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294 条记录 (耗时 0.034 秒)

    3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    83.
    发明授权
    3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效
    3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途

    公开(公告)号：US07700596B2

    公开(公告)日：2010-04-20

    申请号：US12161905

    申请日：2007-02-09

    申请人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    发明人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    IPC分类号： A61K31/495

    CPC分类号： C07D471/08

    摘要： 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.

    摘要翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。 此外，在治疗方法中使用这些化合物和包含该化合物的药物组合物。 3,9-二氮杂双环[3.3.1]壬烷衍生物具有下式其中Ra和Rb如申请中所述。 还公开了化合物的立体异构体和药学上可接受的盐。

    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors
    87.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors 失效
    可用作烟碱乙酰胆碱受体调节剂的1,4-二氮杂双环[3.2.2]壬基恶二唑基衍生物

    公开(公告)号：US08106042B2

    公开(公告)日：2012-01-31

    申请号：US12921922

    申请日：2009-03-09

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Eva Dam Christoffersen

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Eva Dam Christoffersen

    IPC分类号： A61P25/00 ,  A61K31/551 ,  C07D471/08

    CPC分类号： C07D471/08

    摘要： This invention relates to novel N-oxides of a 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivative and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物的新型N-氧化物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。