公开(公告)号：US07826860B2

公开(公告)日：2010-11-02

申请号：US12231563

申请日：2008-09-04

申请人： Patrick Worfolk ,  Xiaoming Zhou

发明人： Patrick Worfolk ,  Xiaoming Zhou

IPC分类号： H04B7/00 ,  H04B15/00

CPC分类号： H04W56/002

摘要： A device and method for of synchronizing a MAC superframe of a wireless device is disclosed. The wireless device can be located within a chain of a plurality of other wireless devices. The method includes receiving beacons from at least one other device during a superframe of the wireless device, determining a superframe offset for each of the other wireless devices based on timing of the received beacons, determining a corrective delay based on the superframe offsets, inserting the corrective delay within a current superframe of the wireless device, and inserting a predictive delay within the current superframe, the predictive delay being determined by an estimate of a difference between a frequency a clock of the wireless device and a frequency of a slowest clock of the other wireless devices within the chain.

摘要翻译： 公开了一种用于同步无线设备的MAC超帧的设备和方法。 无线设备可以位于多个其他无线设备的链路内。 该方法包括在无线设备的超帧期间从至少一个其他设备接收信标，基于接收到的信标的定时确定每个其他无线设备的超帧偏移，基于超帧偏移确定校正延迟，插入 在无线设备的当前超帧内的校正延迟，以及在当前超帧内插入预测延迟，所述预测延迟由所述无线设备的时钟频率与所述无线设备的最慢时钟的频率之间的差的估计来确定 链中的其他无线设备。

公开(公告)号：US20090176838A1

公开(公告)日：2009-07-09

申请号：US12223392

申请日：2007-01-15

申请人： Xiaoming Zhou

发明人： Xiaoming Zhou

IPC分类号： A61K31/4439 ,  G01N33/566 ,  A61K31/4184 ,  A61K31/4166 ,  C07D401/06 ,  C07D235/02 ,  C07D233/02 ,  A61P25/06 ,  A61P25/18

CPC分类号： C07D233/34 ,  C07D235/02 ,  C07D235/26 ,  C07D401/06

摘要： The invention relates to cyclourea compounds of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

摘要翻译： 本发明涉及式I的环脲化合物：或其药学上可接受的盐或溶剂合物，其中R1-R3和Z定义如说明书所述。 本发明还涉及式I化合物用于治疗，预防或改善对阻塞钙通道，特别是N型钙通道有响应的病症的用途。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US20070142360A1

公开(公告)日：2007-06-21

申请号：US11601792

申请日：2006-11-16

申请人： Qun Sun ,  Xiaoming Zhou

发明人： Qun Sun ,  Xiaoming Zhou

IPC分类号： A61K31/55 ,  A61K31/497 ,  A61K31/496 ,  A61K31/506 ,  A61K31/501

CPC分类号： C07D401/04 ,  C07D403/04 ,  C07D417/04

摘要： A compound of formula: wherein Ar, Ar1, Ar2, R3-R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.

摘要翻译： 下式化合物：其中Ar，Ar 1，Ar 2，R 3，R 6，R 6， 本文公开了本文公开的1,3'，m和t或其药学上可接受的盐（“羟基亚氨基哌嗪化合物”）; 包含有效量的羟基亚氨基哌嗪化合物的组合物; 以及用于治疗或预防动物中的疼痛和其它病症的方法，包括向有需要的动物施用有效量的羟基亚氨基哌嗪化合物。

公开(公告)号：US20060235055A1

公开(公告)日：2006-10-19

申请号：US11317832

申请日：2005-12-22

申请人： Donald Kyle ,  Qun Sun ,  Xiaoming Zhou

发明人： Donald Kyle ,  Qun Sun ,  Xiaoming Zhou

IPC分类号： A61K31/4439 ,  C07D403/02

CPC分类号： C07D401/04 ,  C07D401/12

摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.

摘要翻译： 本发明提供式（I）化合物：其中R 1，Q，A和R 2 2在本文中公开）或其药学上可接受的盐（“吡啶” - 炔基化合物“）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能 亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。