公开(公告)号：US20090280167A1

公开(公告)日：2009-11-12

申请号：US12436937

申请日：2009-05-07

申请人： Vuong Trieu ,  Larn Hwang ,  Neil Desai

发明人： Vuong Trieu ,  Larn Hwang ,  Neil Desai

IPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K39/395 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12N15/111 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2330/10

摘要： This invention provides methods and compositions for screening of microRNA capable of modulating gene expression in the apoptotic pathway in the presence of HSP90 inhibitor. The use of miRNA for enhancing the activity of therapeutic agents not limited to HSP90 inhibitor is also disclosed. The diagnostic use of miRNA for predicting response to therapy not limited to therapeutic agents is also disclosed. A method for the identification and therapeutic application of small molecules which are modulators of these nucleic acids are also included in this application

摘要翻译： 本发明提供了在HSP90抑制剂存在下筛选能够调节凋亡途径中的基因表达的微小RNA的方法和组合物。 还公开了miRNA用于增强不限于HSP90抑制剂的治疗剂的活性的用途。 还公开了miRNA用于预测对治疗的反应的诊断用途，不限于治疗剂。 用于鉴定和治疗应用这些核酸调节剂的小分子的方法也包括在本申请中

公开(公告)号：US20070117133A1

公开(公告)日：2007-05-24

申请号：US11599100

申请日：2006-11-14

申请人： Vuong Trieu ,  Neil Desai ,  Patrick Soon-Shiong

发明人： Vuong Trieu ,  Neil Desai ,  Patrick Soon-Shiong

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： A61K31/337 ,  A61K38/38 ,  A61K47/643 ,  A61K47/6929 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/574 ,  G01N33/5743 ,  G01N33/57488 ,  G01N2333/4727 ,  G01N2800/52 ,  Y10T436/25

摘要： The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.

摘要翻译： 本发明提供用于预测或确定哺乳动物肿瘤对化学治疗剂的反应和用于治疗哺乳动物肿瘤的方法，包括检测和定量分离自哺乳动物的样品中的SPARC蛋白或RNA。 本发明还提供了用于预测哺乳动物肿瘤对化学治疗剂的反应的试剂盒，其包括用于从肿瘤分离蛋白质或RNA的手段，SPARC蛋白或RNA检测和定量方法，控制RNA和用于预测 基于肿瘤中SPARC蛋白或RNA水平的肿瘤反应。