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    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
    51.
    发明申请
    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them 有权
    双环杂环，含有这些化合物的药物组合物，它们的用途和制备方法

    公开(公告)号：US20050014772A1

    公开(公告)日：2005-01-20

    申请号：US10860453

    申请日：2004-06-03

    申请人： Frank Himmelsbach ,  Rainer Soyka ,  Birgit Jung

    发明人： Frank Himmelsbach ,  Rainer Soyka ,  Birgit Jung

    IPC分类号： A61K31/422 ,  A61K31/4709 ,  A61K31/517 ,  A61P35/00 ,  C07D20060101 ,  C07D239/94 ,  C07D413/12 ,  C07

    CPC分类号： C07D413/12 ,  C07D239/94

    摘要： The present invention relates to bicyclic heterocycles of general formula wherein Ra, Rb, Rc, Rd, X and n are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibiting effect on the signal transduction mediated by tyrosine kinases, their use in treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract and the preparation thereof.

    摘要翻译： 本发明涉及通式的双环杂环，其中R a，R b，R c，R d，X和n如权利要求1中所定义，互变异构体，立体异构体，其混合物 特别是其具有有价值的药理学特性的无机或有机酸的生理上可接受的盐，特别是对由酪氨酸激酶介导的信号转导的抑制作用，它们在治疗疾病尤其是肿瘤性疾病中的用途以及良性前列腺素 增生（BPH），肺和呼吸道疾病及其制备。

    Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same
    53.
    发明授权
    Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same 有权
    双环杂环，含有所述化合物的药物，其用途及其制备方法

    公开(公告)号：US08399461B2

    公开(公告)日：2013-03-19

    申请号：US12513731

    申请日：2007-11-03

    申请人： Frank Himmelsbach ,  Birgit Jung

    发明人： Frank Himmelsbach ,  Birgit Jung

    IPC分类号： A61K31/517 ,  A61K31/5377 ,  A61K31/497 ,  C07D239/94 ,  C07D413/12 ,  C07D403/12

    CPC分类号： C07D239/94

    摘要： The present invention relates to bicyclic heterocycles of general formula the tautomers, the stereoisomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and the preparation thereof.

    摘要翻译： 本发明涉及通式为其互变异构体，立体异构体，混合物和盐的双环杂环，特别是其与具有有价值药理学性质的无机或有机酸的生理上可接受的盐，特别是对由酪氨酸介导的信号转导的抑制作用 激酶，其用于治疗疾病，特别是肿瘤疾病，以及良性前列腺增生（BPH），肺和呼吸道疾病的用途及其制备。

    Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same
    56.
    发明申请
    Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same 审中-公开
    双环杂环，含有所述化合物的药物，其用途及其制备方法

    公开(公告)号：US20070135463A1

    公开(公告)日：2007-06-14

    申请号：US11567323

    申请日：2006-12-06

    申请人： Frank Himmelsbach ,  Marco Santagostino ,  Birgit Jung ,  Rainer Soyka

    发明人： Frank Himmelsbach ,  Marco Santagostino ,  Birgit Jung ,  Rainer Soyka

    IPC分类号： A61K31/517 ,  C07D403/02 ,  C07D239/94

    CPC分类号： C07D401/12 ,  C07D239/94

    摘要： The present invention relates to bicyclic heterocycles of general formula their tautomers, their stereoisomers, their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids, which have valuable pharmacological properties, in particular an inhibitory action on the signal transduction mediated by tyrosine kinases, their use for the treatment of illnesses, in particular of tumoral diseases and of benign prostatic hyperplasia (BPH), of diseases of the lung and of the airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式的双环杂环，其互变异构体，它们的立体异构体，它们的混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐，其具有有价值的药理学性质，特别是对信号转导介导的抑制作用 酪氨酸激酶，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生（BPH））的用途，用于肺和气道疾病及其制备。