公开(公告)号：US20190201422A1

公开(公告)日：2019-07-04

申请号：US16330502

申请日：2017-09-14

申请人： UNION therapeutics A/S

发明人： Morten Otto Alexander Sommer ,  Rasmus Toft-Kehler

IPC分类号： A61K31/655 ,  A61K31/65 ,  A61K31/155 ,  A61K9/00

CPC分类号： A61K31/655 ,  A61K9/0014 ,  A61K9/007 ,  A61K31/155 ,  A61K31/65 ,  A61P31/04 ,  Y02A50/401 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/483 ,  A61K2300/00

摘要： This invention relates to combination products comprising an amidine selected from dibromopropamidine and diminazene or a pharmaceutically acceptable salt or solvate thereof; and a tetracycline anti-bacterial agent. The combination products are suitable for use in the treatment of bacterial infections or diseases.

公开(公告)号：US20190185860A1

公开(公告)日：2019-06-20

申请号：US16324955

申请日：2017-08-14

申请人： TOOLGEN INCORPORATED

发明人： Seok Joong KIM ,  Yoon-Young KIM ,  Ho-Sung YU ,  In-Young JUNG ,  Jung Min LEE

IPC分类号： C12N15/113 ,  C12N15/85 ,  C12N5/0784 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/52

CPC分类号： C12N15/1132 ,  A61K35/14 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/064 ,  C12N5/0646 ,  C12N9/22 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  Y02A50/47

摘要： The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.

公开(公告)号：US20180271778A1

公开(公告)日：2018-09-27

申请号：US15979918

申请日：2018-05-15

申请人： Patricia Guerry ,  Mario Artur Monteiro

发明人： Patricia Guerry ,  Mario Artur Monteiro

IPC分类号： A61K9/00 ,  A61K31/715

CPC分类号： A61K9/0019 ,  A61K31/715 ,  A61K39/105 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/6037 ,  Y02A50/47

摘要： The inventive subject matter relates to an immunogenic composition against Campylobacter jejuni comprising isolated capsule polysaccharide from selected pathogenic Campylobacter jejuni strains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing an anti-C. jejuni immune response.

公开(公告)号：US20180207183A1

公开(公告)日：2018-07-26

申请号：US15935862

申请日：2018-03-26

申请人： Rempex Pharmaceuticals, Inc.

发明人： Gavin Hirst ,  Raja Reddy ,  Scott Hecker ,  Maxim Totrov ,  David C. Griffith ,  Olga Rodny ,  Michael N. Dudley ,  Serge Boyer

IPC分类号： A61K31/69 ,  C07F5/02 ,  A61K45/06 ,  A61K31/546 ,  A61K31/4439 ,  A61K9/00 ,  A61K31/4196 ,  A61K31/407 ,  A61K31/427

CPC分类号： A61K31/69 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/546 ,  A61K45/06 ,  C07F5/025 ,  Y02A50/401 ,  Y02A50/406 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/483 ,  A61K2300/00

摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

公开(公告)号：US09987338B2

公开(公告)日：2018-06-05

申请号：US15400707

申请日：2017-01-06

申请人： The MITRE Corporation

发明人： Michael Heath Farris

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61K9/06 ,  C12N9/52 ,  A01N37/46 ,  A23L2/52 ,  A23L33/10

CPC分类号： A61K38/48 ,  A01N37/46 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/06 ,  C07K14/36 ,  C07K2319/00 ,  C12N9/52 ,  C12Q1/04 ,  C12Q1/10 ,  C12Q1/18 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56938 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/52

摘要： The present invention provides a Mitrecin A polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a Mitrecin A polypeptide. The target bacteria can be selected from the group consisting of a Gram-positive bacterium, a Gram-negative bacterium, or both. In one embodiment, the present invention is drawn to a polynucleotide encoding a Mitrecin A polypeptide, a vector comprising the polynucleotide, a host cell comprising the polynucleotide, or a composition comprising the Mitrecin A polypeptide, the polynucleotide, the vector, or the host cell.

公开(公告)号：US20180028449A1

公开(公告)日：2018-02-01

申请号：US15635169

申请日：2017-06-27

申请人： Ansun Biopharma, Inc.

