公开(公告)号：US4049651A

公开(公告)日：1977-09-20

申请号：US678001

申请日：1976-04-19

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D501/36

CPC classification number: C07D501/36

Abstract: Alkoxy and alkylthioalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is lower alkyl; Y is O or S; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are disclosed. These compounds are useful as antibacterial agents.

Abstract translation: 其中R为氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，成盐离子或基团R1的烷氧基和烷硫基烷基脲基头孢菌素 氢或甲氧基; A是1至6个碳的直链或支链亚烷基; R2是低级烷基; Y为O或S; R3是氢或低级烷基; R4是氢，低级烷基，环烷基，环烯基，环链二烯基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基或某些杂环基; R5是氢或低级烷基; R6是低级烷基; X是氢，低级烷酰氧基，或者某些杂硫基; 被披露。 这些化合物可用作抗菌剂。

公开(公告)号：US4033958A

公开(公告)日：1977-07-05

申请号：US715600

申请日：1976-08-18

Applicant: Uwe D. Treuner

Inventor： Uwe D. Treuner

IPC: C07D231/14 ,  C07D487/04

CPC classification number: C07D231/14

Abstract: New 4-amino derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##STR1## R.sub.1 is hydrogen, lower alkyl or a salt forming ion; R.sub.2 and R.sub.3 each is hydrogen, lower alkyl, cyclo-lower alkyl, phenyl, substituted phenyl, phenyl-lower alkylene, di-lower alkylamino-lower alkylene or R.sub.2 and R.sub.3 together with the nitrogen form an unsubstituted or substituted 5- or 6-membered nitrogen heterocyclic in which an additional nitrogen or oxygen may be present.R.sub.4 is hydrogen, lower alkyl or halogen.The new compounds are useful as anti-inflammatory agents.

Abstract translation: 吡唑并[1,5-a]喹喔啉-3-羧酸的新4-氨基衍生物，酯及其盐具有下式：R1是氢，低级烷基或成盐离子; R 2和R 3各自为氢，低级烷基，环低级烷基，苯基，取代的苯基，苯基 - 低级亚烷基，二低级烷基氨基 - 低级亚烷基，或者R 2和R 3与氮一起形成未取代或取代的5-或6- 其中可能存在另外的氮或氧。

公开(公告)号：US3996218A

公开(公告)日：1976-12-07

申请号：US611041

申请日：1975-09-08

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/36 ,  C07D501/24

CPC classification number: C07D333/24

Abstract: Ureido cephalosporin derivatives of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl or phenyl-lower alkyl, or certain heterocyclic groups; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or methoxy; R.sub.4 is hydrogen, halogen, lower alkyl, or lower alkoxy; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl, phenyl, or phenyl-lower alkyl; are disclosed. These compounds are useful as antibacterial agents.

Abstract translation: 其中R为氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，成盐离子或基团R 1为氢原子的脲基头孢菌素衍生物 ，低级烷基，环烷基，环烯基，环烷二烯基，苯基，苯基 - 低级烷基，取代的苯基或苯基 - 低级烷基，或某些杂环基; R2是氢或低级烷基; R3是氢或甲氧基; R4是氢，卤素，低级烷基或低级烷氧基; R5是氢或低级烷基; R6是低级烷基，苯基或苯基 - 低级烷基; 被披露。 这些化合物可用作抗菌剂。

公开(公告)号：US3996216A

公开(公告)日：1976-12-07

申请号：US581443

申请日：1975-05-28

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/57 ,  C07D501/24 ,  C07D501/22 ,  C07D501/36

CPC classification number: C07D333/24

Abstract: 3-Heterothio(formylamino)acetylamino cephalosporin derivatives of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl, furyl, pyridyl or thienyl; R.sub.2 is a five or six membered nitrogen, sulfur and/or oxygen containing heterocyclic ring system; R.sub.3 is lower alkyl, phenyl or phenyl-lower alkyl; and R.sub.4 is hydrogen or lower alkyl; are useful antibacterial agents.

Abstract translation: 其中R是氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤乙基，成盐离子或基团R 1的3-异硫代（甲酰氨基）乙酰氨基头孢菌素衍生物 氢，低级烷基，环低级烷基，不饱和环低级烷基，苯基，取代的苯基，呋喃基，吡啶基或噻吩基; R2是五或六元氮，硫和/或含氧杂环系统; R3是低级烷基，苯基或苯基 - 低级烷基; R4为氢或低级烷基; 是有用的抗菌剂。

公开(公告)号：US3994889A

公开(公告)日：1976-11-30

申请号：US581441

申请日：1975-05-28

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/57 ,  C07D501/24 ,  C07D501/22 ,  C07D501/36

CPC classification number: C07D333/24

Abstract: 3-Heterothio(.alpha.-thiocarbonylamino)-7.alpha.-methoxycephalosporin derivatives of the general formula ##SPC1##Wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##EQU1## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system, and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract translation: 3-异硫代（α-硫代羰基氨基）-7α-甲氧基头孢菌素衍生物，其通式为+ q，10，其中R为氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，成盐离子或 基团R5O |平行-CH-OC-R4; R 1是氢，低级烷基，环低级烷基，不饱和环低级烷基，苯基，取代的苯基或噻吩基; R2和R5各自为氢或低级烷基; R3是五或六元氮，硫和/或含氧环系，R4是低级烷基，苯基或苯基 - 低级烷基; 作为抗菌剂是有用的。

公开(公告)号：US3962229A

公开(公告)日：1976-06-08

申请号：US581449

申请日：1975-05-28

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D501/20 ,  C07D501/57

CPC classification number: C07D501/57

Abstract: New 2-(thiocarbonylamino)acetamido-7.alpha.-methoxy cephalosporanic acid compounds of the following general formula, and their salts, ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(halo)lower alkyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl, furyl, thienyl or pyridyl; R.sub.2 and R.sub.4 each is hydrogen or lower alkyl; R.sub.3 is lower alkyl, phenyl or phenyl-lower alkyl; and X is hydrogen, lower alkanoyloxy or azido; are useful as antibacterial agents.

公开(公告)号：US3950330A

公开(公告)日：1976-04-13

申请号：US533900

申请日：1974-12-18

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07D501/20 ,  C07D501/36

CPC classification number: C07C329/00

Abstract: 3-Alkylthio- and 3-heterothio derivatives of [[(thioalkoxy)thiocarbonyl]oxyl]acetylcephalosporins having the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, pyridyl, thienyl or furyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is lower alkyl, a five-membered heterocycle containing only nitrogen and carbon or nitrogen, carbon and oxygen or sulfur in the ring or pyridine-N-oxide; R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.