公开(公告)号：US20190002560A1

公开(公告)日：2019-01-03

申请号：US15735947

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Kate MONROE ,  Helen LAM ,  Francesca AVOGADRI-CONNORS ,  Seung-Joo LEE ,  William MONTEITH ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220411503A1

公开(公告)日：2022-12-29

申请号：US17831336

申请日：2022-06-02

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Francesca AVOGADRI-CONNORS ,  William MONTEITH

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210317208A1

公开(公告)日：2021-10-14

申请号：US17272083

申请日：2019-08-30

Applicant: Alector LLC

Inventor： Patricia CULP ,  Helen LAM ,  Wei-Hsien HO ,  Leonard G. PRESTA ,  Arnon ROSENTHAL

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a CD33 polypeptide, e.g., a mammalian CD33 or human CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210246204A1

公开(公告)日：2021-08-12

申请号：US16972840

申请日：2019-06-07

Applicant: Alector LLC

Inventor： Patricia CULP ,  Seung-Joo LEE ,  Helen LAM ,  Wei-Hsien HO ,  Arnon ROSENTHAL

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20250145709A1

公开(公告)日：2025-05-08

申请号：US19015556

申请日：2025-01-09

Applicant: Alector LLC

Inventor： Patricia CULP ,  Seung-Joo LEE ,  Helen LAM ,  Wei-Hsien HO ,  Arnon ROSENTHAL

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210017275A1

公开(公告)日：2021-01-21

申请号：US16614302

申请日：2018-05-15

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Patricia CULP ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P37/00 ,  A61P25/00 ,  A61P25/28 ,  A61P25/08 ,  A61P31/04 ,  A61P29/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190330335A1

公开(公告)日：2019-10-31

申请号：US15766363

申请日：2016-10-06

Applicant: ALECTOR LLC

Inventor： Tina SCHWABE ,  Francesca AVOGADRI-CONNORS ,  Helen LAM ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220251190A1

公开(公告)日：2022-08-11

申请号：US17459835

申请日：2021-08-27

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Francesca AVOGADRI-CONNORS ,  Seung-Joo LEE ,  William MONTEITH ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20200277374A1

公开(公告)日：2020-09-03

申请号：US16792040

申请日：2020-02-14

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Francesca AVOGADRI-CONNORS ,  William MONTEITH

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20180244770A1

公开(公告)日：2018-08-30

申请号：US15756043

申请日：2016-08-26

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Francesca AVOGADRI-CONNORS ,  William MONTEITH

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2803 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.