公开(公告)号：US20060247317A1

公开(公告)日：2006-11-02

申请号：US11366413

申请日：2006-03-03

申请人： Ryuji Ueno

发明人： Ryuji Ueno

IPC分类号： A61K31/557

CPC分类号： A61K31/5575 ,  A61K31/557

摘要： The present invention provides a method for treating peripheral vascular diseases in a mammalian subject, which comprises administering to the patient in need thereof an effective amount of 11-deoxy-prostaglandin compound.

摘要翻译： 本发明提供了一种用于治疗哺乳动物受试者的外周血管疾病的方法，其包括向有需要的患者施用有效量的11-脱氧前列腺素化合物。

公开(公告)号：US07064148B2

公开(公告)日：2006-06-20

申请号：US10231341

申请日：2002-08-30

申请人： Ryuji Ueno ,  John Cuppoletti

发明人： Ryuji Ueno ,  John Cuppoletti

IPC分类号： A61K31/19

CPC分类号： C07C405/00 ,  A61K31/557

摘要： Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin compound to facilitate chloride ion transportation.

公开(公告)号：US20060063830A1

公开(公告)日：2006-03-23

申请号：US11216012

申请日：2005-09-01

申请人： Ryuji Ueno

发明人： Ryuji Ueno

IPC分类号： A61K31/558

CPC分类号： C07D311/94 ,  A61K31/557 ,  A61K31/558

摘要： The present invention relates to a method for the long term treatment of gastrointestinal disorders in a human subject, which comprises administering an effective amount of a halogenated prostaglandin compound and/or its tautomer to the subject. The method induces substantially no electrolyte shifting during the term of the treatment. The compound used in the present invention can improve quality of life in the human subjects with gastrointestinal disorders, are similarly effective in treating male and female human subjects, and also effective in a human subject aged even 65 years and older.

摘要翻译： 本发明涉及一种用于长期治疗人类受试者胃肠道疾病的方法，其包括给受试者施用有效量的卤化前列腺素化合物和/或其互变异构体。 该方法在治疗期间基本上不引起电解质移动。 本发明中使用的化合物可以改善具有胃肠道疾病的人类受试者的生活质量，在治疗男性和女性人类受试者中也是有效的，并且对于年龄甚至65岁及以上的人类受试者也是有效的。

公开(公告)号：US06956056B2

公开(公告)日：2005-10-18

申请号：US10147980

申请日：2002-05-20

申请人： Ryuji Ueno

发明人： Ryuji Ueno

IPC分类号： A61K31/5575 ,  A61P1/10 ,  C07C405/00

CPC分类号： A61K31/5575 ,  C07C405/00

摘要： The present invention relates to a novel method for providing a cathartic effect to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing effective amount of halogenated bioactive lipid comprising the following partial structure (I): The method is useful for relieving or preventing constipation, and also for cleansing the gastrointestinal tract.

摘要翻译： 本发明涉及一种向患者提供通气作用的新型方法，该方法包括向患者施用含有以下部分结构（I）的诱导有效量的卤代生物活性脂质：该方法是 有助于缓解或预防便秘，也可用于清洁胃肠道。

公开(公告)号：US20050070468A1

公开(公告)日：2005-03-31

申请号：US10495425

申请日：2002-11-20

申请人： Ryuji Ueno

发明人： Ryuji Ueno

IPC分类号： A61K31/436 ,  A61K31/4745 ,  A61K38/13 ,  A61P11/06 ,  A61P27/14

CPC分类号： A61K31/4745 ,  A61K31/436 ,  A61K38/13

摘要： The present invention provides, in the treatment of allergic diseases using an interleukin 2 inhibitor, particularly a macrolide compound such as FK506, a method of treating an allergic disease, which includes setting a leading period for pre-administration of an interleukin 2 inhibitor.

摘要翻译： 本发明提供了使用白细胞介素2抑制剂，特别是大环内酯类化合物如FK506治疗过敏性疾病的治疗过敏性疾病的方法，其包括设定白介素2抑制剂的给药前期。

公开(公告)号：US06864232B1

公开(公告)日：2005-03-08

申请号：US09869129

申请日：1999-12-20

申请人： Ryuji Ueno

发明人： Ryuji Ueno

IPC分类号： A61K31/436 ,  A61K38/13 ,  A61K38/00

CPC分类号： A61K38/13 ,  A61K31/436

摘要： The present invention provides an agent for treating retinopathy containing a tricyclo compound of formula (I)

