公开(公告)号：US20230066255A1

公开(公告)日：2023-03-02

申请号：US17793208

申请日：2021-01-15

申请人： HORIBA ABX SAS ,  UNIVERSITE DE MONTPELLIER ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Pierre TARACONAT ,  Damien ISEBE ,  Simon MENDEZ ,  Franck NICOUD

IPC分类号： G01N15/12 ,  G01N33/487

摘要： A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

公开(公告)号：US20230044444A1

公开(公告)日：2023-02-09

申请号：US17931725

申请日：2022-09-13

申请人： VOYAGER THERAPEUTICS, INC. ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITÉ DE STRASBOURG

发明人： Dinah Wen-Yee Sah ,  Martin Goulet ,  Holger Patzke ,  Yanqun Shu ,  Jinzhao Hou ,  Hélène Puccio

IPC分类号： C12N15/86 ,  A61P25/00 ,  A61K48/00 ,  C07K14/47 ,  C12N7/00

摘要： Described herein are compositions and methods for treating Friedreich's Ataxia (FA) using adeno-associated virus (AAV) to deliver therapeutics agents.

公开(公告)号：US20230032690A1

公开(公告)日：2023-02-02

申请号：US17818481

申请日：2022-08-09

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE LILLE ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Luc BUEE ,  Malika HAMDANE ,  David BLUM ,  Maxime DERISBOURG ,  Coline LEGHAY ,  Giovanni CHIAPPETTA ,  Joelle VINH ,  Yann VERDIER

IPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/68

摘要： The invention relates to the identification of a new Tau species starting at residue Met11 (Met11-Tau) which is N-alpha-terminally acetylated form (N-alpha-acetyl-Met11-Tau species: Ac-Met11-Tau). Several monoclonal antibodies specific of this new Tau species have been developed. One of this antibody, 2H2/D11, was used in THY-Tau22 mouse model (that develops with age neurofibrillary degeneration (NFD) and memory deficits), and N-alpha-Ac-Met11-Tau species were clearly detected early in neurons displaying NFD on hippocampal brain sections while it is not reactive in hippocampus from elderly controls. Finally, by using ELISA sandwich specific of Ac-Met11-Tau species, Alzheimer Disease (AD) brain samples are clearly discriminated from human elderly control brains. Thus the invention relates to this new Tau species starting from the methionine residue at position 11 said methionine being N-alpha acetylated. The invention also relates to antibody that specifically binds this new tau species, a method of detection of this new Tau species and a method of diagnosis of Tauopathy disorder.

公开(公告)号：US20230028731A1

公开(公告)日：2023-01-26

申请号：US17783451

申请日：2020-12-09

申请人： INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS

发明人： ADRIEN LEBLANC ,  PHILIPPE LASSONDE ,  FRANCOIS LEGARE

IPC分类号： H01S3/13 ,  H01S3/00 ,  G01J11/00

摘要： A method and a system for measuring carrier-to-envelope phase fluctuations (CEP) fluctuations of a laser field, the method comprising focusing laser pulses in a solid-state material for high harmonic generation, collecting a resulting high harmonic spectrum, and inferring a relative phase of the driving field from the high harmonic spectrum. The system comprises a source of CEP stable mid-infrared laser pulses; a CEP variation unit; a solid state medium; a detector; and first focusing optics focusing pulses generated by the source into the solid state medium and second focusing optics collecting resulting harmonics generated in the solid state medium into the detector.

公开(公告)号：US20230016226A1

公开(公告)日：2023-01-19

申请号：US17619479

申请日：2020-06-12

申请人： Arkema France ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite d'Aix-Marseille

发明人： Georges Fremy ,  Hugo Brasselet ,  Véronique Alphand ,  Katia Duquesne

IPC分类号： C12P17/00 ,  C12P11/00 ,  C12N9/02 ,  C12N9/04

摘要： The present invention relates to a selective process for preparing sulfones from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfone; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.