发明人： Michael P. Malakhov ,  Fang Fang

IPC分类号： A61K9/16 ,  A61K9/19 ,  A61K9/50 ,  A61K31/198 ,  A61K31/337 ,  C12N15/113 ,  C12N9/96 ,  C12N7/00 ,  C07K14/765 ,  C07K9/00 ,  C07D305/14 ,  A61K38/48 ,  A61K38/47 ,  A61K38/46 ,  A61K38/42 ,  A61K38/38 ,  A61K38/18 ,  A61K38/17 ,  A61K38/16 ,  A61K38/14 ,  A61K38/12 ,  A61K38/08 ,  A61K35/76 ,  A61K31/724 ,  A61K31/721 ,  A61K31/7036 ,  A61K31/65 ,  A61K31/5575 ,  A61K31/557 ,  A61K31/555 ,  A61K31/43 ,  A61K31/405 ,  A61K31/343 ,  A61K9/00

CPC分类号： A61K9/1682 ,  A61K9/0048 ,  A61K9/0075 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/19 ,  A61K9/5089 ,  A61K31/198 ,  A61K31/337 ,  A61K31/343 ,  A61K31/405 ,  A61K31/43 ,  A61K31/555 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/721 ,  A61K31/724 ,  A61K35/76 ,  A61K38/08 ,  A61K38/12 ,  A61K38/14 ,  A61K38/168 ,  A61K38/1709 ,  A61K38/1808 ,  A61K38/38 ,  A61K38/385 ,  A61K38/42 ,  A61K38/465 ,  A61K38/47 ,  A61K38/4826 ,  C07D305/14 ,  C07K9/008 ,  C07K14/765 ,  C12N7/00 ,  C12N9/96 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/50 ,  C12N2330/30 ,  C12N2770/00021 ,  C12N2770/00051 ,  C12Y301/21001 ,  C12Y301/27005 ,  C12Y302/00 ,  C12Y302/01017 ,  C12Y302/01018 ,  C12Y304/21004 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/411 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483 ,  Y02A50/49 ,  Y02A50/491

摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

公开(公告)号：US09849099B2

公开(公告)日：2017-12-26

申请号：US15233450

申请日：2016-08-10

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： Douglas Benjamin Weibel ,  Katherine Ann Hurley ,  Katherine Cassidy Faulkner

IPC分类号： A61K31/137 ,  A01N33/10 ,  C07D209/16 ,  A61K31/4045 ,  A01N43/38

CPC分类号： A61K31/137 ,  A01N33/10 ,  A01N43/38 ,  A61K31/4045 ,  C07D209/16 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  A01N2300/00

摘要： Described herein are antimicrobial compounds identified via a high-throughput screen to identify compounds that produce anucleate cells in E. coli after cell division occurs. Compound 1 (5-nonyloxytryptamine) and its analogs are small molecule inhibitors of the nucleoid occlusion system and/or proteins that are responsible for maintaining the structure of the chromosome. The antimicrobial compounds are useful to treat bacterial infections as well as to inhibit bacterial growth.

公开(公告)号：US20170360881A1

公开(公告)日：2017-12-21

申请号：US15625672

申请日：2017-06-16

申请人： Aileron Therapeutics, Inc.

发明人： Manoj Samant ,  Krzysztof Darlak ,  Eric Feyfant ,  Steve DeMarco

IPC分类号： A61K38/12 ,  A61K45/06

CPC分类号： A61K38/12 ,  A61K45/06 ,  Y02A50/385 ,  Y02A50/397 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/415 ,  Y02A50/419 ,  Y02A50/422 ,  Y02A50/463 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/479 ,  Y02A50/491

摘要： Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disorders, for example, for treatment of infectious diseases.

公开(公告)号：US20170305899A1

公开(公告)日：2017-10-26

申请号：US15342056

申请日：2016-11-02

申请人： Fred Hutchinson Cancer Research Center ,  The Scripps Research Institute

发明人： Gerald R. Smith ,  Susan K. Amundsen ,  Ahmet C. Karabulut ,  Thomas D. Bannister ,  Reji Narayanan Nair

IPC分类号： C07D471/04 ,  A61K31/497 ,  A61K31/5365 ,  C12Q1/44 ,  A61K31/495 ,  C12Q1/18 ,  A61K31/519

CPC分类号： C07D471/04 ,  A61K31/495 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5365 ,  C12Q1/18 ,  C12Q1/44 ,  G01N2333/922 ,  G01N2500/04 ,  G01N2500/10 ,  Y02A50/401 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

摘要： Disclosed herein are compounds and methods for inhibiting bacterial DNA repair enzymes, including AddAB and RecBCD helicase-nucleases. Pharmaceutical compositions and methods for treating a subject with an antibacterial agent are also disclosed herein.

公开(公告)号：US20170275334A1

公开(公告)日：2017-09-28

申请号：US15618337

申请日：2017-06-09

申请人： RQX Pharmaceuticals, Inc.

发明人： Robert I. HIGUCHI ,  Tucker Curran ROBERTS ,  Peter Andrew SMITH ,  David CAMPBELL ,  Prasuna PARASELLI

IPC分类号： C07K7/06 ,  A61K38/07 ,  A61K45/06 ,  C07K5/11 ,  A61K38/06 ,  A61K38/08 ,  C07K5/08 ,  C07K5/113 ,  C07K5/103 ,  C07K5/117

CPC分类号： C07K7/06 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  C07K5/08 ,  C07K5/1013 ,  C07K5/1019 ,  C07K5/1021 ,  C07K5/1024 ,  Y02A50/401 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/483

摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.