polymer dots can have a polyelectrolyte coating that can improve colloidal stability of the particles as compared to polymer dots not having the coating. A method of preparing a population of nanoparticles. The methods can include, e.g., providing the population of nanoparticles having a condensed semiconducting polymer; and combining, in a first aqueous solution comprising polyelectrolytes, the population of nanoparticles having the condensed semiconducting polymer to form a population of nanoparticles having a polyelectrolyte coating surrounding the condensed semiconducting polymer of each of the nanoparticles in the population. The methods can include a step of forming the condensed semiconducting polymer using nanoprecipitation or miniemulsion techniques. The polyelectrolyte coating can completely surround the condensed semiconducting polymer.

Abstract translation: 聚合物纳米粒子和相关方法包括具有包括聚电解质聚合物的涂层的聚合物点。 与不具有涂层的聚合物点相比，聚合物点可以具有可以改善颗粒的胶体稳定性的聚电解质涂层。 一种制备纳米颗粒群体的方法。 所述方法可以包括例如提供具有冷凝的半导体聚合物的纳米颗粒群; 并且在包含聚电解质的第一水溶液中混合具有所述缩合的半导体聚合物的纳米颗粒群以形成纳米颗粒群，所述纳米颗粒群包含围绕群体中每个纳米颗粒的缩合半导体聚合物的聚电解质涂层。 该方法可以包括使用纳米沉淀或微乳液技术形成冷凝的半导体聚合物的步骤。 聚电解质涂层可以完全包围冷凝的半导体聚合物。