公开(公告)号：US20240122164A1

公开(公告)日：2024-04-18

申请号：US18524212

申请日：2023-11-30

Applicant: The Curators of the University of Missouri

Inventor： Randall S. Prather ,  Kevin D. Wells ,  Kristin M. Whitworth

IPC: A01K67/0276 ,  A01K67/02 ,  C07K14/705 ,  C12N15/85 ,  C12N15/877

CPC classification number: A01K67/0276 ,  A01K67/02 ,  C07K14/70596 ,  C12N15/8509 ,  C12N15/8778 ,  A01K2217/075 ,  A01K2227/108 ,  A01K2267/02 ,  C12N2770/10011

Abstract: Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The animals and offspring have chromosomal modifications of a CD163 gene. The invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.

公开(公告)号：US20230270084A1

公开(公告)日：2023-08-31

申请号：US18176408

申请日：2023-02-28

Applicant: Devin George Fausett ,  Krista Fisher Fausett

Inventor： Devin George Fausett ,  Krista Fisher Fausett

IPC: A01K67/02 ,  G16B20/00 ,  G06T11/00 ,  G06F16/532

CPC classification number: A01K67/02 ,  G06F16/532 ,  G06T11/00 ,  G16B20/00 ,  A01K2227/10

Abstract: The present invention is a system and method for using DNA markers and advances in genetic phenotyping information to obtain canine offspring having a desired phenotype, wherein the genetic information of a canine sire or dam, the known parent, is used in combination with the desired phenotype of the offspring to thereby determine the necessary DNA markers of the unknown canine parent, generating a visual illustration of the unknown canine parent, and then searching through a database of potential sires and dams to identify a dam or sire that most closely resembles the predicted unknown canine parent.

公开(公告)号：US20230242984A1

公开(公告)日：2023-08-03

申请号：US18004788

申请日：2021-07-07

Applicant: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION

Inventor： Michael RON ,  Andrey SHIRAK ,  Eyal SEROUSSI ,  Hanna ROSENFELD ,  Iris MEIRI ASHKENAZI

IPC: C12Q1/6879 ,  A01K67/02 ,  A61K31/568 ,  A01K61/10

CPC classification number: C12Q1/6879 ,  A01K67/02 ,  A61K31/568 ,  A01K61/10 ,  A01K2227/40 ,  A01K2207/20 ,  C12Q2600/156

Abstract: The invention relates to a sex determination (SD) marker of a male Mugilidae fish comprising a nucleic acid sequence corresponding to a sequence of a Follicle-stimulating hormone receptor (FSHR) gene of said fish and including at least one male (Y) specific nucleotide difference when compared to a corresponding sequence on a FSHR gene of a female Mugilidae fish. The invention further concerns uses of this sex determination marker in methods of early sex determination in a Mugilidae fish, methods of sex-reversal of a Mugilidae fish prior to appearance of a sex phenotype, and methods for producing a mono-sex population of Mugilidae fishes.

公开(公告)号：US11690361B2

公开(公告)日：2023-07-04

申请号：US16445832

申请日：2019-06-19

Applicant: GENUS PLC

Inventor： Katrina Dattilo ,  Yalda Zare ,  Gabriela Marquez Betz ,  Kaleena Stephan ,  Ryan Starkenburg ,  Cristian Vergara

IPC: A01K67/02 ,  G16B20/40 ,  G16B20/20 ,  G16H50/30 ,  G16B20/00 ,  A61D19/04

CPC classification number: A01K67/02 ,  A61D19/04 ,  G16B20/00 ,  G16B20/20 ,  G16B20/40 ,  G16H50/30 ,  A01K2227/101

Abstract: Applicants have identified that three critical phenotypic/genetic measures are highly correlated with transition period health and may be used in selection and breeding protocols and/or in combination with traditional breeding and marker assisted selection methods to improve predictability of transition period health. According to the invention genetic evaluations for mastitis, ketosis, and metritis have been found to be highly predictive of overall transition health. The genetic evaluations are produced by directly measuring thousands of clinical cases of mastitis, ketosis, and metritis in ancestors of a particular animal and using this data in selection. Applicant's selection criteria and quickly impact a breeders population by reducing transition cow disease incidence in the initial population and in progeny.

公开(公告)号：US20230148569A1

公开(公告)日：2023-05-18

申请号：US17427449

申请日：2020-09-17

Applicant: GEMPHARMATECH CO., LTD.

Inventor： Cunxiang JU ,  Jing ZHAO ,  Jingjing WANG ,  Zhong CHEN

IPC: A01K29/00 ,  A01K67/02

CPC classification number: A01K29/005 ,  A01K67/02 ,  A01K2267/03 ,  A01K2227/105

Abstract: A mouse model may be used in evaluation of the change in intelligence level. The mouse model may be a mouse model with high intelligence level. The mouse chromosome of the mouse model with high intelligence level at least includes all or a portion of chromosome 1 originated from wild-type mouse. The evaluation includes performing a test which may be an open field test, sucrose preference test, water maze test, space exploration Y maze test, active avoidance Y maze test, and/or fatigue rotarod test.

