-
公开(公告)号:US07678369B2
公开(公告)日:2010-03-16
申请号:US11102576
申请日:2005-04-07
IPC分类号: A61K31/74
CPC分类号: A61K31/74 , A61K31/795 , A61K38/14 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00 , A61K31/415
摘要: The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
摘要翻译: 本发明涉及一种通过向动物施用治疗有效量的具有多个直接连接到聚合物主链或附着的侧链酸官能团的聚合物来抑制动物如人的毒素的方法 通过间隔基团与聚合物主链结合。 间隔基可以具有在0至约20个原子范围内的长度。 毒素通常是由病原微生物如细菌分泌的外毒素。
-
公开(公告)号:US20070256347A1
公开(公告)日:2007-11-08
申请号:US11381340
申请日:2006-05-02
IPC分类号: F41A35/04
摘要: The present invention is a modular handgrip for rifles and other long guns. The handgrip features a base with a locking dovetail rail on a first side and a second opposite side configured to receive a rail. Back strap additions are provided capable of receiving the rail on the body, which are customizable to a user's preferences while fore straps are provided with rails in a similar manner. Also provided is a storage compartment inside the main body, accessible from a bottom of the grip. As such, an organization, such as an armory, can provide a number of customizable options for handgrips while only stocking a basic grip and a number of optional modules at lower unit and storage costs.
摘要翻译: 本发明是用于步枪和其他长枪的模块化手柄。 手柄具有在第一侧上具有锁定燕尾轨的基座,以及配置成接收轨道的第二相对侧。 提供背带附加物,其能够接收身体上的轨道,其可以根据用户的偏好进行定制,而前带以类似的方式设置有轨道。 还设置有在主体内部的存储隔间,可从手柄的底部进入。 因此,诸如军械库的组织可以为手握提供多种可定制的选项,同时仅以更低的单位和存储成本存储基本抓地力和多个可选模块。
-
公开(公告)号:US20070025954A1
公开(公告)日:2007-02-01
申请号:US11454142
申请日:2006-06-15
IPC分类号: A61K31/785 , C08G73/02
CPC分类号: C08G73/0627 , A61K31/74 , A61K31/785 , A61K31/787 , A61K31/80 , C08G61/12 , C08G73/00 , C08G73/0226
摘要: Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.
摘要翻译: 公开了具有抗微生物活性的紫罗烯聚合物。 本发明中使用的“紫罗烯聚合物”是阳离子聚合物,其中提供正电荷的大部分原子是位于聚合物的主要聚合物链或骨架中而不是侧基的季铵化氮。 还公开了包含紫罗烯聚合物和用于治疗哺乳动物微生物感染的方法的抗微生物组合物,其包括向哺乳动物施用治疗有效量的本发明的至少一种抗微生物组合物的步骤。 还公开了包含至少一种紫罗烯聚合物的抗微生物组合物和用于预防,抑制或消除微生物在易感表面上的生长,扩散和/或积累的方法(包括但不限于在易感的表面上形成生物膜 包括使这种表面与本发明的组合物接触的步骤。
-
公开(公告)号:US06692732B2
公开(公告)日:2004-02-17
申请号:US10324623
申请日:2002-12-19
申请人: Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
发明人: Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
IPC分类号: A61K3174
CPC分类号: A61K31/785 , Y02A50/465 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要: A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译: 一种用于治疗哺乳动物(例如人)中致病性毒素的方法,包括用治疗有效量的包含连接到聚合物主链上的阳离子基团的聚合物来治疗哺乳动物。 聚合物可以是均聚物或共聚物。 在一个实施方案中,聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。
-
公开(公告)号:US06290947B1
公开(公告)日:2001-09-18
申请号:US09597343
申请日:2000-06-19
申请人: Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
发明人: Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
IPC分类号: A61K3174
CPC分类号: A61K31/785 , Y02A50/465 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要: A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译: 一种用于治疗哺乳动物(例如人)中致病性毒素的方法,包括用治疗有效量的包含连接到聚合物主链上的阳离子基团的聚合物来治疗哺乳动物。 聚合物可以是均聚物或共聚物。 在一个实施方案中,聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。
-
-
-
-