公开(公告)号：US20220397722A1

公开(公告)日：2022-12-15

申请号：US17765671

申请日：2020-10-12

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS - ,  UNIVERSITE DE FRANCHE COMTE

发明人： Jean-Charles BEUGNOT ,  Jacques CHRETIEN ,  Adrien GODET

IPC分类号： G02B6/28 ,  G02B6/30

摘要： A process for delaying a useful optical signal (P1) having a wavelength value λ between 0.2 μm and 3 μm, with respect to a reference optical signal (P2) having the same wavelength value λ. The process includes having the useful optical signal propagate along a tapered fiber portion. A length of the tapered fiber portion can be varied using stretching means that are light, less cumbersome and less expensive compared to those necessary for a standard optical fiber. In addition, the delay value which is effective for the useful optical signal can be varied over a wide range. Such process can be useful for interferometry measurements in particular.

公开(公告)号：US20220390458A1

公开(公告)日：2022-12-08

申请号：US17762664

申请日：2020-09-22

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  CPE LYON FORMATION CONTINUE ET RECHERCHE pouvant être précédée ou suivie par CPE LYON FCR ,  CENTRE LEON BERARD ,  HOSPICES CIVILS DE LYON

发明人： Thierry GRANJON ,  Ofelia MANITI ,  Olivier MARCILLAT ,  Peter GOEKJIAN ,  Mouhedine CHENIOUR ,  Arnaud VIGNERON ,  David GUEYRARD ,  Sébastien IBANEZ

IPC分类号： G01N33/58 ,  C09B57/00 ,  G01N33/574 ,  G01N21/64

摘要： The invention relates a fluorescent compound of formula I: wherein A is selected from P, P═O and N; ·R1 is a residue comprising an oxygen atom·R2 is a residue comprising an oxygen atom, or a halogen, ·R3, R4 and R5 are alkyls, possibly substituted or a salt or a solvate thereof. The compound is useful as a fluorescent probe sensitive to membrane fluidity and for diagnosing cancer.

公开(公告)号：US11521745B2

公开(公告)日：2022-12-06

申请号：US16763815

申请日：2018-11-14

申请人： Universite Paris-SUD ,  Universite De Paris ,  Institut National De Sport De L'Expertise Et De La Performance ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Geoffroy Berthelot ,  Jérôme Dedecker ,  Guillaume Sauliere

IPC分类号： G01N33/48 ,  G01N33/50 ,  G16H50/20 ,  G16H50/30 ,  G06F17/18 ,  A61B5/00

摘要： The invention proposes a new method for monitoring a health event in a mammal, comprising detecting at least one abnormal value within a series of values related to at least one biomarker, based on appropriate Z-scores.

公开(公告)号：US11510896B2

公开(公告)日：2022-11-29

申请号：US16340346

申请日：2017-10-20

申请人： UNIVERSITE CLAUDE BERNARD LYON 1 ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Manuel Rosa-Calatrava ,  Olivier Terrier ,  Anaïs Proust ,  Vincent Moules

IPC分类号： A61K31/353 ,  A61P31/14 ,  A61K9/00 ,  A61K31/35 ,  A61K31/4375 ,  A61K31/7056 ,  A61K38/21 ,  A61K31/351 ,  A61K31/352 ,  A61K45/06

摘要： The present invention relates to a pharmaceutical or veterinary composition for its use in preventing and/or treating a MERS-CoV (Middle-East Respiratory Syndrome) coronavirus infection, characterised in that it comprises, in a suitable pharmaceutical vehicle, at least one compound chosen from apigenin and berberine.

公开(公告)号：US20220363556A1

公开(公告)日：2022-11-17

申请号：US17768391

申请日：2020-10-13

申请人： TotalEnergies OneTech ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Svetlana MINTOVA ,  Jean-Pierre GILSON ,  Nikolai NESTERENKO ,  Delphine MINOUX ,  Cindy AQUINO ,  Julien GRAND ,  Florent DUBRAY

IPC分类号： C01B39/48

摘要： The present disclosure relates to a novel staged-synthesis method for introduction of various metals in the structure of zeolite frameworks by isomorphous substitution. This new method is based on a hydrothermal synthesis in which the metal addition to the precursor suspensions (gel) is delayed. This so-called “staged-synthesis method” allows to obtain nanosized silanol highly homo- geneous crystalline zeolite structures with a control of the metal location.