公开(公告)号：US20050189185A1

公开(公告)日：2005-09-01

申请号：US10410125

申请日：2003-04-08

申请人： Paul Turner

发明人： Paul Turner

IPC分类号： B62K21/04 ,  B62K25/08 ,  F16F9/348

CPC分类号： B62K21/02 ,  B62K21/04 ,  B62K25/02 ,  B62K25/08 ,  B62K2025/025 ,  B62K2025/048 ,  B62K2206/00 ,  F16F9/462 ,  F16F9/54 ,  Y10T74/2078

摘要： A suspension travel adjustment mechanism comprises a housing containing a fluid, and a shaft extending through the housing. A piston is coupled to the shaft to define an upper chamber and a lower chamber within the housing. A fluid passageway extends between the upper chamber and the lower chamber. A mechanism is used for selectively opening and closing the fluid passageway from outside of the housing permit the fluid to flow between the upper chamber and the lower chamber when the fluid passageway is opened.

摘要翻译： 悬架行程调节机构包括容纳流体的壳体和延伸穿过壳体的轴。 活塞联接到轴以在壳体内限定上室和下室。 流体通道在上室和下室之间延伸。 用于从壳体外部选择性地打开和关闭流体通道的机构允许当流体通道打开时流体在上腔室和下腔室之间流动。

公开(公告)号：US06300330B1

公开(公告)日：2001-10-09

申请号：US09297768

申请日：1999-05-07

申请人： Andrew Stocker ,  John Preston ,  John Wall Rayner ,  Michael James Smithers ,  Paul Turner

发明人： Andrew Stocker ,  John Preston ,  John Wall Rayner ,  Michael James Smithers ,  Paul Turner

IPC分类号： A61K31496

CPC分类号： C07D213/73 ,  A61K31/44 ,  A61K31/505 ,  C07D213/56 ,  C07D213/61 ,  C07D213/84 ,  C07D213/89 ,  C07D237/08 ,  C07D239/26

摘要： The invention relates to heterocyclic derivatives of the formula (I): A—B—X1—T1(R2)—L1—T2(R3)—X2—Q or pharmaceutically acceptable salts thereof, which possess antithrombotic and anticoagulant properties due to their inhibition of Factor Xa and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

摘要翻译： 本发明涉及式（I）的杂环衍生物：AB-X1-T1（R2）-L1-T2（R3）-X2-Q或其药学上可接受的盐，由于它们抑制因子而具有抗血栓形成和抗凝血性质 因此，可用于治疗人或动物的方法。 本发明还涉及制备杂环衍生物的方法，含有它们的药物组合物及其在制备用于产生抗血栓形成或抗凝血作用的药物中的用途。