公开(公告)号：US06642397B1

公开(公告)日：2003-11-04

申请号：US09579163

申请日：2000-05-25

申请人： Michael John Reed ,  Barry Victor Lloyd Potter

发明人： Michael John Reed ,  Barry Victor Lloyd Potter

IPC分类号： C07J100

CPC分类号： A61K31/37 ,  C07D311/16 ,  C07D311/30 ,  C07D311/32 ,  C07D311/36 ,  C07J41/0072

摘要： A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring to which is attached sulphamate group of the formula wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alkylene optionally containing one or more hetero atoms or groups in the alkylene chain; and wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2); and if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37° C. it would provide a Km value of less than 50 &mgr;M.

摘要翻译： 描述了在需要相同的受试者中抑制类固醇硫酸酯酶活性的方法。 所述方法包括向所述受试者施用抑制甾族硫酸酯酶的量的环系化合物; 所述环系化合物包含连接在其上的环，其中R 1和R 2各自独立地选自H，烷基，烯基，环烷基和芳基，或一起表示任选地含有一个或多个杂原子或基团的亚烷基 亚烷基链; 并且其中所述化合物是具有类固醇硫酸酯酶活性的酶的抑制剂（E.C.3.1.6.2）; 并且如果所述化合物的氨基磺酸酯基团被硫酸根基团替代以形成硫酸盐化合物，并在pH 7.4和37℃下与类固醇硫酸酶（EC3.1.6.2）一起温育，则其将提供小于 50亩。

公开(公告)号：US06506792B1

公开(公告)日：2003-01-14

申请号：US09638315

申请日：2000-08-14

申请人： Michael John Reed ,  Barry Victor Lloyd Potter

发明人： Michael John Reed ,  Barry Victor Lloyd Potter

IPC分类号： A61K31352

CPC分类号： C07D311/30 ,  C07D311/32 ,  C07D311/36

摘要： The instant invention relates to sulphamate compounds of formula I, wherein A represents a ring structure, B represents a ring structure, D a ring structure, C is a bond, E is a link joining ring structure B to the ring structure D, X represents a suitable first group, and Y represents a suitable second group; wherein one ring of the compound is a phenolic ring; and wherein any one of ring structures A, B and D has a bound thereto a sulphamate group.

摘要翻译： 本发明涉及式I的氨基磺酸酯化合物，其中A表示环结构，B表示环结构，D表示环结构，C为键，E为环结构B与环结构D的连接，X表示 合适的第一组，Y表示合适的第二组; 其中所述化合物的一个环是酚醛环; 并且其中环结构A，B和D中的任何一个具有与其结合的氨基磺酸酯基团。

公开(公告)号：US06384193B1

公开(公告)日：2002-05-07

申请号：US09286896

申请日：1999-04-06

申请人： Michael John Reed ,  Anita Singh ,  Atul Purohit

发明人： Michael John Reed ,  Anita Singh ,  Atul Purohit

IPC分类号： C07A1400

CPC分类号： A61K31/138 ,  A61K38/1793 ,  A61K38/204 ,  A61K38/2073

摘要： A system comprising a IL-6-IL-6sR complex and an agent that can block the interaction of the complex with gp130 to regulate oestrogen synthesis.

摘要翻译： 一种包含IL-6-IL-6sR复合物和可阻断复合物与gp130相互作用以调节雌激素合成的试剂的系统。

公开(公告)号：US20190102850A1

公开(公告)日：2019-04-04

申请号：US15720305

申请日：2017-09-29

申请人： David McMakin Wheeler ,  Ned M. Smith ,  Thimas Barnes Abels ,  Michael John Reed ,  Clair Michael Bowman ,  Thomas John Barnes

发明人： David McMakin Wheeler ,  Ned M. Smith ,  Thimas Barnes Abels ,  Michael John Reed ,  Clair Michael Bowman ,  Thomas John Barnes

IPC分类号： G06Q50/18 ,  G06Q30/06 ,  G06Q20/12

摘要： Embodiments involve using smart contracts in a decentralized network as a framework for a smart city commodity exchange. In at least one embodiment, consumers and service providers negotiate terms and conditions of a smart contract for providing goods or services to the consumer. The service provider may provide all requested goods and services or bundle goods and services provided from multiple vendors. Verification of smart contract fulfillment may be assisted by information from sensors or other independent data collection. The service provider may provide discounted services in exchange for information to provide to a third party. Resources of both the consumer and service provide are committed during smart contract negotiations until completion of the smart contract, or rejection of the offered terms. Resource commitments, smart contract generation, performance of the smart contract and intermediate transactions are recorded in public ledgers according to Blockchain protocols. Other embodiments are described and claimed.

