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公开(公告)号:US06699677B1
公开(公告)日:2004-03-02
申请号:US09721908
申请日:2000-11-24
申请人: Thomas J. Schall , Brett Premack , Zhenhua Miao , Zheng Wei
发明人: Thomas J. Schall , Brett Premack , Zhenhua Miao , Zheng Wei
IPC分类号: G01N33567
CPC分类号: G01N33/6863 , C07K14/521 , C07K14/7158 , C07K2319/00 , G01N33/5088 , G01N33/531 , G01N2500/00
摘要: The invention provides methods, reagents and devices for analysis of receptor ligand interactions, determining the profile of receptor expression in cells and cell populations, and diagnostic and drug screening methods. The invention makes use of immobilized tethered ligand fusion proteins having a ligand domain, a stalk domain, and optionally an immobilization domain.
摘要翻译: 本发明提供用于分析受体配体相互作用的方法,试剂和装置,确定细胞和细胞群体中受体表达的谱,以及诊断和药物筛选方法。 本发明利用具有配体结构域,茎结构域和任选的固定结构域的固定化的束缚配体融合蛋白。