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公开(公告)号:US20050058642A1
公开(公告)日:2005-03-17
申请号:US10898408
申请日:2004-07-23
申请人: Laurent Galibert , Wei Yan
发明人: Laurent Galibert , Wei Yan
IPC分类号: A61K39/395 , C07K14/705 , C07K16/18 , C07K16/28 , C12N5/08 , C12N15/62 , G01N33/50 , G01N33/53
CPC分类号: C07K16/2803 , C07K2319/30
摘要: The invention pertains to agonists and antagonists of LDCAM and methods of treating disease and infection by administering one or more LDCAM antagonists or agonists. This abstract is provided for the sole purpose of enabling the reader to quickly ascertain the subject matter of the technical disclosure and is not intended to be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).
摘要翻译: 本发明涉及LDCAM的激动剂和拮抗剂以及通过施用一种或多种LDCAM拮抗剂或激动剂治疗疾病和感染的方法。 提供本摘要的唯一目的是使读者能够快速确定技术公开内容的主题,并不意图用于解释或限制权利要求书的范围或含义。 37 CFR 1.72(b)。
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公开(公告)号:US06806075B1
公开(公告)日:2004-10-19
申请号:US09959392
申请日:2002-06-25
申请人: John Michael Morser , Qingyu Wu , Wei Yan
发明人: John Michael Morser , Qingyu Wu , Wei Yan
IPC分类号: C12N964
CPC分类号: C12Q1/37
摘要: The present invention relates to a corin polypeptide which contains one or more frizzled corin and possesses various activities, including, e.g., serin protease activity and a pro-ANF converting activity, LDLR, SRCR repeats, serine protease catalytic domains such as human and mouse corin. The invention further relates to methods of using such nucleic acids and polypeptides in therapeutics, diagnostics, and research. For example, the nucleic acids and polypeptides of corin can be utilized in methods to identify modulators of its activity, in animal models to mimic human disease, and to treat kidney, cardiovascular, and other conditions in which corin is involved.
摘要翻译: 本发明涉及包含一个或多个卷曲的corin并且具有各种活性的corin多肽,其包括例如丝氨酸蛋白酶活性和原-ANF转化活性,LDLR,SRCR重复序列,丝氨酸蛋白酶催化结构域如人和小鼠corin 。 本发明还涉及在治疗,诊断和研究中使用这些核酸和多肽的方法。 例如,Corin的核酸和多肽可用于鉴定其活性的调节剂,在模拟人类疾病的动物模型中,以及治疗涉及corin的肾,心血管和其他病症的方法。
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