公开(公告)号：US06187766B1

公开(公告)日：2001-02-13

申请号：US09238345

申请日：1999-01-27

申请人： Michael John Reed ,  Barry Victor Potter

发明人： Michael John Reed ,  Barry Victor Potter

IPC分类号： A61K31165

CPC分类号： A61K31/37 ,  C07D311/16 ,  C07D311/30 ,  C07D311/32 ,  C07D311/36 ,  C07J41/0072

摘要： A method of inhibiting steroid sulphatase activity in a subject in need of same as described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring to which is attached a sulphamate group of the formula wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alkylene optionally containing one or more hetero atoms or groups in the alkylene chain; and wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2); and if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37° C. it would provide a Km value of less than 50 &mgr;M.

摘要翻译： 一种抑制需要与上述相同的对象的类固醇硫酸酯酶活性的方法。该方法包括向所述受试者施用抑制甾类硫酸酯酶的量的环系化合物; 所述环系化合物包含与R 1和R 2各自独立地选自H，烷基，烯基，环烷基和芳基的或者一起表示任选含有一个或多个杂原子或基团的亚烷基 亚烷基链; 并且其中所述化合物是具有类固醇硫酸酯酶活性的酶的抑制剂（E.C.3.1.6.2）; 并且如果所述化合物的氨基磺酸酯基团被硫酸根基团替代以形成硫酸盐化合物，并在pH 7.4和37℃下与类固醇硫酸酶（EC3.1.6.2）一起温育，则其将提供小于 50亩。

公开(公告)号：US07160860B2

公开(公告)日：2007-01-09

申请号：US10988628

申请日：2004-11-16

申请人： Michael John Reed

发明人： Michael John Reed

IPC分类号： A61K38/00

CPC分类号： A61K38/204

摘要： The invention described herein relates to the use of human interleukin-6 antagonists, totally incapable of binding to gp 130, as specific inhibitors of the enzyme aromatase, useful for the treatment of hormone-dependent tumours, and particularly tumours of the breast.

摘要翻译： 本文描述的本发明涉及完全不能结合gp 130的人白细胞介素-6拮抗剂作为芳香族酶的特异性抑制剂的用途，其可用于治疗激素依赖性肿瘤，特别是乳腺肿瘤。

公开(公告)号：US5691386A

公开(公告)日：1997-11-25

申请号：US633396

申请日：1996-04-16

申请人： Wayne D. Inman ,  Michael John Reed

发明人： Wayne D. Inman ,  Michael John Reed

IPC分类号： A61K31/155 ,  A61K31/425 ,  A61K31/64 ,  A61K31/715 ,  C07J63/00 ,  A61K31/12

CPC分类号： A61K31/7004 ,  A61K31/155 ,  A61K31/425 ,  A61K31/64 ,  A61K31/715 ,  C07J63/008

摘要： A novel hypoglycemically active triterpenoid compound isolated in purified, preferably substantially purified, form from Salacia spp., processes for obtaining the novel triterpenoid compound, compositions comprising the triterpenoid compound and methods for use a hypoglycemic agent, for example, in the treatment of diabetes, are described. In a preferred embodiment, the triterpenoid compound is obtained from Salacia prinoides. As an agent for the treatment of diabetes, the novel triterpenoid is useful for treating insulin-dependent (type I) and/or non-insulin-dependent (type II) diabetes.

摘要翻译： 从Salacia spp。纯化，优选基本上纯化的形式中分离的一种新型低血糖活性三萜化合物，获得新型三萜化合物的方法，包含三萜化合物的组合物和使用降血糖剂的方法，例如治疗糖尿病， 被描述。 在一个优选的实施方案中，三萜化合物是从Salacia prinoides获得的。 作为治疗糖尿病的药物，新型三萜类化合物可用于治疗胰岛素依赖型（I型）和/或非胰岛素依赖型（II型）糖尿病。