公开(公告)号：US12110263B2

公开(公告)日：2024-10-08

申请号：US17740260

申请日：2022-05-09

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, Jr. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/00 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02

CPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/001 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02 ,  C07C2601/08

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US20240025858A1

公开(公告)日：2024-01-25

申请号：US18257373

申请日：2021-12-15

申请人： GW Research Limited

发明人： Alan James SILCOCK ,  Antoine MILLET ,  Karen Ka-Yen TSE ,  Paul Stuart HINCHLIFFE ,  Andrew SHARPE ,  Iain David SIMPSON ,  Joanne PEACH ,  Stefano LEVANTO

IPC分类号： C07D231/12 ,  C07C39/23 ,  C07D249/06 ,  C07D239/34 ,  C07D213/65 ,  C07D213/74 ,  C07D213/16 ,  C07D213/14 ,  C07D405/04 ,  C07D263/32 ,  C07D249/08 ,  C07D261/08 ,  C07D233/64 ,  C07D271/10 ,  C07D213/64 ,  C07D405/06 ,  C07C215/50 ,  C07C213/08 ,  C07C43/23 ,  C07C41/30 ,  C07D271/06 ,  A61P25/08

CPC分类号： C07D231/12 ,  C07C39/23 ,  C07D249/06 ,  C07D239/34 ,  C07D213/65 ,  C07D213/74 ,  C07D213/16 ,  C07D213/14 ,  C07D405/04 ,  C07D263/32 ,  C07D249/08 ,  C07D261/08 ,  C07D233/64 ,  C07D271/10 ,  C07D213/64 ,  C07D405/06 ,  C07C215/50 ,  C07C213/08 ,  C07C43/23 ,  C07C41/30 ,  C07D271/06 ,  A61P25/08

摘要： The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of novel cannabidiol compounds.

公开(公告)号：US20230286907A1

公开(公告)日：2023-09-14

申请号：US18065208

申请日：2022-12-13

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Nadia M. AHMAD ,  Corey ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Iuliana Luci ASGIAN ,  Joanne Louise CAMP ,  Lev Tyler Dewey FANNING ,  Sara Sabina HADIDA RUAH ,  Dennis HURLEY ,  Yvonne SCHMIDT ,  David SHAW ,  Urvi PATEL ,  Stephen Andrew THOMSON ,  Lidio Marx CARVALHO MEIRELES

IPC分类号： C07C235/64 ,  A61K31/165 ,  C07D307/86 ,  C07C237/42 ,  C07D239/42 ,  C07D213/69 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D239/34 ,  C07D307/79 ,  C07D317/46 ,  C07D405/12

CPC分类号： C07C235/64 ,  A61K31/165 ,  C07D307/86 ,  C07C237/42 ,  C07D239/42 ,  C07D213/69 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D239/34 ,  C07D307/79 ,  C07D317/46 ,  C07D405/12 ,  C07B2200/05 ,  C07C2601/02

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20230202941A1

公开(公告)日：2023-06-29

申请号：US18168473

申请日：2023-02-13

申请人： Lincoln University

发明人： Andriy Podolyan ,  David Rennison ,  Gregory Cook ,  Hong Jie Di ,  Keith Craig Cameron ,  Margaret Anne Brimble ,  Scott Ferguson ,  Robert Starr Ronimus ,  Vincenzo Carbone

IPC分类号： C05G3/90 ,  B09C1/08 ,  C02F1/68 ,  C05C3/00 ,  C05C9/00 ,  C07D237/14 ,  C07D239/34 ,  C07D241/18

CPC分类号： C05G3/90 ,  B09C1/08 ,  C02F1/68 ,  C05C3/00 ,  C05C9/00 ,  C07D237/14 ,  C07D239/34 ,  C07D241/18 ,  C02F2103/20

摘要： Nitrification inhibitors and uses of same to prevent nitrate leaching or nitrous oxide emissions as well as increase pasture or crop production. The nitrification inhibitors and formulations including same may be used for direct or indirect application to soil or pasture.

公开(公告)号：US20230180756A1

公开(公告)日：2023-06-15

申请号：US17924956

申请日：2021-05-10

申请人： Bayer Aktiengesellschaft

发明人： Julie GEIST ,  Cyril MONTAGNE ,  Lionel NICOLAS ,  Valerie TOQUIN ,  Mathieu GOURGUES ,  Vincent THOMAS ,  Mazen ES-SAYED (DECEASED)

IPC分类号： A01N43/707 ,  A01N43/54 ,  C07D239/34 ,  C07D253/07 ,  A01P3/00 ,  C07D403/12 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  A01N43/78

CPC分类号： A01N43/707 ,  A01N43/54 ,  C07D239/34 ,  C07D253/07 ,  A01P3/00 ,  C07D403/12 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  A01N43/78

摘要： The present disclosure relates to triazine and pyrimidine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

公开(公告)号：US20230174460A1

公开(公告)日：2023-06-08

申请号：US17920588

申请日：2021-04-21

申请人： President and Fellowes of Harvard College

发明人： Emily Balskus ,  Chi Le

IPC分类号： C07C229/42 ,  C07D261/04 ,  C07D239/34 ,  C07D241/18 ,  C07D239/42 ,  C07D237/14 ,  C07D231/56 ,  C07D213/65 ,  C07C229/36 ,  C07D213/64 ,  C07C291/04

CPC分类号： C07C229/42 ,  C07D261/04 ,  C07D239/34 ,  C07D241/18 ,  C07D239/42 ,  C07D237/14 ,  C07D231/56 ,  C07D213/65 ,  C07C229/36 ,  C07D213/64 ,  C07C291/04

摘要： The present disclosure provides compounds of formula (I), (II), and (Ia):




Methods of preparing these molecules and their use for treatment of Parkinson's Disease are described.

