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162 条记录 (耗时 0.053 秒)

    Methods of preventing and reducing the severity of stress-associated conditions
    64.
    发明授权
    Methods of preventing and reducing the severity of stress-associated conditions 有权
    预防和减轻压力相关病症严重程度的方法

    公开(公告)号：US07977335B2

    公开(公告)日：2011-07-12

    申请号：US12114727

    申请日：2008-05-02

    申请人： Daniel W. Gil ,  Scott Whitcup ,  Mitchell F. Brin ,  John E. Donello

    发明人： Daniel W. Gil ,  Scott Whitcup ,  Mitchell F. Brin ,  John E. Donello

    IPC分类号： A61K31/198

    CPC分类号： A61K31/498

    摘要： The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatological conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

    摘要翻译： 本发明提供了通过向受试者全身施用有效量的溴莫尼定或其药学上可接受的盐，酯，酰胺，立体异构体或外消旋混合物来提供预防或减轻受试者的应激相关状况的严重性的方法。 可以根据本发明的方法治疗的应激相关病症包括但不限于消化不良，与心肌缺血相关的心动过速以外的心动过速，惊恐发作，非炎性皮肤病学条件，肌肉收缩障碍，感觉超敏反应 与偏头痛和行为障碍相关。

    Methods of Preventing and Reducing the Severity of Stress-Associated Conditions
    68.
    发明申请
    Methods of Preventing and Reducing the Severity of Stress-Associated Conditions 审中-公开
    预防和减少压力相关条件严重程度的方法

    公开(公告)号：US20120302574A1

    公开(公告)日：2012-11-29

    申请号：US13486847

    申请日：2012-06-01

    申请人： Daniel W. Gil ,  Scott Whitcup ,  Mitchell F. Brin ,  John E. Donello

    发明人： Daniel W. Gil ,  Scott Whitcup ,  Mitchell F. Brin ,  John E. Donello

    IPC分类号： A61K31/498 ,  A61P17/00 ,  A61P29/00

    CPC分类号： A61K31/498

    摘要： The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatogical conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

    摘要翻译： 本发明提供了通过向受试者全身施用有效量的溴莫尼定或其药学上可接受的盐，酯，酰胺，消旋异构体或外消旋混合物来提供预防或降低受试者中与应激相关的病症的严重程度的方法。 可以根据本发明的方法治疗的应激相关病症包括但不限于消化不良，与心肌缺血相关的心动过速以外的心动过速，惊恐发作，非炎性皮肤病症状，肌肉收缩障碍，感觉超敏反应 与偏头痛和行为障碍相关。