公开(公告)号：US20230133281A1

公开(公告)日：2023-05-04

申请号：US16768577

申请日：2018-12-03

Applicant: CHROMOXYION PTY LTD

Inventor： Sharon Catherine DE WET

IPC: A01K67/02 ,  C07K16/28

Abstract: A method comprising the steps of: 1. optionally subjecting spermatozoa to a treatment step; 2. subjecting the spermatozoa of step 1 to a sex selection step so as to select for either female or male spermatozoa of interest; 3. carrying out a fertilisation step using the spermatazoa of interest of step 2 to produce at least one oocyte, blastocyst, ovum, embryonic cell or embryo; 4. selectively lysing the at least one oocyte, blastocyst, ovum, embryonic cell or embryo of step 3 in the presence of spermatozoa so as to selectively release cellular material from the at least one lysed oocyte, blastocyst, ovum, embryonic cell or embryo; and 5. using the released cellular material in at least one downstream application.

公开(公告)号：US20220389506A1

公开(公告)日：2022-12-08

申请号：US17360692

申请日：2021-06-28

Applicant: MARS, INCORPORATED

Inventor： Alan James Martin ,  Paul Glyn Jones ,  Adrian Watson ,  Jan Rothuizen ,  Hille Fieten ,  Pieter Antonius Jozef Leegwater

IPC: C12Q1/6883 ,  G16B20/00 ,  G16B20/20 ,  G16B20/40 ,  G16B20/10 ,  A01K67/02

Abstract: The present disclosure provides methods of determining the susceptibility of a dog to liver copper accumulation, comprising detecting in a biological sample obtained from the dog the presence or absence in the genome of the dog of one or more polymorphisms, and methods of treating or breeding the dog based on such determination.

公开(公告)号：US20220361461A1

公开(公告)日：2022-11-17

申请号：US17623382

申请日：2020-06-26

Applicant: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

Inventor： Mehdi Mirsaeidi ,  Chongxu Zhang

IPC: A01K67/02

Abstract: The disclosure relates to a sarcoidosis animal model and methods of inducing sarcoidosis in an animal. The disclosure also relates to methods of producing an in vitro granuloma, and methods of using the sarcoidosis animal model. Disclosed herein are animals comprising one or more granulomas, wherein the one or more granulomas comprise Mycobacterium abscessus cell wall microparticles.

公开(公告)号：US20220304222A1

公开(公告)日：2022-09-29

申请号：US17429624

申请日：2021-04-26

Applicant: Hunan Agriculture University

Inventor： Huang HUANG ,  Yin ZHANG ,  Jingyi LI ,  Ren WANG ,  Xiangsheng GONG ,  Zhiqiang FU ,  Can CHEN ,  Zhengjun YU ,  Yugang LIANG ,  Jiaolong DING ,  Xiangjie MENG ,  Dan WU ,  Yao HUANG ,  Xiaolan LIAO

IPC: A01C21/00 ,  A01K67/02 ,  A01G22/22 ,  A01B39/14

Abstract: A method for micro-ridge mixed-sowing cultivation of dryland crops includes the following steps: S1: cleaning ditches and draining away water in dryland; S2: harvesting the preceding crop, leaving the stubble, smashing the stalks of the preceding crop, and then spreading the smashed stalks on the stubble; S3: trenching the dryland to form ecological trenches; S4: flattening the standing stubble and the smashed stalks on the seedbed surface to form an underlying surface, molding seed-fertilizer-soil compounds into a ridge shape and falling the seed-fertilizer-soil compounds on the underlying surface to form ecological ridges, wherein a plurality of ecological ridges are formed between adjacent ecological trenches, an ecological depression is formed between adjacent ecological ridges, and after sowing, an irrigation is carried out once in a manner, wherein the manner includes: draining water shortly after the irrigation, without leaving a water layer in the field. The seed-fertilizer-soil compounds are obtained by thoroughly mixing soil with seeds of the dryland crops and chemical fertilizers.

公开(公告)号：US20220217954A1

公开(公告)日：2022-07-14

申请号：US17607417

申请日：2020-05-22

Applicant: ZHEJIANG UNIVERSITY

Inventor： Jinming PAN ,  Chenghao PAN ,  Yuchen HU ,  Leshang BAI ,  Hao JIN

IPC: A01K67/02 ,  H05B45/10 ,  A01K45/00 ,  H05B45/20

Abstract: A lighting experimental system and a lighting experimental method for reducing the ability of the poultry to recognize the red objects are provided, wherein wooden testing box is provided with an opening at the top thereof, a square adjustable light-emitting diode (LED) light source is disposed directly above the opening of the wooden testing box, a first black backdrop is fixedly laid on a surface of each inner wall of four sides of the wooden testing box, a horizontal trough is provided at the bottom of the wooden testing box, a feed box is disposed in the horizontal trough, and the feed box is connected to an electric push rod; two color photographic papers are fixed on an inner wall, directly above the horizontal trough, of the wooden testing box, pressure sensors are disposed between the color photographic papers and the inner wall of the wooden testing box.