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1.发明授权Diphenylurea derivatives and their use as chloride channel blockers or BKCa channel modulators 失效二苯基脲衍生物及其作为氯化物通道阻断剂或BKCa通道调节剂的用途公开(公告)号：US07985761B2
公开(公告)日：2011-07-26
申请号：US12280490
申请日：2007-03-09
IPC分类号： A61K31/4245 , C07D271/07
CPC分类号： C07D271/07
摘要： The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers or BKCa channel modulators.In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作氯化物通道阻断剂或BKCa通道调节剂的新型二苯基脲衍生物。 在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。
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2.发明申请NOVEL 1,4- AND 1,5-DIARYLSUBSTITUTED 1,2,3-TRIAZOLES USEFUL AS POTASSIUM CHANNEL MODULATORS 审中-公开新型1,4-和1,5-二磺基-1,2,3-三唑作为钾通道调节剂有用公开(公告)号：US20100105689A1
公开(公告)日：2010-04-29
申请号：US12523541
申请日：2008-01-17
申请人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/53 , C07D271/06 , A61K31/4245 , C07D257/04 , A61K31/41 , A61P11/00 , A61P25/00 , A61P9/00 , A61P3/00 , A61P35/00 , A61K31/496 , A61K31/4985
CPC分类号： C07D413/10 , C07D403/10
摘要： This invention relates to novel 1,4- and 1,5-diarylsubstituted 1,2,3-triazole derivatives that are found to be potent modulators of potassium channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of potassium channels.
摘要翻译： 本发明涉及被发现是钾通道的有效调节剂的新的1,4-和1,5-二芳基取代的1,2,3-三唑衍生物，因此它们是治疗疾病或病症的有价值的候选物， 与对钾通道调节有反应的那些不同。
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公开(公告)号：US20100137381A1
公开(公告)日：2010-06-03
申请号：US12598541
申请日：2008-04-29
申请人： Antonio Nardi , Morten Grunnet , Palle Christophersen , Joachim Demnitz , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Palle Christophersen , Joachim Demnitz , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/4245 , C07D257/04 , A61K31/41 , C07D271/06 , A61P3/10 , A61P9/10 , A61P9/00 , A61P9/06 , A61P35/00 , A61P25/06 , A61P25/16 , A61P25/28 , A61P25/22 , A61P25/24
CPC分类号： C07D257/04 , C07D271/07
摘要： This invention relates to novel acetamide derivatives that are found to be potent modulators of ion channels, in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及被发现是离子通道，特别是钾通道和氯化物通道的有效调节剂的新型乙酰胺衍生物，因此，作为治疗疾病或病症的有价值的候选物，其对于对 调节钾通道。
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公开(公告)号：US20100099732A1
公开(公告)日：2010-04-22
申请号：US12532264
申请日：2008-03-14
申请人： Antonio Nardi , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbaek , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbaek , Lars Siim Madsen
IPC分类号： A61K31/40
CPC分类号： A61K31/405 , C07D209/42
摘要： This invention relates to pharmaceutical compositions comprising phenylcarbamoyl-methyl-indole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及包含苯基氨基甲酰基 - 甲基 - 吲哚衍生物的药物组合物，其被发现是钾通道的有效调节剂，因此是用于治疗疾病或病症的有价值的候选物，其与对钾的调节有关 频道
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5.发明申请NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS 审中-公开作为离子通道调制器有用的新型的CINNAMIC AMIDE衍生物公开(公告)号：US20100087496A1
公开(公告)日：2010-04-08
申请号：US12519683
申请日：2007-12-17
申请人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Thomas Diness Jensen , Palle Christophersen , David Spencer Jones , Elsebet Ostergaard Nielsen , Dorte Strobaek , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Thomas Diness Jensen , Palle Christophersen , David Spencer Jones , Elsebet Ostergaard Nielsen , Dorte Strobaek , Lars Siim Madsen
IPC分类号： A61K31/165 , C07C233/01 , C07D257/04 , A61K31/41 , A61P15/00
CPC分类号： C07C309/15 , C07C1/26 , C07C17/10 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/46 , C07C311/51 , C07C2529/40 , C07C9/00 , C07C19/075
摘要： This invention relates to novel cinnamic amide derivatives that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of ion channels.
