公开(公告)号：US4092475A

公开(公告)日：1978-05-30

申请号：US675355

申请日：1976-04-09

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/20 ,  C07D501/36

CPC classification number: C07D333/24

Abstract: Trifluoroalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.4 is hydrogen or lower alkyl; R.sub.5 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups are disclosed. These compounds are useful as antibacterial agents.

Abstract translation: 其中R是氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，成盐离子或基团R 1的三氟烷基脲基头孢菌素是氢或 甲氧基 A是1至6个碳的直链或支链亚烷基; R2是氢或低级烷基; R3是氢，低级烷基，环烷基，环烯基，环烷二烯基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基或某些杂环基; R4是氢或低级烷基; R5是低级烷基; 并且X是氢，低级烷酰氧基，或者某些杂硫基。 这些化合物可用作抗菌剂。

公开(公告)号：US4052554A

公开(公告)日：1977-10-04

申请号：US714890

申请日：1976-08-16

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/36 ,  A61K31/545

CPC classification number: C07D333/24

Abstract: Ureido cephalosporin derivatives of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl or phenyl-lower alkyl, or certain heterocyclic groups; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or methoxy; R.sub.4 is hydrogen, halogen, lower alkyl, or lower alkoxy; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl, phenyl, or phenyl-lower alkyl; are disclosed. These compounds are useful as anti-bacterial agents.

公开(公告)号：US4052393A

公开(公告)日：1977-10-04

申请号：US669114

申请日：1976-03-22

Applicant: Uwe D. Treuner

Inventor： Uwe D. Treuner

IPC: A61K31/495 ,  A61K31/535 ,  A61P29/00 ,  C07D231/14 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D231/14

Abstract: New 4-substituted derivatives of pyrazolo[1,5-a]-quinoxaline-3-carboxylic acid, esters and their salts have the formula ##STR1## R.sub.1 is hydrogen, lower alkyl or a salt forming ion; R.sub.2 is hydrogen, lower alkyl, phenyl-lower alkylene or amino-lower alkylene; R.sub.3 is hydrogen, lower alkyl, halogen or lower alkoxy; and X is oxygen or sulfur.The new compounds are useful as anti-inflammatory agents.

公开(公告)号：US4022782A

公开(公告)日：1977-05-10

申请号：US715601

申请日：1976-08-18

Applicant: Uwe D. Treuner

Inventor： Uwe D. Treuner

IPC: C07D231/14 ,  C07D487/04

CPC classification number: C07D231/14

Abstract: New 4-amino derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##STR1## R.sub.1 is hydrogen, lower alkyl or a salt forming ion; R.sub.2 and R.sub.3 each is hydrogen, lower alkyl, cyclo-lower alkyl, phenyl, substituted phenyl, phenyl-lower alkylene, di-lower alkylamino-lower alkylene or R.sub.2 and R.sub.3 together with the nitrogen form an unsubstituted or substituted 5- or 6-membered nitrogen heterocyclic in which an additional nitrogen or oxygen may be present.R.sub.4 is hydrogen, lower alkyl or halogen.The new compounds are useful as anti-inflammatory agents.

Abstract translation: 吡唑并[1,5-a]喹喔啉-3-羧酸的新4-氨基衍生物，酯及其盐具有下式：R1是氢，低级烷基或成盐离子; R 2和R 3各自为氢，低级烷基，环低级烷基，苯基，取代的苯基，苯基 - 低级亚烷基，二低级烷基氨基 - 低级亚烷基，或者R 2和R 3与氮一起形成未取代或取代的5-或6- 其中可能存在另外的氮或氧。

公开(公告)号：US4005081A

公开(公告)日：1977-01-25

申请号：US612387

申请日：1975-09-11

Applicant: Tetsuo Miyadera ,  Hermann Breuer ,  Uwe D. Treuner

Inventor： Tetsuo Miyadera ,  Hermann Breuer ,  Uwe D. Treuner

IPC: C07D501/56 ,  C07D501/57

CPC classification number: C07D501/57

Abstract: 7.alpha.-Methoxy-7.beta.-tetrazolylmethylthioacetamido-3-cephem derivatives which have a heterothiomethyl substituent in the 3-position are novel compounds which are useful as antimicrobial agents.

Abstract translation: 在3-位上具有异硫代甲基取代基的7α-甲氧基-7β-四唑基甲硫基乙酰氨基-3-头孢烯衍生物是可用作抗微生物剂的新化合物。

公开(公告)号：US3960850A

公开(公告)日：1976-06-01

申请号：US468716

申请日：1974-05-10

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07C68/02 ,  C07D501/20 ,  C07D501/36

CPC classification number: C07D501/20 ,  C07C68/02

Abstract: 3-Heterothio derivatives of [(alkoxycarbonyl)oxyacetyl]cephalosporins which have the formula ##SPC1## tri(lowerWherein R.sub.1 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl or certain heterocyclic groups; R.sub.2 is lower alkyl; R.sub.3 is hydrogen, lower alkyl, tri(lower alkyl)silyl, tri(lowe alkyl)stannyl, a salt forming ion, or ##EQU1## R is lower alkyl, phenyl, or phenyl-lower alkyl; R.sub.4 is a five-membered nitrogen and sulfur or oxygen-containing ring system; are useful as antibacterial agents.

Abstract translation: 具有式（3）的（（低级）WHEREIN R 1是氢，低级烷基，苯基，苯基 - 低级烷基或某些杂环基的[（烷氧基羰基）氧乙酰基]头孢菌素的3-异硫脲衍生物; R 2是低级烷基; R 3是氢，低级烷基， 三（低级烷基）甲硅烷基，三（低级烷基）甲锡烷基，形成盐的离子或O并原-CH2-OCR; R是低级烷基，苯基或苯基 - 低级烷基; R4是五元氮和硫或 含氧环系;可用作抗菌剂。

公开(公告)号：US3943130A

公开(公告)日：1976-03-09

申请号：US533901

申请日：1974-12-18

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07D501/20

CPC classification number: C07C329/00

Abstract: [[(Thioalkoxy)thiocarbonyl]oxy]acetyl cephalosporin derivatives of the general formula ##SPC1##Wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri-(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU1## is hydrogen, lower alkyl, phenyl, thienyl, furyl or pyridyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is hydrogen, lower alkanoyloxy, azido or pyridyl; R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract translation: [[（硫代烷氧基）硫代羰基]氧基]乙酰头孢菌素衍生物，其通式为：其中R是氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲锡烷基，三（低级烷基）甲硅烷基，成盐离子或 基团O分子-CH2-OC-R4; 是氢，低级烷基，苯基，噻吩基，呋喃基或吡啶基; R2是低级烷基或苯基 - 低级烷基; R3是氢，低级烷酰氧基，叠氮基或吡啶基; R4是低级烷基，苯基或苯基 - 低级烷基; 作为抗菌剂是有用的。