公开(公告)号：US11634464B2

公开(公告)日：2023-04-25

申请号：US16908179

申请日：2020-06-22

申请人： CHANG GUNG UNIVERSITY

发明人： Shin-Ru Shih ,  Yu-An Kung ,  Chuan-Tien Hung

IPC分类号： C07K14/47 ,  C12N15/86 ,  C12N7/00 ,  A61K39/125 ,  C07K14/005 ,  A61K39/12 ,  A61K39/00

摘要： Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.

公开(公告)号：US20230053908A1

公开(公告)日：2023-02-23

申请号：US17701757

申请日：2022-03-23

申请人： Chang Gung University

发明人： YA-JU CHANG ,  HSIAO-LUNG CHAN ,  JIUNN-WOEI LIAW ,  CHENG-CHUNG KUO

IPC分类号： A63B24/00 ,  A63B22/00 ,  A63B21/005

摘要： A training device and a training method for reducing hypertonic are disclosed. The training device includes a base, a driving circuit, two pedals, a control circuit, and a switch circuit. The driving circuit is fixed on the base. Each of the two pedals is coupled to the base. The driving circuit drives each of the two pedals to swing repeatedly between a first position and a second position relative to the base. When the control circuit executes a training program, the control circuit actuates the driving circuit.

公开(公告)号：US20220361839A1

公开(公告)日：2022-11-17

申请号：US17497281

申请日：2021-10-08

申请人： Chang Gung University

发明人： Po-Hsiang Tsui ,  Dar-In Tai

IPC分类号： A61B8/08 ,  G06N3/04

摘要： A non-invasive ultrasound detection device for detecting liver fibrosis and method thereof is disclosed. The method comprises the steps of: creating a discriminant function of several parameters, each with a weight obtained by LDA, based on a database; and determining the degree of liver fibrosis by comparing a reference value and a numerical value calculated from the discriminant function. The parameters represent different probability distribution functions capable of identifying liver fibrosis or fatty liver. In the step of creating a discriminant function, the database provides the processed data based on numerous ultrasound images of patents' livers for LDA. In the step of determining the degree of liver fibrosis, the processed data based on ultrasound images of a person's liver are obtained for further calculation of the numerical value. The processed data includes an average value for each probability distribution function within an area corresponding to a liver.

公开(公告)号：US20220339122A1

公开(公告)日：2022-10-27

申请号：US17241064

申请日：2021-04-27

申请人： Chang Gung University

发明人： Tsong-Long HWANG ,  Ting-I KAO ,  Tian-Shung WU

IPC分类号： A61K31/085 ,  A61P11/16

摘要： Disclosed herein is a method of treating diseases and/or disorders associated with the dysregulated activation and recruitment of neutrophils. The method includes administering to a subject in need thereof an effective amount of 3,3′-dihydroxy-2′,6′-bis(p-hydroxybenzyl)-5-methoxybibenzyl (or bletinib), a salt, a solvate or an ester thereof.

公开(公告)号：US20220260576A1

公开(公告)日：2022-08-18

申请号：US17228921

申请日：2021-04-13

申请人： Chang Gung University

发明人： Min-Hsien Wu ,  Po-Yu Chu

IPC分类号： G01N33/574 ,  G16H50/20 ,  G16H10/40

摘要： A cancer status prediction method and uses thereof, by analyzing specific cell information in blood samples and cancer clinical detection data with a cancer status analysis module to further perform cancer status prediction.

公开(公告)号：US11344193B2

公开(公告)日：2022-05-31

申请号：US16440173

申请日：2019-06-13

申请人： Chang Gung University

发明人： Jyh-Da Wei ,  Jerry Chien-Chieh Huang ,  Shin-Yi Chen

IPC分类号： A61B3/032 ,  G06F3/0482 ,  G16H10/20 ,  A61B3/00 ,  G06T13/80

摘要： A method for performing an assessment of vision is provided, and comprises: determining a current difficulty level for the assessment; displaying a question of the assessment, the question including a visual element that has a movable pattern, the movable pattern having at least one variable attribute that is related to the current difficulty level; in response to receipt of an inputted answer, determining whether the inputted answer is correct; and determining whether the assessment is to be concluded, and in the affirmative, generating a result of the assessment based on the current difficulty level.

