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    Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
    7.
    发明授权
    Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor 有权
    治疗由抗肿瘤剂引起的损伤，治疗粘膜炎和治疗肿瘤的方法

    公开(公告)号：US09084815B2

    公开(公告)日：2015-07-21

    申请号：US12882794

    申请日：2010-09-15

    申请人： Ryuji Ueno

    发明人： Ryuji Ueno

    IPC分类号： A01N43/16 ,  A61K31/35 ,  A61K45/06 ,  A61K31/352 ,  A61K31/713 ,  A61K39/395

    CPC分类号： A61K31/558 ,  A61K31/352 ,  A61K31/5575 ,  A61K31/713 ,  A61K39/395 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed is a method for treating tumor in a mammalian subject, which comprises administering a combination of (a) an anti-tumor agent and (b) a fatty acid derivative represented by the formula (I): to the subject in need thereof. The application also discloses a method for treating damages, especially gastrointestinal damages including mucositis such as stomatitis induced by an anti-tumor agent, wherein the method comprises administering a fatty acid derivative of formula (I) to the subject who is receiving the anti-tumor agent.

    摘要翻译： 本发明涉及一种哺乳动物受试者的肿瘤治疗方法，其特征在于：（a）抗肿瘤剂和（b）式（I）所示的脂肪酸衍生物的组合：需要的受试者。 本申请还公开了一种治疗损伤的方法，特别是包括由抗肿瘤剂诱导的口腔炎等粘膜炎的消化道损伤，其中所述方法包括向接受抗肿瘤的受试者施用式（I）的脂肪酸衍生物 代理商

    SELECTIVE TUMOR TREATMENT
    8.
    发明申请
    SELECTIVE TUMOR TREATMENT 审中-公开
    选择性肿瘤治疗

    公开(公告)号：US20150099802A1

    公开(公告)日：2015-04-09

    申请号：US14503922

    申请日：2014-10-01

    申请人： SUCAMPO AG

    发明人： Ryuji UENO ,  Sachiko KUNO

    IPC分类号： C07D311/94 ,  C12Q1/68 ,  G01N33/573 ,  C12Q1/32

    CPC分类号： C07D311/94 ,  A61K31/558 ,  C12Q1/32 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/573 ,  G01N2333/904 ,  G01N2800/52

    摘要： A method for treating a tumor with a decreased level of the 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative, a method for suppressing the growth of a tumor cell with a decreased level of the 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which comprises contacting said tumor cell with an effective amount of a fatty acid derivative, and a method for identifying a subject who would be responsive to a fatty acid derivative, comprising, (i) obtaining a biological sample from said subject; and (ii) measuring 15-hydroxyprostaglandin dehydrogenase (15-PGDH) level are provided.

    摘要翻译： 一种用于治疗哺乳动物受试者中15-羟基 - 前列腺素脱氢酶（15-PGDH）水平降低的肿瘤的方法，其包括向有需要的受试者施用有效量的脂肪酸衍生物，抑制 包括使所述肿瘤细胞与有效量的脂肪酸衍生物接触的15-羟基 - 前列腺素脱氢酶（15-PGDH）水平降低的肿瘤细胞的生长，以及用于鉴定将是 响应于脂肪酸衍生物，包括：（i）从所述受试者获得生物样品; 和（ii）测量15-羟基前列腺素脱氢酶（15-PGDH）水平。

    Autotaxin inhibitors
    9.
    发明授权
    Autotaxin inhibitors 有权
    自体贴剂抑制剂

    公开(公告)号：US08969590B1

    公开(公告)日：2015-03-03

    申请号：US13622018

    申请日：2012-09-18

    申请人： University of Memphis Research Foundation

    发明人： Abby Louise Parrill-Baker ,  Daniel Lee Baker

    IPC分类号： C07D471/04 ,  C07D209/48 ,  C07D401/14

    CPC分类号： C07D471/04 ,  A61K31/517 ,  A61K31/558 ,  C07D209/48 ,  C07D401/14

    摘要： Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include thioureas, diphenyldiazerenes, xanthenes, and isoindoles and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

    摘要翻译： 提供表现出有效抑制自体素蛋白酶的化合物类别。 这些类别包括硫脲，二苯基二氮杂，呫吨和异吲哚，并表现出与自分泌素的反应性，以最终减小其上的反应位点的大小，以防止溶血磷脂酰胆碱转化成溶血磷脂酸。 此外，这些化合物可以并入用于人体摄取的递送形式中。 因此，这些化合物具有潜在地减少由于天然存在的自体贴剂在人体内的存在而导致某些癌症的产生的优异方式。 使用这种化合物将自分生菌素灭活至一定程度的方法也包括在本发明范围内。

    Method for modulating claudin mediated functions
    10.
    发明授权
    Method for modulating claudin mediated functions 失效
    调节克拉丁介导功能的方法

    公开(公告)号：US08569279B2

    公开(公告)日：2013-10-29

    申请号：US12853692

    申请日：2010-08-10

    申请人： Ryuji Ueno ,  Sachiko Tsukita

    发明人： Ryuji Ueno ,  Sachiko Tsukita

    IPC分类号： A01N43/00 ,  A61K31/33

    CPC分类号： A61K31/352 ,  A61K31/5575 ,  A61K31/558

    摘要： Disclosed is a method for modulating a claudin-mediated function in a mammalian subject which comprises administering to a subject in need thereof an effective amount of a specific fatty acid derivative. The application also discloses a method for treating a dermatological disease and a method for modulating an expression of a claudin in a mammalian subject using the same fatty acid derivative as above.

    摘要翻译： 公开了一种用于调节哺乳动物受试者的紧密连接蛋白介导的功能的方法，其包括向有需要的受试者施用有效量的特定脂肪酸衍生物。 本申请还公开了一种用于使用与上述相同的脂肪酸衍生物在哺乳动物受试者中治疗皮肤病的方法和调节紧密连蛋白的表达的方法。