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70 条记录 (耗时 0.039 秒)

    Pegylated factor VIII
    62.
    发明授权
    Pegylated factor VIII 有权
    聚乙二醇化因子VIII

    公开(公告)号：US08053561B2

    公开(公告)日：2011-11-08

    申请号：US12719265

    申请日：2010-03-08

    申请人： Juergen Siekmann ,  Katalin Varadi ,  Herbert Gritsch ,  Peter Turecek

    发明人： Juergen Siekmann ,  Katalin Varadi ,  Herbert Gritsch ,  Peter Turecek

    IPC分类号： A61K38/00 ,  A61K38/37 ,  C07K14/435 ,  C07K14/755

    CPC分类号： C07K14/755 ,  A61K47/60 ,  C07K14/745

    摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.

    摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。

    Polymer-Von Willebrand Factor-Conjugates
    65.
    发明申请
    Polymer-Von Willebrand Factor-Conjugates 有权
    聚合物Von Willebrand因子 - 缀合物

    公开(公告)号：US20110111455A1

    公开(公告)日：2011-05-12

    申请号：US13007208

    申请日：2011-01-14

    申请人： Friedrich Scheiflinger ,  Peter Turecek ,  Juergen Siekmann

    发明人： Friedrich Scheiflinger ,  Peter Turecek ,  Juergen Siekmann

    IPC分类号： C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/755 ,  A61K47/60 ,  C07K14/775

    摘要： The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.

    摘要翻译： 本发明涉及包含血浆和/或重组血管性血友病因子（VWF）的蛋白质构建体（也称为聚合物-WWF-缀合物），所述VWF结合至少一个生理上可接受的聚合物分子，以及与复合物 在所述蛋白质构建体和至少一种因子VIII（FVIII）蛋白之间。 生理上可接受的聚合物分子可以是例如聚乙二醇（PEG）或聚唾液酸（PSA）。 此外，本发明涉及用于延长具有与FVIII或VWF中的至少一种的功能缺陷或缺陷相关的出血性疾病的哺乳动物的血液中VWF或FVIII的体内半衰期的方法。

    Pegylated factor VIII
    68.
    发明授权
    Pegylated factor VIII 有权
    聚乙二醇化因子VIII

    公开(公告)号：US07683158B2

    公开(公告)日：2010-03-23

    申请号：US11729625

    申请日：2007-03-29

    申请人： Juergen Siekmann ,  Katalin Varadi ,  Herbert Gritsch ,  Peter Turecek

    发明人： Juergen Siekmann ,  Katalin Varadi ,  Herbert Gritsch ,  Peter Turecek

    IPC分类号： C07K14/745

    CPC分类号： C07K14/755 ,  A61K47/60 ,  C07K14/745

    摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.

    摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。

    Hydrolysable polymeric FMOC- linker
    69.
    发明申请
    Hydrolysable polymeric FMOC- linker 有权
    可水解的聚合物FMOC-接头

    公开(公告)号：US20090005542A1

    公开(公告)日：2009-01-01

    申请号：US12215218

    申请日：2008-06-25

    申请人： Peter Turecek ,  Juergen Siekmann

    发明人： Peter Turecek ,  Juergen Siekmann

    IPC分类号： C07D207/40 ,  C08B37/00 ,  C07K14/00

    CPC分类号： A61K47/61

    摘要： The invention relates to Fmoc (9-fluorenyl-methoxycarbonyl)-based polymeric conjugates. These conjugates are useful for extending the in-vivo circulation of protein and peptide drugs.

    摘要翻译： 本发明涉及Fmoc（9-芴基 - 甲氧基羰基）基聚合物共轭物。 这些缀合物可用于延长蛋白质和肽类药物的体内循环。

    Polymer-von Willebrand factor-conjugates
    70.
    发明申请
    Polymer-von Willebrand factor-conjugates 有权

    公开(公告)号：US20060160948A1

    公开(公告)日：2006-07-20

    申请号：US11317582

    申请日：2005-12-23

    申请人： Friedrich Scheiflinger ,  Peter Turecek ,  Juergen Siekmann

    发明人： Friedrich Scheiflinger ,  Peter Turecek ,  Juergen Siekmann

    IPC分类号： A61K38/37 ,  C07K14/775

    CPC分类号： C07K14/755 ,  A61K47/60 ,  C07K14/775

    摘要： The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.