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    PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME
    52.
    发明申请
    PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME 有权
    含有量子纳米粒子的全氟烷纳米乳液及其制备方法

    公开(公告)号：US20100233094A1

    公开(公告)日：2010-09-16

    申请号：US12738394

    申请日：2008-08-20

    申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Bang Sil Choi ,  Jung Hyun Han

    发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Bang Sil Choi ,  Jung Hyun Han

    IPC分类号： A61B5/055

    CPC分类号： C09K11/565 ,  C09K11/02 ,  C09K11/883

    摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.

    摘要翻译： 本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能 量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。 所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。 因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

    SILICA CAPSULES HAVING NANO-HOLES OR NANO-PORES ON THEIR SURFACES AND METHOD FOR PREPARING THE SAME
    53.
    发明申请
    SILICA CAPSULES HAVING NANO-HOLES OR NANO-PORES ON THEIR SURFACES AND METHOD FOR PREPARING THE SAME 审中-公开
    在其表面上具有纳米孔或纳米孔的二氧化硅颗粒及其制备方法

    公开(公告)号：US20100040693A1

    公开(公告)日：2010-02-18

    申请号：US12376798

    申请日：2007-08-01

    申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim

    发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim

    IPC分类号： A61K9/14 ,  B32B5/16 ,  H01F1/00 ,  G02F1/361 ,  A61K38/43 ,  A61K38/02 ,  C09K11/06

    CPC分类号： B01J13/02 ,  A61K9/5115 ,  A61K9/5192 ,  Y10T428/2982

    摘要： The present invention relates to silica capsules having nano-holes or nano-pores on the surface thereof, and preparation methods thereof. More specifically, relates to silica capsules having holes with a size ranging from a few nanometers (nm) to a few hundreds of nanometers (nm), on the surface thereof, multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles, and preparation methods thereof. According to the present invention, the silica capsules having holes on the surface thereof can be prepared by making an emulsion system using two fluids having different surface tensions, and selectively evaporating only one fluid of the two fluids during a process of forming a silica layer. In addition, the multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles can be prepared by loading various multifunctional nanoparticles into the two fluids.

    摘要翻译： 本发明涉及在其表面具有纳米孔或纳米孔的二氧化硅胶囊及其制备方法。 更具体地，涉及具有尺寸范围从几纳米（nm）到几百纳米（nm）的孔的二氧化硅胶囊，其表面上含有磁性纳米颗粒和光学纳米颗粒的多功能硅胶胶囊及其制备方法。 根据本发明，其表面上具有孔的二氧化硅胶囊可以通过制备使用具有不同表面张力的两种流体的乳液体系，并且在形成二氧化硅层的过程中仅选择性地蒸发两种流体的一种流体来制备。 另外，含有磁性纳米粒子和光学纳米粒子的多功能二氧化硅胶囊可以通过将各种多功能纳米粒子加载到两种流体中来制备。

    High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby
    54.
    发明申请
    High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby 审中-公开
    通过筛选caspase3和XIAP结合抑制剂之间的结合抑制剂的高通量筛选方法

    公开(公告)号：US20090318376A1

    公开(公告)日：2009-12-24

    申请号：US12304766

    申请日：2006-06-12

    申请人： Bong Hyun Chung ,  Kwang-Hee Son ,  Moonil Kim ,  Kyoungsook Park ,  Byoung-Mog Kwon ,  Hyun Jung Junn ,  Dong Cho Han ,  Sun-Hee Jeon

    发明人： Bong Hyun Chung ,  Kwang-Hee Son ,  Moonil Kim ,  Kyoungsook Park ,  Byoung-Mog Kwon ,  Hyun Jung Junn ,  Dong Cho Han ,  Sun-Hee Jeon

    IPC分类号： A61K31/702 ,  G01N33/573 ,  C07H15/24

    CPC分类号： A61K31/702 ,  G01N33/574 ,  G01N2333/96469 ,  G01N2500/02

    摘要： The present invention relates to a high throughput screening method of a binding inhibitor between caspase3 and xIAP and chromomycin screened using the same, and more specifically, the present invention provides a method for screening anticancer substance, the method comprising the steps of reacting caspase3 or xIAP and candidate inhibitors of the binding between caspase3 and xIAP on a biochip for detecting caspase3:xIAP interaction, and selecting a candidate substance inhibiting the binding of caspase3 to xIAP as an anticancer substance, and an anticancer agent inhibiting caspase3:xIAP binding, which is screened by the above method. According to present invention, it is possible to develop a target-oriented anticancer agent focused on xIAP and caspase3, apoptosis-related proteins and thus it can be applied to tailored medication and combination therapy. Moreover, glycoside antibiotic chromomycin, screened by the present invention has inhibitory activity of the binding between xIAP and caspase3 involved in apoptosis, so that it can be used as a therapeutic agent for myelogenous leukemia and solid tumors.