摘要翻译： 本发明提供一种治疗视网膜病变的药剂，其含有式（I）的三环化合物，

公开(公告)号：US06476039B1

公开(公告)日：2002-11-05

申请号：US10133450

申请日：2002-04-29

申请人： Ryuji Ueno ,  Ichie Kato

发明人： Ryuji Ueno ,  Ichie Kato

IPC分类号： A61K31505

CPC分类号： A61K31/517 ,  A61K31/00 ,  Y10S514/912

摘要： The ophthalmic composition of this invention are used for treatment of diabetic corneal lesion and/or for treatment of deteriorated corneal esthesia, which comprises, as an active ingredient, a compound represented by the general formula (I): wherein A and B are independently lower alkylene, X, Y, and Z are independently halogen, or a pharmacologically acceptable salt thereof. In addition, the ophthalmic composition of this invention are used for treatment of non-diabetic corneal lesion, for treatment of dry eye syndrome, and/or for treatment of hypolacrimation which comprises, as an active ingredient, an aldose reductase inhibitor. The ophthalmic compositions of this invention are effective for treatment of at least one disease selected among corneal lesion, deteriorated corneal esthesia, dry eye syndrome, and hypolacrimation.

公开(公告)号：US06420422B1

公开(公告)日：2002-07-16

申请号：US08476583

申请日：1995-06-07

申请人： Ryuzo Ueno ,  Ryuji Ueno ,  Tomio Oda

发明人： Ryuzo Ueno ,  Ryuji Ueno ,  Tomio Oda

IPC分类号： A61K31455

CPC分类号： A61K31/557 ,  C07C405/00

摘要： The present invention relates to an ocular hypotensive composition and a composition for treatment of glaucoma which comprising an amount of 20-substituted-PGs or 20-substituted 15-keto-PGs effective as an ocular hypotensive agent; these compounds exhibit no or little side effect such as transient ocular hypertensive response, hyperemia of conjunctiva or of iris, dacryops, lema, closed eye and the like. The present invention relates to ocular hypotensive agents which contains 13,14-dihydro-15-keto-prostagrandins, which shows no transient ocular hypertensive response that PGs usually show.

摘要翻译： 本发明涉及一种眼部降血压药物组合物和治疗青光眼的组合物，其含有作为眼部降压药有效的20-取代的PG或20-取代的15-酮基-PG的量; 这些化合物没有或没有副作用，例如暂时性高眼压反应，结膜充血或虹膜，泪囊虫，莱马，闭眼等。本发明涉及含有13,14-二氢-15- 酮前列腺素，其不显示PG通常显示的暂时性高眼压反应。

公开(公告)号：US5773471A

公开(公告)日：1998-06-30

申请号：US613048

申请日：1996-03-08

申请人： Yoshihisa Oguchi ,  Yukihiko Mashima ,  Yoshiki Hiida ,  Tomihiko Tanino ,  Ryuji Ueno ,  Hiroyoshi Osama ,  Tohru Hirato

发明人： Yoshihisa Oguchi ,  Yukihiko Mashima ,  Yoshiki Hiida ,  Tomihiko Tanino ,  Ryuji Ueno ,  Hiroyoshi Osama ,  Tohru Hirato

IPC分类号： A61K31/5575 ,  A61K31/215 ,  A61K31/19

CPC分类号： A61K31/5575 ,  Y10S514/912

摘要： The present invention provides a method for treatment of optic nerve disorder by the administration of a prostanoic acid compound in an amount effective in treatment of optic nerve disorder to a subject in need of such treatment, by which visual acuity can be recovered.

摘要翻译： 本发明提供了一种治疗视神经障碍的方法，其通过以有效治疗视神经障碍的量将前列腺烷酸化合物施用于需要这种治疗的受试者，通过该方法能够恢复视力。

公开(公告)号：US5547968A

公开(公告)日：1996-08-20

申请号：US487637

申请日：1995-06-07

申请人： Ryuji Ueno

发明人： Ryuji Ueno

IPC分类号： A61K31/18 ,  A61K31/415 ,  A61K31/557 ,  A61K45/06 ,  A61P9/12 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  A61K31/41 ,  A61K31/19 ,  A61K31/215

CPC分类号： A61K31/557 ,  Y10S514/913

摘要： A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of(a) a 15-ketoprostaglandin or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and(b) a carbonate dehydratase inhibitor in an amount effective in treatment of ocular hypertension.

摘要翻译： 一种治疗眼高血压的方法，其包括向需要这种治疗的受试者眼睛施用（a）15-酮前列腺素或其药学上可接受的盐或其药学上可接受的酯的眼 - 低协同组合，和 （b）有效治疗高眼压症的碳酸酯脱水酶抑制剂。