公开(公告)号：US20180244770A1

公开(公告)日：2018-08-30

申请号：US15756043

申请日：2016-08-26

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Francesca AVOGADRI-CONNORS ,  William MONTEITH

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2803 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.