公开(公告)号：US4736067A

公开(公告)日：1988-04-05

申请号：US647755

申请日：1984-09-06

Applicant: Andree Bugaut ,  Alain Genet ,  Jean Cotteret ,  Alex Junino

Inventor： Andree Bugaut ,  Alain Genet ,  Jean Cotteret ,  Alex Junino

IPC: A61K8/00 ,  A61K20060101 ,  A61K8/34 ,  A61K8/35 ,  A61K8/40 ,  A61K8/41 ,  A61Q5/06 ,  A61Q5/10 ,  C07C20060101 ,  C07C67/00 ,  C07C209/00 ,  C07C209/08 ,  C07C209/18 ,  C07C209/36 ,  C07C209/60 ,  C07C209/62 ,  C07C211/52 ,  C07C215/16 ,  C09B51/00 ,  C09B53/00 ,  C09B67/42 ,  D06P1/32 ,  D06P1/42 ,  D06P3/08 ,  C07C87/58 ,  A61K7/13 ,  C07C87/28

CPC classification number: A61K8/418 ,  A61Q5/065 ,  A61Q5/10

Abstract: New dimethyl derivatives of 3-nitro-4-aminoaniline, process for their preparation, and their use for dyeing keratinic fibres.The invention relates to dimethyl derivatives of 3-nitro-4-aminoaniline of formula: ##STR1## in which CH.sub.3 is in position 2 or 5 of the benzene ring and R.sub.1 and R.sub.2 denote independently of each other a hydrogen atom, a lower alkyl group, a lower mono- or polyhydroxyalkyl or a lower aminoalkyl group in which the amino group is optionally mono- or disubstituted by a lower alkyl radical or by a lower mono- or polyhydroxyalkyl radical, it being understood that the two symbols R.sub.1 and R.sub.2 can be simultaneously other than hydrogen only when the mobile CH.sub.3 radical is in position 5, or cosmetically acceptable salts of these compounds, as well as the process for preparing them and their use in dye compositions, in particular for hair, equally for direct coloring and for coloring by an oxidation route.

Abstract translation: 3-硝基-4-氨基苯胺的新二甲基衍生物，其制备方法及其用于染色角蛋白纤维的用途。 本发明涉及下列结构式的3-硝基-4-氨基苯胺的二甲基衍生物：其中CH 3位于苯环的2或5位，R 1和R 2彼此独立地表示氢原子，低级烷基 ，低级单羟基烷基或多羟基烷基或低级氨基烷基，其中氨基任选被低级烷基或低级单羟基或多羟基烷基单取代或二取代，应理解，两个符号R1和R2可以是 同时除了氢，只有当可移动的CH3基团在5位时，或这些化合物的美容上可接受的盐，以及它们的制备方法以及它们在染料组合物中的用途，特别是用于毛发，同样用于直接着色和着色 通过氧化路线。

公开(公告)号：US4716710A

公开(公告)日：1988-01-05

申请号：US880823

申请日：1986-07-01

Applicant: Michel Galy ,  Alain Genet

Inventor： Michel Galy ,  Alain Genet

IPC: A61M5/178 ,  A61M5/00 ,  A61M5/31 ,  B65B31/00 ,  B67B3/24

CPC classification number: A61M5/00 ,  Y10T29/49872

Abstract: Process for the preparation in a series of self-injectable syringes characterized mainly by the fact that multiple seal tubes are placed vertically on an appropriate support, that a syringe body is placed vertically in each seal tube, that, into each tubular body thus arranged, a single dose of the medication in solution in a solvent is placed in each seal tube, above the syringe body, a plunger suspended by its pusher in a movable manner, at the lower end of a stopper which can adapt to the seal tube, so that said plunger is essentially in the axis of the syringe body and the lower end of said plunger is located above the upper end of the syringe body, with said stopper being held in a position so that said seal tube is not blocked or is not entirely blocked, to thus obtain an assembly constituting an open system in which the internal space, in the seal tubes and above said solution in the syringe bodies, is connected with the outside of the system, that the lyophilization operation is effected and, at this time, downward vertical pressure applied to the stoppers so that said stoppers completely block said seal tubes while said plungers, fastened to said stoppers, are introduced into the tubular bodies until the predetermined maximum insertion position is reached; a device and stopper for the implementation of said process.

Abstract translation: 一系列自注射式注射器的制备方法，其特征在于主要是将多个密封管垂直放置在适当的支撑体上，使注射器主体垂直地放置在每个密封管中，使其进入如此布置的每个管状体中， 在溶剂溶液中的单次剂量的药物被放置在注射器主体上方的每个密封管中，可移动地悬挂在其上的推杆的柱塞在可适应密封管的塞子的下端，因此 所述柱塞基本上在注射器主体的轴线上，并且所述柱塞的下端位于注射器主体的上端之上，其中所述止动器保持在使得所述密封管不被阻塞或不完全的位置 阻塞，从而获得构成开放系统的组件，其中在密封管中和注射器主体中的上述溶液上的内部空间与系统的外部连接，冷冻干燥操作i 此时，向止动件施加向下的垂直压力，使得所述止动件完全阻挡所述密封管，同时将固定到所述止动件上的所述柱塞引入所述管状体中直到达到所述预定的最大插入位置; 用于实现所述过程的装置和塞子。