摘要:
A positive pressure long-term drug delivery device particularly useful for the intravaginal or intrauterine release of a drug capable of passing through a diffusion membrane and being absorbed by the vaginal or uterine epithelium. The device includes a tubular casing having a plunger urged by a compression spring to create a continuous positive pressure on a drug in liquid form within the chamber of the casing, a supported membrane at one end of the casing through which such drug diffuses at a predetermined rate, and resilient elements at the opposite end of the casing for facilitating retention of the device throughout the term of administration of the drug.
摘要:
Disclosed is a suppository which includes two smooth-surfaced, body indissolvable bulbs approximately spherical or ellipsoidal in shape secured together by a body-indissolvable connecting member. The cross sectional area of the connecting member combined with any medication which may surround it is less than the combined cross sectional area of the bulbs and any medication which may surround them, so that when the suppository is inserted into the anal canal, the bulbs at each end straddle the anal sphincter muscles.