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公开(公告)号:US20060229323A1
公开(公告)日:2006-10-12
申请号:US11399790
申请日:2006-04-05
申请人: Alexander Alanine , Luca Gobbi , Sabine Kolczewski , Thomas Luebbers , Jens-Uwe Peters , Lucinda Steward
发明人: Alexander Alanine , Luca Gobbi , Sabine Kolczewski , Thomas Luebbers , Jens-Uwe Peters , Lucinda Steward
IPC分类号: A61K31/517 , C07D239/84
CPC分类号: C07D409/04 , C07D239/84 , C07D413/04
摘要: The present invention relates to compounds of formula wherein R1, R2, and n are as defined herein and to pharmaceutically acceptable acid addition salts thereof. The compounds of formula I have a good activity on the 5-HT5A receptor. Therefore, the invention provides the use of a compound of formula I for 5-HT5A receptor related diseases, such as anxiety, depression, sleep disorders and schizophrenia.
摘要翻译: 本发明涉及下式的化合物,其中R 1,R 2,和n如本文所定义,并且其药学上可接受的酸加成盐。 式I化合物对5-HT 5A 5A受体具有良好的活性。 因此,本发明提供式I化合物在5-HT 5A受体相关疾病如焦虑,抑郁,睡眠障碍和精神分裂症中的用途。
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公开(公告)号:US20050075327A1
公开(公告)日:2005-04-07
申请号:US10951229
申请日:2004-09-27
申请人: Alexander Flohr , Guido Galley , Roland Jakob-Roetne , Eric Kitas , Jens-Uwe Peters , Wolfgang Wostl
发明人: Alexander Flohr , Guido Galley , Roland Jakob-Roetne , Eric Kitas , Jens-Uwe Peters , Wolfgang Wostl
IPC分类号: C07D223/16 , C07D223/18 , C07D243/12 , C07D243/24 , C07D409/12 , A61K31/5513 , A61K31/55
CPC分类号: C07D409/12 , C07D223/16 , C07D223/18 , C07D243/12 , C07D243/24
摘要: The present invention provides compounds of the general formula wherein R4 is one of the following groups and R1, R2, R3, R7, R8, and R9 are as defined in the specification and pharmaceutically acceptable salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds are useful for the treatment of Alzheimer's disease.
摘要翻译: 本发明提供下列通式的化合物其中R 4是下列基团之一,R 1,R 2,R 3,R 7,R 8和R 9 >如本说明书和其药学上可接受的盐,光学纯对映异构体,外消旋物或非对映体混合物中所定义。 该化合物可用于治疗阿尔茨海默病。
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