公开(公告)号：US20130109053A1

公开(公告)日：2013-05-02

申请号：US13661342

申请日：2012-10-26

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Lynn MACDONALD ,  Andrew J. MURPHY ,  John MCWHIRTER ,  Naxin TU ,  Vera VORONINA ,  Cagan GURER ,  Karolina MEAGHER ,  Sean STEVENS

IPC: A01K67/027 ,  C12P21/00 ,  A01K67/02

CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0387 ,  C07K14/7051 ,  C07K2319/00 ,  C12N15/8509 ,  C12N2800/204 ,  C12N2800/30

Abstract: The invention provides a genetically modified non-human animal that comprises in its genome unrearranged T cell receptor variable gene loci, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified non-human animal and methods of making the same. Various methods of using the genetically modified non-human animal are also provided.

Abstract translation: 本发明提供了一种遗传修饰的非人动物，其在其基因组中包含未经修复的T细胞受体可变基因基因座，以及胚胎，细胞和包含该基因的组织。 还提供了用于制备所述转基因非人动物的构建体及其制备方法。 还提供了使用转基因非人动物的各种方法。