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    1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
    41.
    发明授权
    1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders 失效
    用于治疗炎症和炎症相关疾病的1,4,5-三苯基吡唑基化合物

    公开(公告)号：US5401765A

    公开(公告)日：1995-03-28

    申请号：US161004

    申请日：1993-11-30

    申请人： Len F. Lee

    发明人： Len F. Lee

    IPC分类号： A61K31/415 ,  A61P25/04 ,  A61P29/00 ,  C07D231/12 ,  C07D231/14

    CPC分类号： C07D231/12 ,  A61K31/415

    摘要： A class of 1,4,5-triphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I ##STR1## wherein R.sup.1 is one or more groups independently selected from hydrido, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl, methylsulfonyl, hydroxy, nitro, amino, N-methylamino, acetamido, trifluoromethyl, bromo, iodo, fluoro and chloro; wherein R.sup.2 is selected from hydrido, methyl, ethyl, cyano, trifluoromethyl, difluorochloromethyl, difluoromethyl, pentafluoroethyl and heptafluoropropyl; wherein R.sup.3 is one or more groups independently selected from hydrido, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl, methylsulfonyl, hydroxy, nitro, amino, N-methylamino, acetamido, trifluoromethyl, bromo, iodo, fluoro and chloro; and wherein R.sup.4 is methyl; or a pharmaceutically-acceptable salt thereof.

    摘要翻译： 描述了一类1,4,5-三苯基吡唑用于治疗炎症，包括治疗疼痛和疾病如关节炎。 特别感兴趣的化合物是式I其中R 1是一个或多个独立地选自氢，甲基，乙基，甲氧基，乙氧基，甲硫基，甲基亚磺酰基，甲基磺酰基，羟基，硝基，氨基，N-甲基氨基，乙酰氨基， 三氟甲基，溴，碘，氟和氯; 其中R2选自氢，甲基，乙基，氰基，三氟甲基，二氟氯甲基，二氟甲基，五氟乙基和七氟丙基; 其中R3是一个或多个独立地选自氢，甲基，乙基，甲氧基，乙氧基，甲硫基，甲基亚磺酰基，甲基磺酰基，羟基，硝基，氨基，N-甲基氨基，乙酰氨基，三氟甲基，溴，碘，氟和氯的基团。 并且其中R 4是甲基; 或其药学上可接受的盐。