公开(公告)号：US20220062298A1

公开(公告)日：2022-03-03

申请号：US17325925

申请日：2021-05-20

Applicant: KUWAIT UNIVERSITY

Inventor： AHMED EL-HASHIM ,  KHALED ORABI ,  MAITHAM ABBAS KHAJAH

IPC: A61K31/573 ,  A61K36/8962 ,  A61P11/06 ,  A61P29/00

Abstract: The anti-inflammatory composition may be administered to a subject in need thereof to prevent or reduce inflammation, including inflammation resulting from asthma. The anti-inflammatory composition may comprise both onion bulb extract and one or more glucocorticosteroids, particularly a low-dose glucocorticosteroid. The anti-inflammatory composition may be administered to a subject at risk of developing asthma to prevent the progression of asthma. The anti-inflammatory composition may act by reducing pEGFR levels, or by inhibiting other inflammatory pathways.

公开(公告)号：US20210322504A1

公开(公告)日：2021-10-21

申请号：US17362707

申请日：2021-06-29

Applicant: KUWAIT UNIVERSITY

Inventor： MOHAMMAD ABDULRAHMAN ALI ALANSARI

IPC: A61K36/487 ,  A61P17/00 ,  A61K9/00 ,  A61K36/185 ,  A61K36/23 ,  A61K36/28 ,  A61K36/29 ,  A61K36/482 ,  A61N5/06

Abstract: A first embodiment of a composition for treating vitiligo includes Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, and Psoralea corylifolia black seed powder. A second embodiment of a composition for treating vitiligo can include Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, Berberries (or Berberis) vulgaris root powder, red clay (with trace copper), and Ptycholis verlicillata root powder. Topical administration of the first composition followed by UV radiation exposure can facilitate inducing melanogenesis as well as generating ROS. Topical administration of the second composition following the UV radiation exposure can scavenge the ROS generated by the first composition.

公开(公告)号：US10723694B2

公开(公告)日：2020-07-28

申请号：US16149317

申请日：2018-10-02

Applicant: KUWAIT UNIVERSITY

Inventor： Saad A. Makhseed ,  Ali A. Husain ,  Asaithampi Ganesan ,  Mahmut Durmus

IPC: C07C255/54 ,  C07F3/06 ,  A61P35/00

Abstract: Propargyl-functionalized macrocyclic compounds can include non-aggregating compounds having at least one phthalocyanine (Pc), azaphthalocyanine (AzaPc), or naphthalocyanine (Nc) unit. The compounds can be metal-free or metal-complexed. The metal-complexed compounds can include zinc (II), for example. The compounds can include multiple propargyl moieties at different sites, e.g., peripheral or non-peripheral sites, as described herein. Exemplary compounds include an azaphthalocyanine complex (AzaPc1) and phthalocyanine complexes (Pc2-Pc5). The compounds may provide efficient solubility in aqueous and/or organic solvents, optimal physicochemical properties, improved photo-sensitizability, significant tumor specificity, and electron transfer tunability. The compounds can provide suitable non-aggregated molecular scaffolds for construction of numerous macrocycle derivatives via different organic transformation methodologies, e.g., Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC).

公开(公告)号：US20200103324A1

公开(公告)日：2020-04-02

申请号：US16145097

申请日：2018-09-27

Applicant: KUWAIT UNIVERSITY

Inventor： BADER AL-ANZI

IPC: G01N11/02 ,  B01F3/04 ,  B01F15/00

Abstract: The apparatus for measuring disentrainment rate of air includes a Confined Plunging Liquid Jet Reactor (CPLJR) having a downcomer column surrounding a liquid jet. The end of the downcomer column is partially immersed in a receiving liquid pool contained in a reservoir. A conical ring is placed in the downcomer column below the liquid jet, the ring bearing against the wall of the downcomer column and forming a seal to define a headspace in the column. A gas supply and first bubble meter are connected to the column above the conical ring to supply gas and measure total entrainment. A second bubble meter connected to the headspace between the ring and the receiving pool measures disentrainment, and a third bubble meter connected to headspace above the receiving pool outside the column measures net entrainment.

公开(公告)号：US20200102267A1

公开(公告)日：2020-04-02

申请号：US16149317

申请日：2018-10-02

Applicant: KUWAIT UNIVERSITY

Inventor： SAAD A. MAKHSEED ,  ALI A. HUSAIN ,  ASAITHAMPI GANESAN ,  MAHMUT DURMUS

IPC: C07C255/54 ,  A61P35/00 ,  C07F3/06

Abstract: Propargyl-functionalized macrocyclic compounds can include non-aggregating compounds having at least one phthalocyanine (Pc), azaphthalocyanine (AzaPc), or naphthalocyanine (Nc) unit. The compounds can be metal-free or metal-complexed. The metal-complexed compounds can include zinc (II), for example. The compounds can include multiple propargyl moieties at different sites, e.g., peripheral or non-peripheral sites, as described herein. Exemplary compounds include an azaphthalocyanine complex (AzaPc1) and phthalocyanine complexes (Pc2-Pc5). The compounds may provide efficient solubility in aqueous and/or organic solvents, optimal physicochemical properties, improved photo-sensitizability, significant tumor specificity, and electron transfer tunability. The compounds can provide suitable non-aggregated molecular scaffolds for construction of numerous macrocycle derivatives via different organic transformation methodologies, e.g., Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC).

