公开(公告)号：US20230017301A1

公开(公告)日：2023-01-19

申请号：US17935891

申请日：2022-09-27

Applicant: Edwards Lifesciences Corporation

Inventor： Elena Sherman ,  Michael Bukin ,  Sandip Vasant Pawar ,  Shahram Zamani ,  Tamir S. Levi ,  Noam Nir ,  Yana Mayatskaya ,  Alexander Barash ,  Ziv Yohanan ,  Nikolay Gurovich ,  Itai Pelled

IPC: A61F2/24

Abstract: An implantable prosthetic device can include a frame movable between a radially compressed and a radially expanded configuration and a sealing member. The frame can include an inflow end portion, an outflow end portion, and a plurality of struts. The sealing member can be disposed around the frame and can include a cushioning layer comprising a plurality of texturized yarns extending along the longitudinal axis of the frame, and a base layer disposed between the cushioning layer and the frame.

公开(公告)号：US20220409368A1

公开(公告)日：2022-12-29

申请号：US17901662

申请日：2022-09-01

Applicant: Edwards Lifesciences Corporation

Inventor： Elena Sherman ,  Noam Nir

IPC: A61F2/24

Abstract: An assembly and associated method for a commissure of a prosthetic heart valve is disclosed. As one example, a method includes forming a plurality of commissures with the plurality of leaflets, wherein each commissure is formed by pairing a first commissure tab of a first leaflet with an adjacent, second commissure tab of a second leaflet, and coupling a support strip to the first and second commissure tabs via sutures forming stitches along the support strip, and, for each commissure, securing the commissure to a respective support of a frame by forming one or more suture loops around an external surface of the support strip and the respective support of the frame, the suture loops being formed by end portion extensions of the sutures.

公开(公告)号：US20220370198A1

公开(公告)日：2022-11-24

申请号：US17881042

申请日：2022-08-04

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Elena Sherman ,  Michael Bukin ,  Tamir S. Levi ,  Ziv Yohanan ,  David Maimon

IPC: A61F2/24

Abstract: An assembly and associated method for a commissure of a prosthetic heart valve is disclosed. As one example, a method includes forming a plurality of commissures with a plurality of leaflets of a prosthetic heart valve, wherein each commissure is formed by: folding each commissure tab of each leaflet into a series of overlapping layers, each folded commissure tab arranged outward of, in a lateral direction, a portion of a body of the leaflet that is directly connected to the commissure tab; pairing each folded commissure tab of each leaflet with a folded commissure tab of another leaflet; and securing at least a portion of the series of overlapping layers of each folded commissure tab in its folded configuration.

公开(公告)号：US20220323210A1

公开(公告)日：2022-10-13

申请号：US17851328

申请日：2022-06-28

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Elena Sherman ,  Tamir S. Levi ,  Michael Bukin

IPC: A61F2/24 ,  B29C65/62 ,  B29C65/00

Abstract: Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.

公开(公告)号：US20220008196A1

公开(公告)日：2022-01-13

申请号：US17486361

申请日：2021-09-27

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolay Gurovich ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

公开(公告)号：US11207175B2

公开(公告)日：2021-12-28

申请号：US16525439

申请日：2019-07-29

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolay Gurovich ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

公开(公告)号：US11129710B2

公开(公告)日：2021-09-28

申请号：US17088919

申请日：2020-11-04

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolay Gurovich ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

公开(公告)号：US11096781B2

公开(公告)日：2021-08-24

申请号：US15664430

申请日：2017-07-31

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey M. Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24

Abstract: A prosthetic heart valve can include a radially collapsible and expandable annular frame having a plurality of struts defining openings. The prosthetic heart valve can further include a plurality of leaflets that regulate the flow of blood through the frame. The prosthetic heart valve can also include a sealing member mounted on the frame and having an inner layer and an outer layer. At least the outer layer is mounted on the outside of the frame, and the inner layer covers at least the openings in the frame between adjacent cusp portions of adjacent leaflets and the inner layer does not cover one or more openings in the frame at locations facing the outflow surfaces of the leaflets to permit retrograde blood to flow through the one or more uncovered openings in the frame and into space between the outer layer and the frame.

公开(公告)号：US10849741B2

公开(公告)日：2020-12-01

申请号：US16601414

申请日：2019-10-14

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US20200205964A1

公开(公告)日：2020-07-02

申请号：US16799741

申请日：2020-02-24

Applicant: Edwards Lifesciences Corporation

Inventor： Tomer Saar ,  Michael Bukin ,  Elena Sherman ,  Alexander Barash ,  Yana Mayatskaya

IPC: A61F2/24

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, and a skirt member secured to the frame. The skirt member includes a plurality of extension portions wrapped around at least one strut member adjacent the extension portions. The prosthetic valve further includes a cord member threaded through at least a portion of the plurality of extension portions to secure the skirt member to the at least one strut member.