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公开(公告)号:US5109023A
公开(公告)日:1992-04-28
申请号:US622505
申请日:1990-12-05
申请人: William L. Mitchell , Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , David Hartley
发明人: William L. Mitchell , Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , David Hartley
IPC分类号: C07C307/10 , C07C65/11 , C07C217/08 , C07C231/12 , C07C233/43 , C07C275/34 , C07C311/08 , C07C323/12 , C07C323/16 , C07C323/25
CPC分类号: C07C65/11 , Y10S514/819 , Y10S514/826 , Y10S514/886 , Y10S514/887 , Y10S514/913 , Y10S514/925 , Y10S514/927
摘要: The invention provides a method of treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis, utilizing the compounds of the formula ##STR1## or a physiological acceptable salt or solvate thereof, wherein Q represents a 1- or 2- naphthalenyl group.
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公开(公告)号:US4000192A
公开(公告)日:1976-12-28
申请号:US467211
申请日:1974-05-06
IPC分类号: C07C103/22
摘要: Compounds of the formula ##STR1## in which: R.sub.4 and R.sub.5 independently represent hydrogen or lower alkyl;R.sub.6 represents a group Y(CH.sub.2).sub.n, in which n is 2 or 3 andY represents a straight or branched chain alkyl group containing 5 carbon atoms optionally substituted with one more hydroxy or alkoxy groups or by aryl groups which may, in turn, contain hydroxy or alkoxy substituents; orY represents a group ZO--, in which Z represents a straight or branched alkyl group containing from 2 to 6 carbon atoms inclusive substituted by one or more alkoxy, hydroxy, or aryloxy groups; or Z represents an aryl group which may, optionally, contain one or more hydroxy or alkoxy substituents; andR.sub.7 represents a straight or branched alkyl group containing from 3 to 6 carbon atoms, inclusive, optionally substituted by an aryl or aryloxy group which aryl or aryloxy group may, in turn be substituted by hydroxy and alkoxy groupsAnd pharmaceutically acceptable salts thereof. These compounds have utility in the treatment of cardiovascular diseases.
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