摘要翻译： 本发明涉及被认为是离子通道的有效调节剂的新型肉桂酰胺衍生物，因此，它们是用于治疗与对离子通道调节有反应的疾病或病症多种多样的有价值的候选物。
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6.发明申请ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS 审中-公开用于治疗神经阻滞性疾病的ARYL PIPERAZINE衍生物公开(公告)号：US20100087445A1
公开(公告)日：2010-04-08
申请号：US12445370
申请日：2007-10-12
申请人： Giuseppe Campiani , Stefania Butini , Caterina Fattorusso , Silvia Franceschini , Irene Zia Thale , Karin Sandager Nielsen , Jørgen Scheel-Krüeger , Lars Siim Madsen
发明人： Giuseppe Campiani , Stefania Butini , Caterina Fattorusso , Silvia Franceschini , Irene Zia Thale , Karin Sandager Nielsen , Jørgen Scheel-Krüeger , Lars Siim Madsen
IPC分类号： A61K31/496 , C07D401/12 , A61P25/00
CPC分类号： C07D215/48
摘要： This invention provides novel aryl piperazine derivatives represented by Formula (I) having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, 5HT1A and 5-HT2A receptor subtypes, and in particular useful for the treatment of neuropsychiatric disorders, incl. schizophrenia.
摘要翻译： 本发明提供具有医疗效用的式（I）表示的新型芳基哌嗪衍生物，特别是作为多巴胺和5-羟色胺受体的调节剂，优选D3,5HT1A和5-HT2A受体亚型，特别可用于治疗神经精神障碍， 包括 精神分裂症
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7.发明申请DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS OR BKCa CHANNEL MODULATORS 失效二氯乙烯衍生物及其作为氯离子通道阻滞剂或BKCa通道调节剂公开(公告)号：US20090018172A1
公开(公告)日：2009-01-15
申请号：US12280490
申请日：2007-03-09
IPC分类号： A61K31/4245 , C07D271/07 , A61P35/04 , A61P19/00
CPC分类号： C07D271/07
摘要： The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers or BKCa channel modulators.In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作氯化物通道阻断剂或BKCa通道调节剂的新型二苯基脲衍生物。 在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。
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8.发明授权Carbonylamino derivatives useful for the treatment of certain inflammatory disorders 有权用于治疗某些炎性疾病的羰基氨基衍生物公开(公告)号：US08455549B2
公开(公告)日：2013-06-04
申请号：US12674746
申请日：2008-08-21
IPC分类号： A61K31/165 , A61P1/04
CPC分类号： A61K31/165
摘要： The present invention relates to the use of a particular group of carbonylamino derivatives for the treatment or alleviation of a disease or condition relating to certain inflammatory disorders.
摘要翻译： 本发明涉及特定的一组羰基氨基衍生物用于治疗或减轻与某些炎性疾病有关的疾病或病症的用途。
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公开(公告)号：US20100137387A1
公开(公告)日：2010-06-03
申请号：US12598533
申请日：2008-04-29
申请人： Antonio Nardi , Jeppe Kejser Christensen , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Jeppe Kejser Christensen , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
CPC分类号： C07D257/04
摘要： This invention relates to novel β-keto-amide derivatives that are found to be potent modulators of ion channels, and in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及被发现是离子通道的有效调节剂，特别是钾通道和氯化物通道的新型的β-酮酰胺衍生物，因此，它们是用于治疗疾病或病症的有价值的候选物， 那些响应于钾通道调节的那些。
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10.发明申请NOVEL AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS 审中-公开新型芳香杂环羧酸酰胺衍生物作为钾通道调节剂有用公开(公告)号：US20100137312A1
公开(公告)日：2010-06-03
申请号：US12600159
申请日：2008-05-13
申请人： Antonio Nardi , Jeppe Kejser Christensen , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Jeppe Kejser Christensen , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/41 , C07D405/02 , C07D403/02 , C07D307/02 , C07D413/02 , C07D413/14 , A61K31/34 , A61K31/4245 , A61K31/454 , A61K31/5377 , A61P25/00 , A61P35/00 , A61P1/00 , A61P29/00
CPC分类号： C07D405/12 , C07D307/68 , C07D403/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention relates to novel aromatic heterocyclic carboxylic acid amide derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及式（I）的新型芳族杂环羧酸酰胺衍生物，其被发现是钾通道的有效调节剂，因此是用于治疗疾病或病症的有价值的候选物， 调节钾通道。
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