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    4-Halo derivatives of pyrazolo[1,5-a]-quinoxaline-3-carboxylic acids and esters
    5.
    发明授权
    4-Halo derivatives of pyrazolo[1,5-a]-quinoxaline-3-carboxylic acids and esters 失效
    吡唑并[8,1-a {9-喹喔啉-3-羧酸和酯的4-卤素衍生物

    公开(公告)号：US4128716A

    公开(公告)日：1978-12-05

    申请号：US833104

    申请日：1977-09-13

    Applicant: Uwe D. Treuner

    Inventor： Uwe D. Treuner

    IPC: C07D231/14 ,  C07D487/04 ,  A61K31/495

    CPC classification number: C07D487/04 ,  C07D231/14

    Abstract: New 4-halo derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##STR1## R.sub.1 is hydrogen, lower alkyl or a salt forming ion; R.sub.2 is hydrogen, lower alkyl, halogen or lower alkoxy; and X is halogen.The new compounds are useful as intermediates and as anti-inflammatory agents.

    Abstract translation: 吡唑并[1,5-a]喹喔啉-3-羧酸的新4-卤代衍生物，酯及其盐具有下式：R1是氢，低级烷基或成盐离子; R2是氢，低级烷基，卤素或低级烷氧基; X为卤素。

    3-HETEROTHIOMETHYL UREIDO CEPHALOSPORINS
    6.
    发明授权
    3-HETEROTHIOMETHYL UREIDO CEPHALOSPORINS 失效
    3-HETEROTHOMETHYL UREIDO CEPHALOSPORINS

    公开(公告)号：US4127716A

    公开(公告)日：1978-11-28

    申请号：US764134

    申请日：1977-02-02

    Applicant: Hermann Breuer ,  Uwe D. Treuner

    Inventor： Hermann Breuer ,  Uwe D. Treuner

    IPC: C07D307/54 ,  C07D333/24 ,  C07D501/36 ,  C07D501/56 ,  A61K31/545 ,  C07D501/54

    CPC classification number: C07D333/24 ,  C07D307/54

    Abstract: L-Isomer compounds of the formula ##STR1## wherein R.sub.1 is phenyl, thienyl or furyl; R.sub.4 represents certain heterocyclic groups; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion, or the group ##STR2## wherein R is lower alkyl, phenyl, phenyl-lower alkyl, or substituted phenyl and phenyl-lower alkyl are disclosed. These compounds are useful as antibacterial agents.

    Abstract translation: 其中R1是苯基，噻吩基或呋喃基的式（Ⅰ）的L-异构体化合物; R4表示某些杂环基; R3是氢，低级烷基，苯基 - 低级烷基，取代的苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲锡烷基，三（低级烷基）甲硅烷基，成盐离子或基团，其中R 是低级烷基，苯基，苯基 - 低级烷基或取代的苯基和苯基 - 低级烷基。 这些化合物可用作抗菌剂。

    3-(Carbamoyl)pyridino derivatives of 7a-methoxy ureidocephalosporins
    7.
    发明授权
    3-(Carbamoyl)pyridino derivatives of 7a-methoxy ureidocephalosporins 失效
    7-甲氧基脲基头孢菌素的3-（氨基甲酰基）吡啶衍生物

    公开(公告)号：US4100345A

    公开(公告)日：1978-07-11

    申请号：US761914

    申请日：1977-01-24

    Applicant: Hermann Breuer ,  Uwe D. Treuner

    Inventor： Hermann Breuer ,  Uwe D. Treuner

    IPC: C07D333/24 ,  C07D501/38 ,  C07D501/44 ,  C07D501/40

    CPC classification number: C07D333/24

    Abstract: Ureido cephalosporin derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl; or certain heterocyclic groups; are disclosed. These compounds are useful as antibacterial agents.

    Abstract translation: 其中R1是氢或甲氧基的式“IMAGE”的脲基头孢菌素衍生物; R2是氢或低级烷基; R3是氢，低级烷基，环烷基，环烯基，环链二烯基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基; 或某些杂环基团; 被披露。 这些化合物可用作抗菌剂。

    [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives
    8.
    发明授权
    [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives 失效
    {8 {8（2,4-二氧代-1-咪唑啉基）氨基{9羰基{9氨基{9-乙酰头孢菌素衍生物

    公开(公告)号：US4093801A

    公开(公告)日：1978-06-06

    申请号：US819648

    申请日：1977-07-27

    Applicant: Hermann Breuer ,  Uwe D. Treuner

    Inventor： Hermann Breuer ,  Uwe D. Treuner

    IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D233/80 ,  C07D333/24 ,  C07D501/20 ,  C07D501/36 ,  C07D501/34 ,  C07D501/46

    CPC classification number: C07D333/24 ,  C07D233/80

    Abstract: [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives having the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; R.sub.2, R.sub.3 and R.sub.5 each is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cyclo-lower alkyl, cyclo-lower alkenyl, cyclo-lower alkadienyl, phenyl, phenyl-lower alkyl, substitutted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are useful as antibacterial agents.

    Abstract translation: 具有下式的[[[（2,4-二氧代-1-咪唑烷基）氨基]羰基]氨基] - 乙酰头孢菌素衍生物其中R是氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基，三（低级） 烷基）甲硅烷基，三卤代乙基，成盐离子，或基团R 1是氢或甲氧基; R2，R3和R5各自为氢或低级烷基; R4是氢，低级烷基，环低级烷基，环低级烯基，环低级亚烷基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基或某些杂环基; R6是低级烷基; X是氢，低级烷酰氧基，或者某些杂硫基; 作为抗菌剂是有用的。

    3-Heterothio-7-ureido cephalosporins
    9.
    发明授权
    3-Heterothio-7-ureido cephalosporins 失效
    3-异硫脲-7-脲基头孢菌素

    公开(公告)号：US4088815A

    公开(公告)日：1978-05-09

    申请号：US664795

    申请日：1976-03-08

    Applicant: Hermann Breuer ,  Uwe D. Treuner

    Inventor： Hermann Breuer ,  Uwe D. Treuner

    IPC: C07D213/55 ,  C07D333/24 ,  C07D501/36

    CPC classification number: C07D333/24 ,  C07D213/55

    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl and substituted phenyl and phenyl-lower alkyl; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion, or the group ##STR2## wherein R is lower alkyl, phenyl, phenyl-lower alkyl, or substituted phenyl and phenyl-lower alkyl; and R.sub.4 represents certain heterocyclic groups are disclosed. These compounds are useful as antibacterial agents.

    Abstract translation: 其中R 1是氢，低级烷基，环烷基，环烯基，环烷二烯基，苯基，苯基 - 低级烷基和取代的苯基和苯基 - 低级烷基; R2是氢或低级烷基; R3是氢，低级烷基，苯基 - 低级烷基，取代的苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲锡烷基，三（低级烷基）甲硅烷基，成盐离子或基团，其中R 是低级烷基，苯基，苯基 - 低级烷基或取代的苯基和苯基 - 低级烷基; 并且R4表示某些杂环基。 这些化合物可用作抗菌剂。

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