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51.发明申请KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES 失效用于治疗单纯性疾病和其他增殖性疾病的激酶抑制剂公开(公告)号：US20080261965A1
公开(公告)日：2008-10-23
申请号：US12105408
申请日：2008-04-18
IPC分类号： A61K31/5383 , A61K31/4439 , C07D413/14 , A61P35/00 , C07D498/04 , C07D401/04
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant, melanomas, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, leukemias, papillary thyroid carcinoma, non small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocyclosis, mast cell leukemia, a disease caused by c-Abl kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, or a disease caused by c-Kit kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof.
摘要翻译： 本发明的化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性，黑素瘤，成胶质细胞瘤，卵巢癌，胰腺癌，前列腺癌，肺癌，乳腺癌，肾癌，宫颈癌，转移 原发性肿瘤部位，骨髓增生性疾病，白血病，甲状腺乳头状癌，非小细胞肺癌，间皮瘤，嗜酸性粒细胞综合征，胃肠道间质瘤，结肠癌，以过度增生为特征的眼部疾病导致失明，包括各种视网膜病变，类风湿关节炎，哮喘，慢性 阻塞性肺疾病，乳腺增生症，肥大细胞白血病，由c-Abl激酶引起的疾病，其致癌形式，异常融合蛋白及其多形体，或由c-Kit激酶，其致癌形式，异常融合蛋白引起的疾病，以及 其多晶型。
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52.发明申请KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES 有权用于治疗单发性增生性疾病和其他增殖性疾病的激素抑制剂公开(公告)号：US20080090856A1
公开(公告)日：2008-04-17
申请号：US11870388
申请日：2007-10-10
申请人： Daniel Flynn , Peter Petillo , Michael Kaufman
发明人： Daniel Flynn , Peter Petillo , Michael Kaufman
IPC分类号： A61K31/505 , A61K31/44 , A61P35/00 , C07D215/00 , C07D239/02 , C07D213/00 , A61K31/47
CPC分类号： C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention is concerned with novel compounds useful in the treatment of hyperproliferative diseases and mammalian cancers, especially human cancers. The invention also pertains to methods of modulating kinase activities, pharmaceutical compositions, and methods of treating individuals, incorporating or using the compounds. The preferred compounds are active small molecules set forth in formulae Ia-Iww.
摘要翻译： 本发明涉及可用于治疗过度增殖性疾病和哺乳动物癌症，特别是人类癌症的新化合物。 本发明还涉及调节激酶活性的方法，药物组合物和治疗个体的方法，掺入或使用该化合物。 优选的化合物是式Ia-Iww中所示的活性小分子。
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公开(公告)号：US11433056B1
公开(公告)日：2022-09-06
申请号：US17735862
申请日：2022-05-03
发明人： Rodrigo Ruiz Soto , Oliver Rosen , Jama Pitman
IPC分类号： A61K31/4375 , A61K31/4745 , A61P9/12 , A61P35/00
摘要： The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220265623A1
公开(公告)日：2022-08-25
申请号：US17735784
申请日：2022-05-03
发明人： Michael D. Kaufman , Scott Bone , Corey Bloom , Fred Jordan
IPC分类号： A61K31/4375 , A61K9/16 , A61K9/20
摘要： Provided herein is an amorphous compound represented by Formula (I): and compositions thereof, which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.
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公开(公告)号：US20220265620A1
公开(公告)日：2022-08-25
申请号：US17735678
申请日：2022-05-03
发明人： Rodrigo Ruiz Soto , Oliver Rosen , Jama Pitman
IPC分类号： A61K31/4375 , A61K31/4745 , A61P35/00 , A61P9/12
摘要： The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220241256A1
公开(公告)日：2022-08-04
申请号：US17727307
申请日：2022-04-22
发明人： Rodrigo Ruiz Soto , Oliver Rosen , Jama Pitman
IPC分类号： A61K31/4375 , A61P35/00 , A61P9/12 , A61K31/4745
摘要： The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11344536B1
公开(公告)日：2022-05-31
申请号：US17583985
申请日：2022-01-25
发明人： Rodrigo Ruiz Soto , Oliver Rosen , Jama Pitman
IPC分类号： A61K31/4375 , A61K31/4745 , A61P35/00 , A61P9/12
摘要： The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220142997A1
公开(公告)日：2022-05-12
申请号：US17583977
申请日：2022-01-25
发明人： Rodrigo Ruiz Soto , Oliver Rosen , Jama Pitman
IPC分类号： A61K31/4375 , A61P35/00
摘要： The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11266635B2
公开(公告)日：2022-03-08
申请号：US17180218
申请日：2021-02-19
发明人： Rodrigo Ruiz Soto , Oliver Rosen , Jama Pitman
IPC分类号： A61K31/4375 , A61P35/00
摘要： The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210196691A1
公开(公告)日：2021-07-01
申请号：US17180218
申请日：2021-02-19
发明人： Rodrigo Ruiz Soto , Oliver Rosen , Jama Pitman
IPC分类号： A61K31/4375 , A61P35/00
摘要： The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
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