公开(公告)号：US12213967B2

公开(公告)日：2025-02-04

申请号：US18795683

申请日：2024-08-06

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Michael D. Kaufman ,  Scott Bone ,  Corey Bloom ,  Fred Jordan

IPC: A61K9/10 ,  A61K9/00 ,  A61K31/4375 ,  A61K47/38

Abstract: Provided herein are low impurity compositions comprising a compound represented which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

公开(公告)号：US20240390344A1

公开(公告)日：2024-11-28

申请号：US18795711

申请日：2024-08-06

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Michael D. Kaufman ,  Scott Bone ,  Corey Bloom ,  Fred Jordan

IPC: A61K31/4375 ,  A61K9/00 ,  A61K9/10 ,  A61K47/38

Abstract: Provided herein are low impurity compositions comprising a compound represented by Formula (I): which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

公开(公告)号：US12023325B2

公开(公告)日：2024-07-02

申请号：US18500650

申请日：2023-11-02

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Rodrigo Ruiz Soto ,  Oliver Rosen ,  Jama Pitman

IPC: A61K31/4375 ,  A61K31/4745 ,  A61P9/12 ,  A61P35/00

CPC classification number: A61K31/4375 ,  A61K31/4745 ,  A61P9/12 ,  A61P35/00

Abstract: The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240180923A1

公开(公告)日：2024-06-06

申请号：US18457825

申请日：2023-08-29

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Rodrigo Ruiz Soto ,  Frederic J. Reu ,  Matthew L. Sherman ,  Daniel L. Flynn ,  Madhumita Bogdan ,  Bryan D. Smith ,  Gada Al-Ani

IPC: A61K31/553 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/553 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.

公开(公告)号：US20240148706A1

公开(公告)日：2024-05-09

申请号：US18518110

申请日：2023-11-22

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Michael D. Kaufman ,  Scott Bone ,  Corey Bloom ,  Fred Jordan

IPC: A61K31/4375 ,  A61K9/00 ,  A61K9/10 ,  A61K47/38

CPC classification number: A61K31/4375 ,  A61K9/0053 ,  A61K9/10 ,  A61K47/38

Abstract: Provided herein are low impurity compositions comprising a compound represented by Formula (I):




which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

公开(公告)号：US20240116877A1

公开(公告)日：2024-04-11

申请号：US18073721

申请日：2022-12-02

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Yu Mi Ahn ,  Timothy Caldwell ,  Daniel L. Flynn ,  Bertrand LeBourdonnec

IPC: C07D239/94 ,  C07D237/28 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D487/08

CPC classification number: C07D239/94 ,  C07D237/28 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D487/08

Abstract: Described herein are compounds that are inhibitors of wild type and oncogenic mutant c-KIT kinase and their use in the treatment of disorders such as cancers.

公开(公告)号：US20240066012A1

公开(公告)日：2024-02-29

申请号：US18490188

申请日：2023-10-19

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Michael D. Kaufman ,  Scott Bone ,  Corey Bloom ,  Fred Jordan

IPC: A61K31/4375 ,  A61K9/00 ,  A61K9/10 ,  A61K47/38

CPC classification number: A61K31/4375 ,  A61K9/0053 ,  A61K9/10 ,  A61K47/38

Abstract: Provided herein are low impurity compositions comprising a compound represented by Formula (I):




which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

公开(公告)号：US11896585B2

公开(公告)日：2024-02-13

申请号：US18148766

申请日：2022-12-30

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Michael D. Kaufman ,  Scott Bone ,  Corey Bloom ,  Fred Jordan

IPC: A61K31/4375 ,  A61K47/38 ,  A61K9/00 ,  A61K9/10

CPC classification number: A61K31/4375 ,  A61K9/0053 ,  A61K9/10 ,  A61K47/38

Abstract: Provided herein are low impurity compositions comprising a compound represented by Formula (I):




which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

公开(公告)号：US20230390256A1

公开(公告)日：2023-12-07

申请号：US18448312

申请日：2023-08-11

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Michael D. Kaufman ,  Scott Bone ,  Corey Bloom ,  Fred Jordan

IPC: A61K31/4375 ,  A61K47/38 ,  A61K9/00 ,  A61K9/10

CPC classification number: A61K31/4375 ,  A61K47/38 ,  A61K9/0053 ,  A61K9/10

Abstract: Provided herein are low impurity compositions comprising a compound represented by Formula (I):




which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

公开(公告)号：US20230145926A1

公开(公告)日：2023-05-11

申请号：US18091743

申请日：2022-12-30

Applicant: Deciphera Pharmaceuticals, LLC

Inventor： Rodrigo Ruiz Soto ,  Oliver Rosen ,  Jama Pitman

IPC: A61K31/4375 ,  A61P35/00 ,  A61P9/12 ,  A61K31/4745

CPC classification number: A61K31/4375 ,  A61P35/00 ,  A61P9/12 ,  A61K31/4745

Abstract: The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.