公开(公告)号：US20220163839A1

公开(公告)日：2022-05-26

申请号：US17132383

申请日：2020-12-23

申请人： Chang Gung University of Science and Technology

发明人： Hsiu Min Tsai ,  Po Hsiang Huang

IPC分类号： G02F1/1335 ,  F21V8/00 ,  G02F1/13357

摘要： A robot using a liquid crystal display panel includes a mask, an LCD panel and a high-directional backlight module. The LCD is arranged close to the mask, and the backlight module is arranged on one side of the LCD panel and used to provide an extremely high directional backlight source to the liquid crystal display panel so that the image generated by the LCD panel can be projected onto the mask. By projecting images on the mask via the LCD panel, the disadvantage that the conventional projector needs to occupy a larger space is improved, and the design of the mask can be more flexible.

公开(公告)号：US11328791B2

公开(公告)日：2022-05-10

申请号：US16138449

申请日：2018-09-21

申请人： Chang Gung University ,  Chang Gung Memorial Hospital, Linkou

发明人： Pao-Hsien Chu ,  Yu-Sun Chang ,  Chia-Chun Chen ,  Pei-Chun Fan

IPC分类号： C12Q1/68 ,  G16B20/00 ,  G16B40/00 ,  C12Q1/6883 ,  G16B25/10 ,  G16B5/20

摘要： A method for determining a human subject's risk of developing acute kidney injury (AKI) from acute myocardial infarction (AMI) includes: obtaining a blood sample; determining at least two miRNA expression levels therein, which are selected from miR-23a-3p, miR-24-3p, and miR-145-5p expression levels; calculating probability of developing AKI from AMI based on the at least two miRNA expression levels and a logistic regression model; comparing the probability with a predetermined standard; and determining that the human subject is at the risk of developing AKI when the probability is higher than the predetermined standard. A composition may be administered to the human subject for inhibiting development of AKI, if any.

公开(公告)号：US20220074939A1

公开(公告)日：2022-03-10

申请号：US17470283

申请日：2021-09-09

申请人： CHANG GUNG UNIVERSITY ,  Chang Gung Memorial Hospital, Linkou

发明人： Shin-Ru SHIH ,  Kuan-Ting LIU ,  Guang-Wu CHEN ,  Chung-Guei HUANG ,  Kar-Yee YU ,  Hou-Chen LEE ,  Peng-Nien HUANG ,  Yu-Nong GONG ,  Rei-Lin KUO ,  Chih-Ching WU ,  Yu-An KUNG ,  Sheng-Yu HUANG

IPC分类号： G01N33/569 ,  G01N33/538 ,  G01N33/543

摘要： A method for determining immune competence against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) includes obtaining a blood sample from a subject in need thereof, detecting, in the blood sample, levels of binding antibodies against SARS-CoV-2 spike S1 protein and its receptor binding domain (RBD), and calculating a weighted value using a regression model. Another method for determining immune competence against SARS-CoV-2 is also disclosed.

公开(公告)号：US11262237B2

公开(公告)日：2022-03-01

申请号：US17130256

申请日：2020-12-22

申请人： Chang Gung University

发明人： Meng Tsan Tsai ,  Tai Ang Wang ,  Cheng Yu Lee

IPC分类号： G01J3/28 ,  G01J3/18 ,  G01J3/02

摘要： A spectral analysis device is provided herein. The spectral analysis device includes a first lens, a transmission grating, a lens set and a sensing element. The first lens is configured to receive and converge an incident light beam into a first light beam. The transmission grating is configured to disperse the first light beam into a plurality of second light beams. The lens set is configured to receive the plurality of second light beams. The sensing element includes a substrate and a plurality of pixels. The plurality of pixels is configured to respectively receive the plurality of second light beam. Such structure is used to analyze the spectrum of incident light.