公开(公告)号：US20200085899A1

公开(公告)日：2020-03-19

申请号：US16134092

申请日：2018-09-18

Applicant: KUWAIT UNIVERSITY

Inventor： MOHAMMAD ABDULRAHMAN ALI ALANSARI

IPC: A61K36/487 ,  A61K36/482 ,  A61K36/28 ,  A61K36/185 ,  A61K36/29 ,  A61K36/23 ,  A61K9/00 ,  A61P17/00 ,  A61N5/06

Abstract: A first embodiment of a composition for treating vitiligo includes Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, and Psoralea corylifolia black seed powder. A second embodiment of a composition for treating vitiligo can include Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, Berberries (or Berberis) vulgaris root powder, red clay (with trace copper), and Ptychotis verticillata root powder. Topical administration of the first composition followed by UV radiation exposure can facilitate inducing melanogenesis as well as generating ROS. Topical administration of the second composition following the UV radiation exposure can scavenge the ROS generated by the first composition.

公开(公告)号：US10087487B2

公开(公告)日：2018-10-02

申请号：US14481884

申请日：2014-09-09

Applicant: KUWAIT UNIVERSITY

Inventor： Fahd Al-Mulla ,  Jean Paul Thiery ,  Milad S. Bitar

IPC: C12P19/34 ,  C12Q1/6886

Abstract: The method for determining risk of metastatic relapse in a patient diagnosed with colorectal cancer (CRC) can include detecting a level of at least one indicator of metastatic potential in a biological sample from the patient, comparing the level of the indicator of metastatic potential with a control, and identifying the patient as one who is at risk of metastatic relapse and a candidate for chemotherapy if an aberrant level of the indicator of metastatic potential in the biological sample compared to the control is detected. The at least one indicator of metastatic potential can include at least one metastasis-inducing gene and/or at least one metastasis suppressor gene. An aberrant level of the at least one indicator of metastatic potential can include a copy number gain of the metastasis-inducing gene and/or a copy number loss of the metastasis-suppressor gene.

公开(公告)号：US10085394B2

公开(公告)日：2018-10-02

申请号：US15209536

申请日：2016-07-13

Applicant: KUWAIT UNIVERSITY

Inventor： Fawaz Shukhier Al-Anzi

IPC: A01G13/02 ,  A01G9/02 ,  A01G25/00 ,  A01G27/02 ,  A01G27/00 ,  A01G9/00

Abstract: The planter system using waste materials repurpose waste materials to construct a self-irrigating planter that promotes plant growth in a protective environment. The planter system includes a water reservoir constructed from scrap tire defining a hollow interior serving as water storage, the reservoir being buried in soil. A condensation funnel having a sloped condensation skirt extends into the center opening of the scrap tire to direct condensate into the water reservoir. A root ball cover made from scrap newspaper covers the root system of a plant, and the plant is buried in the center opening of the scrap tire. A soil protection cover is placed atop the root ball cover to protect the soil of the root ball, and a support tube extends therefrom to protect the stem of the plant from environmental conditions. A valve regulates delivery of water to the reservoir. Most components are made from scrap plastic.

公开(公告)号：US20180014482A1

公开(公告)日：2018-01-18

申请号：US15209536

申请日：2016-07-13

Applicant: KUWAIT UNIVERSITY

Inventor： FAWAZ SHUKHIER AL-ANZI

IPC: A01G27/02 ,  A01G13/02 ,  A01G27/00

CPC classification number: A01G27/02 ,  A01G9/00 ,  A01G13/0237 ,  A01G13/0281 ,  A01G27/008

Abstract: The planter system using waste materials repurpose waste materials to construct a self-irrigating planter that promotes plant growth in a protective environment. The planter system includes a water reservoir constructed from scrap tire defining a hollow interior serving as water storage, the reservoir being buried in soil. A condensation funnel having a sloped condensation skirt extends into the center opening of the scrap tire to direct condensate into the water reservoir. A root ball cover made from scrap newspaper covers the root system of a plant, and the plant is buried in the center opening of the scrap tire. A soil protection cover is placed atop the root ball cover to protect the soil of the root ball, and a support tube extends therefrom to protect the stem of the plant from environmental conditions. A valve regulates delivery of water to the reservoir. Most components are made from scrap plastic.

公开(公告)号：US20170298474A1

公开(公告)日：2017-10-19

申请号：US15131603

申请日：2016-04-18

Applicant: KUWAIT UNIVERSITY

Inventor： MAGDY S. MONTASSER ,  ASHRAF M. YOUNES ,  AYMAN E. EL-SHARKAWEY

IPC: C22B3/00 ,  B22F1/00 ,  C22B7/00

CPC classification number: C22B11/04 ,  B22F1/0018 ,  B22F1/0044 ,  B22F9/24 ,  B22F2001/0037 ,  B22F2301/255 ,  B22F2304/054 ,  C22B7/007 ,  Y02P10/238

Abstract: A method for preparing gold metal nanoparticles, e.g., nanospheres and nanoprisms, includes combining an extract of red algae with chloroauric acid (HAuCl4). The red algae can be Laurencia papillosa. The extract can include a water solvent extract. The chloroauric acid (HAuCl4) can be in an aqueous solution. The method can include providing chloroauric acid(HAuCl4), providing a red algae extract, and combining the chloroauric acid (HAuCl4) and the red algae extract to produce gold nanoparticles.