公开(公告)号：US06656216B1

公开(公告)日：2003-12-02

申请号：US09895753

申请日：2001-06-29

申请人： Syed F. A. Hossainy ,  Orlando Padilla ,  Daryush Mirzaee

发明人： Syed F. A. Hossainy ,  Orlando Padilla ,  Daryush Mirzaee

IPC分类号： A61F206

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/075 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2230/0076 ,  A61F2250/0018 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  Y10S623/916

摘要： A composite stent and methods for making the same are provided. In one embodiment a regioselective band is formed in situ on the stent. In one embodiment, the band is made of a regioselective material having a high creep compliance and having a second modulus of elasticity lower than that of a structural material comprising the stent. In one embodiment, the regioselective material is drip-coated or dip-coated on the stent near the ends. In one embodiment, the regioselective material includes a therapeutic agent, which may be a radioactive emitter, an anti-platelet drug, or an anti-proliferative drug.

摘要翻译： 提供复合支架及其制造方法。 在一个实施例中，在支架上原位形成区域选择性带。 在一个实施方案中，带由区域选择性材料制成，具有高蠕变柔量并且具有低于包含支架的结构材料的第二弹性模量。 在一个实施方案中，区域选择性材料在端部附近滴加或浸涂在支架上。 在一个实施方案中，区域选择性材料包括治疗剂，其可以是放射性发射体，抗血小板药物或抗增殖药物。

公开(公告)号：US5957903A

公开(公告)日：1999-09-28

申请号：US976444

申请日：1997-11-25

申请人： Daryush Mirzaee ,  William Stephen Tremulis

发明人： Daryush Mirzaee ,  William Stephen Tremulis

IPC分类号： A61B5/00 ,  A61B19/00 ,  A61M25/00 ,  A61M25/09

CPC分类号： A61M25/09 ,  A61M25/09033 ,  A61M2025/09083 ,  A61M2025/09091 ,  A61M2025/0915

摘要： Using a variable stiffness guidewire to cross a stenosed region of a patient's vasculature by advancing the distal end of the guidewire to the stenosed region, reducing the flexibility of the distal end of the guidewire, and further advancing the distal end through and past the stenosed region of the lumen. The variable stiffness guidewire has a longitudinally movable core member with a proximal end and a shapable distal end, a compressible body is slidably mounted on the core member, with one end of the compressible body secured to the end of the core member, and a tubular support member is disposed about the core member with a distal end that abuts the proximal end of the compressible body. The guidewire further comprises a tensioning means at the proximal end to move the core member longitudinally with respect to the tubular support member so as to compress and reduce the flexibility of the compressible body.

摘要翻译： 使用可变刚度导丝通过将导丝的远端推进到狭窄区域来横穿患者脉管系统的狭窄区域，降低导丝远端的柔韧性，并进一步使远端前进通过狭窄区域 的流明。 可变刚度导丝具有纵向可移动的芯构件，其具有近端和可成形的远端，可压缩主体可滑动地安装在芯构件上，可压缩主体的一端固定到芯构件的端部，并且管状 支撑构件围绕所述芯构件设置有远端，所述远端邻接所述可压缩体的近端。 导丝还包括在近端处的张紧装置，以相对于管状支撑构件纵向移动芯构件，以便压缩并降低可压缩体的柔性。