公开(公告)号：US20170088621A1

公开(公告)日：2017-03-30

申请号：US15276231

申请日：2016-09-26

Applicant: LegoChem Biosciences, Inc.

Inventor： Yong Zu Kim ,  Yun Hee Park ,  Hyo Jung Choi ,  Ji Eun Jung ,  Jeong Hee Ryu ,  Ho Young Song ,  Jeiwook Chae ,  Chul-Woong Chung

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6889

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-epidermal growth factor receptor (“EGFR”) antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the drug; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.