公开(公告)号：US06548539B1

公开(公告)日：2003-04-15

申请号：US10090866

申请日：2002-03-05

申请人： Stanislaw Pikul ,  Daniel R. Soppet ,  Paul E. Young

发明人： Stanislaw Pikul ,  Daniel R. Soppet ,  Paul E. Young

IPC分类号： A61K3134

CPC分类号： C07C323/42 ,  C07C323/40 ,  C07C323/41 ,  C07C323/44 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/22

摘要： Compounds of the general structure according to Formula (I) wherein R1 is selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl; R2 is selected from alkyl, alkenyl, alkyny, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; R3 is selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; W is selected from Ch2, O and S; n is 0 to about 3: X is selected from S or O; Y, if present, is selected from a bond, aryl, NH, NR, O or S, where R3 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; and Z, if present, can represent a bond or is selected from lower alkyl, O or S are disclosed. Also disclosed are uses of such compounds for treating a variety of disease conditions, including cancer.

摘要翻译： 其中R 1选自烷基，烯基，炔基，杂烷基，卤代烷基，芳基，芳烷基，杂芳基，杂芳基烷基，环烷基和杂环烷基中的根据式（I）的通式结构的化合物; R 2选自烷基，烯基，炔基，杂烷基，卤代烷基，芳基烷基，杂芳基烷基，环烷基烷基和杂环烷基烷基; R 3选自芳基，杂芳基，环烷基和杂环烷基; W选自Ch2，O和S; n为0至约3：X选自S或O; Y如果存在，选自键，芳基，NH，NR，O或S，其中R 3选自氢，烷基，烯基，炔基，杂烷基，卤代烷基，芳基烷基，杂芳基烷基，环烷基烷基和杂环烷基烷基; 和Z如果存在，可以表示键或选自低级烷基，O或S。 还公开了这些化合物用于治疗各种疾病状况（包括癌症）的用途。

公开(公告)号：US06413933B1

公开(公告)日：2002-07-02

申请号：US09357905

申请日：1999-07-21

申请人： Daniel R. Soppet ,  Haodong Li

发明人： Daniel R. Soppet ,  Haodong Li

IPC分类号： A61K3818

CPC分类号： C07K14/495 ,  A61K48/00 ,  C12N2799/026

摘要： The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

摘要翻译： 本发明公开了生长因子HTTER36多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和包括刺激细胞生长和分化，骨形成和伤口愈合的多肽的治疗用途产生此类多肽的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性肿瘤的治疗剂的用途，并且防止在肝脏和肺中形成细胞外基质分子。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。