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61.发明申请SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开取代的嘌呤 - 吡嗪衍生物及其作为钾通道调节剂的用途公开(公告)号：US20110237607A1
公开(公告)日：2011-09-29
申请号：US13120845
申请日：2009-09-22
IPC分类号： A61K31/52 , C07D473/34 , A61P11/00 , A61P25/08 , A61P13/10 , A61P9/10 , A61P25/16 , A61P25/14 , A61P25/18 , A61P25/28 , A61P1/00
CPC分类号： C07D473/16
摘要： This invention relates to novel substituted purinyl-pyrazol derivatives (I) and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译： 本发明涉及新的取代的嘌呤基 - 吡唑衍生物（I）及其作为钾通道调节剂的用途。 此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。
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62.发明申请PYRAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 有权吡咯并吡啶衍生物及其作为钾通道调节剂的用途公开(公告)号：US20110230484A1
公开(公告)日：2011-09-22
申请号：US13061347
申请日：2009-08-26
IPC分类号： A61K31/5377 , C07D413/14 , A61P11/00 , A61P25/08 , A61P13/10 , A61P13/02 , A61P15/10 , A61P1/00 , A61P1/12 , A61P9/00 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/16 , A61P25/28 , A61P3/10 , A61P35/00 , A61P37/06 , A61P29/00
CPC分类号： C07D403/04
摘要： This invention relates to novel pyrazolyl-pyrimidine derivatives and their use as potassium channel modulating agents. In another aspect the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译： 本发明涉及新的吡唑基 - 嘧啶衍生物及其作为钾通道调节剂的用途。 在另一方面，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。
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公开(公告)号：US07851492B2
公开(公告)日：2010-12-14
申请号：US10570250
申请日：2004-09-06
申请人： Søren Peter Olesen , Morten Grunnet , Palle Christophersen , Dorte Strøbæk , Joachim Demnitz , Rie S. Hansen
发明人： Søren Peter Olesen , Morten Grunnet , Palle Christophersen , Dorte Strøbæk , Joachim Demnitz , Rie S. Hansen
IPC分类号： A61K31/4245 , A61K31/4196 , A61K31/41 , A61K31/17
摘要： This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.
摘要翻译： 本发明涉及ERG通道开放剂用于治疗心律失常的用途，以及使用特定化合物进行这种治疗。 在另一方面，本发明提供了可用作ERG通道开放剂的新化合物。
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公开(公告)号：US20100286161A1
公开(公告)日：2010-11-11
申请号：US12678244
申请日：2008-09-16
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
IPC分类号： A61K31/497 , C07D403/04 , A61P3/10 , A61P35/00 , A61P25/28 , A61P9/10 , A61P15/00 , A61P25/22 , A61P25/32 , A61P25/24 , A61P25/18 , A61P9/12
CPC分类号： C07D403/04 , C07D401/04 , C07D405/14 , C07D417/04
摘要： This invention relates to novel pyrazine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译： 本发明涉及新颖的吡嗪衍生物及其作为钾通道调节剂的用途。 此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。
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公开(公告)号：US20100160315A1
公开(公告)日：2010-06-24
申请号：US12601124
申请日：2008-05-22
申请人： Carsten Jessen , William Dalby Brown , Joachim Demnitz , Dorte Strobaek , Mads P.G. Korsgaard , Palle Christophersen
发明人： Carsten Jessen , William Dalby Brown , Joachim Demnitz , Dorte Strobaek , Mads P.G. Korsgaard , Palle Christophersen
IPC分类号： A61K31/517 , C07D239/95 , C07D403/02 , C07D413/02 , A61K31/5377 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/02
CPC分类号： C07D239/95 , C07D403/04 , C07D405/12
摘要： This invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the 2,3-diamino-quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2,3-diamino-quinazolinone derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.
摘要翻译： 本发明涉及具有医疗效用的新的2,3-二氨基 - 喹唑啉酮衍生物，其用于制备药物的2,3-二氨基 - 喹唑啉酮衍生物，包含2,3-二氨基 - 本发明的喹唑啉酮衍生物，以及治疗受试者的疾病，疾病或病症的方法，所述疾病，疾病或病症对Kv7通道的激活有反应。
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公开(公告)号：US20100137381A1
公开(公告)日：2010-06-03
申请号：US12598541
申请日：2008-04-29
申请人： Antonio Nardi , Morten Grunnet , Palle Christophersen , Joachim Demnitz , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Palle Christophersen , Joachim Demnitz , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/4245 , C07D257/04 , A61K31/41 , C07D271/06 , A61P3/10 , A61P9/10 , A61P9/00 , A61P9/06 , A61P35/00 , A61P25/06 , A61P25/16 , A61P25/28 , A61P25/22 , A61P25/24
CPC分类号： C07D257/04 , C07D271/07
摘要： This invention relates to novel acetamide derivatives that are found to be potent modulators of ion channels, in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及被发现是离子通道，特别是钾通道和氯化物通道的有效调节剂的新型乙酰胺衍生物，因此，作为治疗疾病或病症的有价值的候选物，其对于对 调节钾通道。
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公开(公告)号：US20100130516A1
公开(公告)日：2010-05-27
申请号：US12593152
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
IPC分类号： A61K31/52 , C07D473/34 , A61P11/00 , A61P25/08 , A61P13/12 , A61P13/10 , A61P15/10 , A61P9/10 , A61P25/16 , A61P25/28 , A61P25/18 , A61P25/06
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
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公开(公告)号：US20100105705A1
公开(公告)日：2010-04-29
申请号：US12593269
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/52 , C07D473/00
CPC分类号： C07D473/04 , C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译： 本发明涉及新的嘌呤基衍生物及其作为钾通道调节剂的用途。 此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。
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69.发明申请PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开吡啶并吡唑衍生物及其作为钾通道调节剂的用途公开(公告)号：US20100035934A1
公开(公告)日：2010-02-11
申请号：US12525512
申请日：2008-02-01
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/4439 , C07D401/04 , A61P3/10 , A61P25/18 , A61P35/00
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译： 本发明涉及新的吡啶基 - 吡唑衍生物及其作为钾通道调节剂的用途。 此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。
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70.发明申请NOVEL 4-AMINO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开新型4-氨基吡啶衍生物及其作为钾通道调节剂的用途公开(公告)号：US20100035924A1
公开(公告)日：2010-02-11
申请号：US12514284
申请日：2007-11-13
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbæk , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/47 , C07D211/72 , A61K31/44 , C07D215/38
CPC分类号： C07D213/74 , C07D215/44
摘要： This invention relates to novel 4-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型4-氨基 - 吡啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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