公开(公告)号：US4198402A

公开(公告)日：1980-04-15

申请号：US892918

申请日：1978-04-03

申请人： Elemer Ezer ,  Laszio Szporny ,  Lilla Forgach ,  Eva Palosi ,  Eszter Cholnoky ,  Egon Karpati ,  Gyorgy Hajos ,  Gyozo Hortobagyi ,  Katalin Gidai

发明人： Elemer Ezer ,  Laszio Szporny ,  Lilla Forgach ,  Eva Palosi ,  Eszter Cholnoky ,  Egon Karpati ,  Gyorgy Hajos ,  Gyozo Hortobagyi ,  Katalin Gidai

IPC分类号： A61K31/62

CPC分类号： A61K31/60

摘要： Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of phenylbutazone by using it in a composition of 1 part of antiphlogistic to 0.2 to 50 parts by weight of alkali metal salicylate.

摘要翻译： 通过使用0.1重量份碱金属水杨酸盐的1份消炎剂的组合物，可以预防在使用溃疡形成量的保泰松药物的长时间消炎治疗期间对动物的溃疡产生。

公开(公告)号：US3988322A

公开(公告)日：1976-10-26

申请号：US481466

申请日：1974-06-20

申请人： Tibor Kekesy ,  Szabolcs Szeberenyi ,  Gyorgy Beer ,  Antal Dudas ,  Gyorgy Hajos ,  Laszlo Szporny ,  Eva Czajlik nee Csizer

发明人： Tibor Kekesy ,  Szabolcs Szeberenyi ,  Gyorgy Beer ,  Antal Dudas ,  Gyorgy Hajos ,  Laszlo Szporny ,  Eva Czajlik nee Csizer

IPC分类号： C07J31/00 ,  A61K31/585 ,  A61P39/02 ,  C07J21/00

CPC分类号： C07J21/00

摘要： Pharmaceutically active steroids of the formula (I) ##SPC1##whereinX.sub.1 and X.sub.2 each is hydrogen, mercapto or acetylthio andX.sub.3 and X.sub.4 each is hydrogen or acetylthio orX.sub.3 and X.sub.4 form together a valence bond, with the proviso that at least one of X.sub.1 to X.sub.4 is selected from the group consisting of mercapto and acetylthio. The compounds are prepared as follows: a compound of the formula (III) ##SPC2##wherein Z.sub.1 is hydrogen and Z.sub.2 is hydrogen or acetylthio or Z.sub.1 and Z.sub.2 form together a valence bond, is brominated, the thus-obtained compound of the formula ##SPC3##Wherein Y.sub.1 and Y.sub.2 each is hydrogen or bromine, Y.sub.3 is bromine, Y.sub.4 is hydrogen or acetylthio or Y.sub.3 and Y.sub.4 form together a valence bond, is reacted with an alkali methal thioacetate or with an alkali metal hydrosulphide. Thioacetic acid can be coupled onto the obtained product, and/or optionally the obtained thioacetyl compound can be subjected to alcoholysis.The compounds of the formula (I) can be used in the prevention or treatment of poisoning caused by mercury or by other heavy metals.

摘要翻译： 式（I）的药学活性类固醇，其中X 1和X 2各自为氢，巯基或乙酰硫基，X 3和X 4各自为氢或乙酰硫基，或者X 3和X 4一起形成价键，条件是X 1至X 4中的至少一个 选自巯基和乙酰硫基。 化合物如下制备：其中Z 1为氢且Z 2为氢或乙酰硫基或Z 1和Z 2一起形成价键的式（III）化合物被溴化，由此获得的式WHEREIN Y1和Y2的化合物 各自为氢或溴，Y 3为溴，Y 4为氢或乙酰硫基或Y 3和Y 4一起形成价键，与硫代乙酸碱金属或与碱金属硫化氢反应。 硫代乙酸可以偶联到所得产物上，和/或任选得到的硫代乙酰基化合物可以进行醇解。