公开(公告)号：US5674285A

公开(公告)日：1997-10-07

申请号：US570802

申请日：1995-12-12

Applicant: Joel Quaid

Inventor： Joel Quaid

IPC: A61F2/00 ,  A61F2/12 ,  A61L27/18 ,  A61L27/56 ,  C08J9/26

CPC classification number: C08J9/26 ,  A61F2/0077 ,  A61F2/12 ,  A61L27/18 ,  A61L27/56 ,  C08J2201/0446 ,  C08J2383/04

Abstract: A medical implant with an external surface layer of silicone elastomer and having an open-cell structure is made by applying solid particles to the external surface layer of the implant before it is cured, curing the external surface layer with the solid particles embedded therein and then dissolving the solid particles with a solvent that does not dissolve the silicone elastomer. An implant having such an external surface layer is expected to help prevent capsular contraction, to help prevent scar formation, and to help in anchoring the implant within the body.

Abstract translation: 具有硅氧烷弹性体外表面层并且具有开孔结构的医用植入物在其固化之前通过将固体颗粒施加到植入物的外表面层上来固化，固化外表面层，固体颗粒嵌入其中，然后 用不溶解硅氧烷弹性体的溶剂溶解固体颗粒。 期望具有这种外表面层的植入物有助于防止荚膜收缩，以帮助防止瘢痕形成，并帮助将植入物锚固在体内。

公开(公告)号：US5607695A

公开(公告)日：1997-03-04

申请号：US364080

申请日：1994-12-23

Applicant: Bo R. Ek ,  Kjell G. Eriksson ,  Per Gustaf H. Nyqvist ,  Gert A. Ragnarsson

Inventor： Bo R. Ek ,  Kjell G. Eriksson ,  Per Gustaf H. Nyqvist ,  Gert A. Ragnarsson

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/52 ,  A61K47/38 ,  C08B15/02 ,  C08J9/26 ,  C08L1/02 ,  A61K9/10

CPC classification number: C08J9/26 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2081 ,  C08B15/02 ,  C08L1/02 ,  C08J2201/0446 ,  C08J2301/02

Abstract: A process for the manufacture of porous cellulose particles, which have regular shape, and a capacity of sorbing 1.5-9 times of their own weight of water, a tap bulk density of less than 0.85 g/ml is provided. The process for the manufacture of these porous cellulose matrices is performed by mechanically treating of hydrolyzed cellulose in a wet stage. The cellulose matrices have preferably a size of at least 0.1 mm and a tap bulk density of 0.1-0.7 g/ml. A bioactive substance or bioactive substances could be sorbed, precipitated or sublimized into the porous structure of the matrices. The matrices can be admixed with drugs or drug containing granules in order to improve the tabletting and tablet properties and thereafter compressed.Drug loaded matrices can be used for direct compression of tablets.

Abstract translation: PCT No.PCT / SE91 / 00396 Sec。 371日期：1992年11月30日 102（e）1992年11月30日日期PCT 1991年6月5日PCT公布。 出版物WO91 / 18590 日期1991年12月12日制造具有规则形状的多孔纤维素颗粒的制造方法，以及吸收其自身重量的1.5-9倍的能力，小于0.85g / ml的水龙头堆积密度。 制造这些多孔纤维素基质的方法是通过在湿阶段中机械处理水解纤维素进行的。 纤维素基质优选具有至少0.1mm的尺寸和0.1-0.7g / ml的堆积密度。 可以将生物活性物质或生物活性物质吸附，沉淀或升华成基质的多孔结构。 这些基质可以与药物或含药物的颗粒混合，以改善压片和片剂性质，然后压缩。 药物负载基质可用于直接压片。

公开(公告)号：US5007929A

公开(公告)日：1991-04-16

申请号：US559973

申请日：1990-07-27

Applicant: Joel Quaid

Inventor： Joel Quaid

IPC: A61F2/00 ,  A61F2/12 ,  A61L27/18 ,  A61L27/56 ,  C08J9/26

CPC classification number: C08J9/26 ,  A61F2/0077 ,  A61F2/12 ,  A61L27/18 ,  A61L27/56 ,  B29C41/14 ,  B29C59/02 ,  B29C2059/028 ,  C08J2201/0446 ,  C08J2383/04

Abstract: A medical implant with an external surface layer of silicone elastomer and having an open-cell structure is made by applying solid particles to the external surface layer of the implant before it is cured, curing the external surface layer with the solid particles embedded therein and then dissolving the solid particles with a solvent that does not dissolve the silicone elastomer. An implant having such an external surface layer is expected to help prevent capsular contraction, to help prevent scar formation, and to help in anchoring the implant within the body.

Abstract translation: 具有硅氧烷弹性体外表面层并且具有开孔结构的医用植入物在其固化之前通过将固体颗粒施加到植入物的外表面层上来固化，固化外表面层，固体颗粒嵌入其中，然后 用不溶解硅氧烷弹性体的溶剂溶解固体颗粒。 期望具有这种外表面层的植入物有助于防止荚膜收缩，以帮助防止瘢痕形成，并帮助将植入物锚固在体内。

公开(公告)号：US3556161A

公开(公告)日：1971-01-19

申请号：US3556161D

申请日：1965-08-30

Applicant: DU PONT

Inventor： ROBERTS ROBERT

IPC: B29C67/20 ,  C08J5/18 ,  C08J9/26 ,  C08J9/28 ,  H01M2/16 ,  B29D27/00 ,  F16L9/12

CPC classification number: C08J5/18 ,  B29C67/202 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0446 ,  C08J2201/0502 ,  C08J2327/18 ,  H01M2/1646 ,  H01M2/1653 ,  Y10T428/249953 ,  Y10T428/24998 ,  Y10T428/29

Abstract: A sheet comprising per 100 parts by volume 0-39 parts liquid capable of wetting polytetrafluoroethylene and 61-100 parts complementally of solid material comprising 5-100 volume percent polytetrafluoroethylene resin and 0-95 volume percent complementally of particulate solid filler, said sheet having a volume shrinkage of less than 39 percent on drying and heattreating, further characterized in that the polytetrafluoroethylene resin is present substantially entirely in the form of discrete lamellae less than 10 microns thick, which lamellae are molecularly oriented parallel to the faces of said structure and have a molecular orientation as determined by an A X-ray ratio of from 1 to 0.4 and a B X-ray ratio of from 0.7 to 0.05.