公开(公告)号：US20230167073A1

公开(公告)日：2023-06-01

申请号：US17919186

申请日：2021-04-15

申请人： Teijin Pharma Limited

发明人： Sakae SUGIYAMA ,  Takuya YOKOSAKA ,  Kunio MINAMIZONO ,  Asahi KAWANA ,  Toshiyuki KANEKO ,  Akinobu MARUYAMA ,  Kosuke SASAKI ,  Shinnosuke HOSODA ,  Masaki KOSHIMIZU ,  Susumu TAKEUCHI ,  Kenta KATO ,  Nagasree CHAKKA ,  Brett M. JOHNSON ,  Ryan D. WHITE ,  Wei ZHAO

IPC分类号： C07D239/42 ,  C07D239/48 ,  C07D491/107 ,  C07D487/12 ,  C07D239/47 ,  C07D401/04 ,  C07D239/34 ,  C07D487/04 ,  C07D417/04 ,  C07D413/04 ,  C07D409/04 ,  C07D239/52 ,  C07D237/22 ,  C07D237/14 ,  C07D417/12 ,  C07D409/12 ,  C07D405/12 ,  C07D401/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/14 ,  C07D231/20 ,  C07D213/30 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D471/04 ,  C07D417/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/08 ,  C07D491/052

CPC分类号： C07D239/42 ,  C07D239/48 ,  C07D491/107 ,  C07D487/12 ,  C07D239/47 ,  C07D401/04 ,  C07D239/34 ,  C07D487/04 ,  C07D417/04 ,  C07D413/04 ,  C07D409/04 ,  C07D239/52 ,  C07D237/22 ,  C07D237/14 ,  C07D417/12 ,  C07D409/12 ,  C07D405/12 ,  C07D401/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/14 ,  C07D231/20 ,  C07D213/30 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D471/04 ,  C07D417/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/08 ,  C07D491/052

摘要： A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar1, Ar2, X1-X3, R1, R3, R7, R8, L1, and L2 are as defined in the specifications.)

公开(公告)号：US20230142714A1

公开(公告)日：2023-05-11

申请号：US17740260

申请日：2022-05-09

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, JR. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  C07D401/12 ,  A61K31/655 ,  A61K31/165 ,  C07C245/08 ,  C07C323/42 ,  C07C247/18 ,  C07D261/12 ,  C07C237/42 ,  C07D213/82 ,  A61K31/513 ,  C07D239/34 ,  C07D239/36 ,  A61P31/04 ,  C07F5/02 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4409 ,  C07D413/12 ,  C07C323/40 ,  A61K31/4406 ,  A61K31/505 ,  C07C233/78 ,  C07C235/50 ,  A61K31/44 ,  C07D257/04 ,  A61K45/06 ,  C07D239/38 ,  C07C317/28 ,  A61K31/42 ,  C07C381/00 ,  C07D213/81 ,  A61K31/41 ,  C07D213/65 ,  C07C247/16 ,  C07D213/70 ,  C07B59/00 ,  A61K31/167 ,  C07C235/10 ,  C07D213/68 ,  A61P25/00

CPC分类号： C07C233/62 ,  C07D401/12 ,  A61K31/655 ,  A61K31/165 ,  C07C245/08 ,  C07C323/42 ,  C07C247/18 ,  C07D261/12 ,  C07C237/42 ,  C07D213/82 ,  A61K31/513 ,  C07D239/34 ,  C07D239/36 ,  A61P31/04 ,  C07F5/02 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4409 ,  C07D413/12 ,  C07C323/40 ,  A61K31/4406 ,  A61K31/505 ,  C07C233/78 ,  C07C235/50 ,  A61K31/44 ,  C07D257/04 ,  A61K45/06 ,  C07D239/38 ,  C07C317/28 ,  A61K31/42 ,  C07C381/00 ,  C07D213/81 ,  A61K31/41 ,  C07D213/65 ,  C07C247/16 ,  C07D213/70 ,  C07B59/001 ,  A61K31/167 ,  C07C235/10 ,  C07D213/68 ,  A61P25/00 ,  C07C2601/08

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US20180353508A1

公开(公告)日：2018-12-13

申请号：US15869635

申请日：2018-01-12

申请人： Celgene CAR LLC

发明人： Kwangho Lee ,  Deqiang Niu ,  Russell C. Petter ,  Matthew Frank Baevsky ,  Juswinder Singh

IPC分类号： A61K31/506 ,  A61K31/551 ,  A61K31/541 ,  A61K31/5377 ,  C07D403/14 ,  C07D239/47 ,  C07D239/42 ,  C07D239/34 ,  C07D239/48

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D239/34 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D403/14

摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

公开(公告)号：US20180273478A1

公开(公告)日：2018-09-27

申请号：US15547227

申请日：2016-01-29

申请人： THE UNIVERSITY OF SYDNEY

发明人： Lenka Munoz ,  Fadi Maged Shokry Gurgis ,  Mia Akerfeldt ,  Michael Kassiou

IPC分类号： C07D213/61 ,  C07D213/56 ,  C07D239/34 ,  C07C233/11 ,  C07D239/26 ,  C07C233/29 ,  C07D215/14 ,  A61P35/00

CPC分类号： C07D213/61 ,  A61P35/00 ,  C07C233/11 ,  C07C233/29 ,  C07C237/20 ,  C07D213/56 ,  C07D215/14 ,  C07D239/26 ,  C07D239/34

摘要： The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).