    摘要翻译： 本发明涉及使用其筛选的胱天蛋白酶3和xIAP之间的结合抑制剂的高通量筛选方法，更具体地说，本发明提供了筛选抗癌物质的方法，所述方法包括以下步骤：使半胱天冬酶3或xIAP 以及用于检测胱天蛋白酶3：xIAP相互作用的生物芯片上的半胱天冬酶3和xIAP之间的结合的候选抑制剂，并且选择抑制半胱天冬酶3与作为抗癌物质的xIAP的结合的候选物质，以及抑制胱天蛋白酶3的抗癌剂：xIAP结合 通过上述方法。 根据本发明，可以开发聚焦于xIAP和caspase3的靶向抗癌剂，凋亡相关蛋白，因此可以应用于定制药物和联合治疗。 此外，通过本发明筛选的糖苷抗生素chromomycin具有抑制参与凋亡的xIAP和半胱天冬酶3之间的结合的活性，因此可以用作骨髓性白血病和实体瘤的治疗剂。

    EMBOSSING CHUCK ENABLING WAFER TO BE EASILY DETACHED THEREFROM
    58.
    发明申请
    EMBOSSING CHUCK ENABLING WAFER TO BE EASILY DETACHED THEREFROM 审中-公开
    破碎机可以轻松拆卸

    公开(公告)号：US20070109714A1

    公开(公告)日：2007-05-17

    申请号：US11559655

    申请日：2006-11-14

    申请人： Seng-hyun CHUNG

    发明人： Seng-hyun CHUNG

    IPC分类号： H01T23/00

    CPC分类号： H01L21/6833 ,  H02N13/00

    摘要： An embossing chuck has an embossing part protruding, in a uniform height, from an upper surface of a body on which the wafer is put on. When viewed from the above, an area of the embossing part is 5˜30% for a total area of the body. According to the chuck, since most of the charges existing in the chuck are concentrated at the embossing part and escape through the embossing part, when the embossing part is provided, the electrostatic force attracting the wafer becomes weak, as compared to a case where the embossing part is not provided to the chuck. Therefore, it is possible to easily detach the wafer from the chuck.

    摘要翻译： 压花卡盘具有从其上放置晶片的主体的上表面以均匀的高度突出的压花部。 当从上方观察时，对于身体的总面积，压花部分的面积为5〜30％。 根据卡盘，由于卡盘中存在的大部分电荷集中在压花部分并通过压花部分逸出，所以当设置压印部分时，与晶片的情况相比，吸引晶片的静电力变弱 不向卡盘提供压花部分。 因此，可以容易地将晶片从卡盘上分离。

    Contents search system for providing reliable contents through network and method thereof
    59.
    发明申请
    Contents search system for providing reliable contents through network and method thereof 有权
    通过网络提供可靠内容的内容搜索系统及其方法

    公开(公告)号：US20070078838A1

    公开(公告)日：2007-04-05

    申请号：US11603576

    申请日：2006-11-22

    申请人： Hyun Chung

    发明人： Hyun Chung

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30864 ,  Y10S707/99931 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934

    摘要： Disclosed is a contents search system and method for providing reliable search results. In the method, search results are identified by searching contents for information that pertains to a query word inputted from a user via the network are searched. Then, a degree of reliability of the search results is determined in consideration of at least one evaluation variable, and the search results are provided to the user according to the determined degree of reliability. With this configuration, reliable search results can be identified among contents posted on a network.

    摘要翻译： 公开了一种用于提供可靠搜索结果的内容搜索系统和方法。 在该方法中，搜索结果通过搜索内容来识别通过网络从用户输入的查询词的信息。 然后，考虑到至少一个评价变量来确定搜索结果的可靠性程度，并且根据确定的可靠度向用户提供搜索结果。 利用该配置，可以在网络上发布的内容之间识别可靠的搜索结果。

    Search system and method using a plurality of searching criterion
    60.
    发明申请
    Search system and method using a plurality of searching criterion 有权
    使用多个搜索标准的搜索系统和方法

    公开(公告)号：US20070073667A1

    公开(公告)日：2007-03-29

    申请号：US11606747

    申请日：2006-11-30

    申请人： Hyun Chung

    发明人： Hyun Chung

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30864

    摘要： Disclosed is a search system using a plurality of search references, and a search method thereof. When a search word is provided by a user terminal through a network, search targets to be searched are established based on the search word. The search process is performed by applying different search references to the respective search targets, and search results are provided to the search targets. According to the present invention, more reliable information is provided.

    摘要翻译： 公开了一种使用多个搜索引用的搜索系统及其搜索方法。 当用户终端通过网络提供搜索词时，将根据搜索词建立搜索目标。 通过对各个搜索目标应用不同的搜索引用来执行搜索过程，并且将搜索结果提供给搜索目标。 根据本发明，提供更可靠的信息。