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    Cooling system
    83.
    再颁专利
    Cooling system 有权
    冷却系统

    公开(公告)号：USRE43007E1

    公开(公告)日：2011-12-06

    申请号：US12173536

    申请日：2008-07-15

    申请人： Jean-Pierre Lalonde ,  Marwan Abboud ,  Rachid Mahrouche ,  Dan Wittenberger

    发明人： Jean-Pierre Lalonde ,  Marwan Abboud ,  Rachid Mahrouche ,  Dan Wittenberger

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.

    摘要翻译： 低温医疗系统包括在连接点处可连接到医疗装置的医疗装置和控制台。 控制台控制医疗设备的温度。 所述控制台包括第一冷却系统，所述第一冷却系统沿着冷却剂供应管线在第一温度下将冷却剂引导至所述医疗设备;以及第二冷却系统，在所述冷却剂到达所述连接点之前将所述冷却剂供应管线内的冷却剂冷却至低于所述第一温度的温

    Method and device for epicardial ablation
    85.
    发明授权
    Method and device for epicardial ablation 失效
    心外膜消融的方法和装置

    公开(公告)号：US07625369B2

    公开(公告)日：2009-12-01

    申请号：US11526494

    申请日：2006-09-25

    申请人： Marwan Abboud ,  Dan Wittenberger ,  Daniel Nahon ,  Steven G. Arless

    发明人： Marwan Abboud ,  Dan Wittenberger ,  Daniel Nahon ,  Steven G. Arless

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02

    摘要： A method is disclosed for treating heart and vascular tissue with cryotreatment. A medical instrument, such as a catheter is positioned to contact a target region of cardiac tissue such as the epicardial tissue. The instrument or catheter provided includes a cryotreatment element that has thermally-transmissive properties. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of heart or vascular tissue to be treated, usually by piercing the epicardium sac via an opening in the patient's body. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the targeted heart or vascular tissue, inducing hypothermia and forming iceballs proximate the tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue.

    摘要翻译： 公开了一种用冷冻治疗来治疗心脏和血管组织的方法。 诸如导管的医疗器械定位成接触诸如心外膜组织的心脏组织的靶区域。 提供的仪器或导管包括具有热传递特性的冷冻处理元件。 冷冻处理元件可以是用于封闭其中的流体制冷剂的流动的冷冻箱。 冷冻治疗元件设置在待治疗的心脏或血管组织的位置，通常通过穿过患者体内的开口刺穿心外膜。 冷冻箱内的制冷剂流动相对于目标心脏或血管组织产生吸热冷却，诱导低体温并在组织附近形成冰球。 冷却可以是可逆的和非永久性的，或者可能是永久性的导致细胞死亡，坏死，凋亡和/或手术切除或消融组织。

    Variable geometry cooling chamber
    86.
    发明申请
    Variable geometry cooling chamber 有权
    可变几何冷却室

    公开(公告)号：US20080009851A1

    公开(公告)日：2008-01-10

    申请号：US11476928

    申请日：2006-06-28

    申请人： Dan Wittenberger ,  Marwan Abboud ,  Ioana Deac

    发明人： Dan Wittenberger ,  Marwan Abboud ,  Ioana Deac

    IPC分类号： A61B18/18

    CPC分类号： A61B18/02 ,  A61B2017/00256 ,  A61B2017/00867 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M29/02 ,  A61M2025/1093 ,  A61M2029/025

    摘要： The present invention provides a medical device that may include a catheter body having proximal and distal portions, a fluid injection lumen disposed within elongate body, and a guidewire lumen disposed within the elongate body. A tip portion defining a cavity in fluid communication with the fluid injection lumen may be coupled to the distal end of the guidewire lumen, and an expandable element may be coupled to the distal portion of the catheter body and to the tip portion, such that the expandable element is in fluid communication with the fluid injection lumen. A shaping element may at least partially surround the expandable element, where the shaping element is configurable in a first geometric configuration and a second geometric configuration.

    摘要翻译： 本发明提供一种医疗装置，其可以包括具有近端部分和远端部分的导管主体，设置在细长主体内的流体注射内腔和设置在细长主体内的导丝管腔。 限定与流体注射腔流体连通的空腔的尖端部分可以联接到导丝管腔的远端，并且可扩张元件可以联接到导管主体的远端部分和尖端部分，使得 可膨胀元件与流体注射内腔流体连通。 成形元件可以至少部分地围绕可膨胀元件，其中成形元件可配置为第一几何配置和第二几何配置。

    Method and device for epicardial ablation
    87.
    发明申请
    Method and device for epicardial ablation 失效
    心外膜消融的方法和装置

    公开(公告)号：US20070021741A1

    公开(公告)日：2007-01-25

    申请号：US11526494

    申请日：2006-09-25

    申请人： Marwan Abboud ,  Dan Wittenberger ,  Daniel Nahon ,  Steven Arless

    发明人： Marwan Abboud ,  Dan Wittenberger ,  Daniel Nahon ,  Steven Arless

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02

    摘要： A method is disclosed for treating heart and vascular tissue with cryotreatment. A medical instrument, such as a catheter is positioned to contact a target region of cardiac tissue such as the epicardial tissue. The instrument or catheter provided includes a cryotreatment element that has thermally-transmissive properties. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of heart or vascular tissue to be treated, usually by piercing the epicardium sac via an opening in the patient's body. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the targeted heart or vascular tissue, inducing hypothermia and forming iceballs proximate the tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue.

    摘要翻译： 公开了一种用冷冻治疗来治疗心脏和血管组织的方法。 诸如导管的医疗器械定位成接触诸如心外膜组织的心脏组织的靶区域。 提供的仪器或导管包括具有热传递特性的冷冻处理元件。 冷冻处理元件可以是用于封闭其中的流体制冷剂的流动的冷冻箱。 冷冻治疗元件设置在待治疗的心脏或血管组织的位置，通常通过穿过患者体内的开口刺穿心外膜。 冷冻箱内的制冷剂流动相对于目标心脏或血管组织产生吸热冷却，诱导低体温并在组织附近形成冰球。 冷却可以是可逆的和非永久性的，或者可能是永久性的导致细胞死亡，坏死，凋亡和/或手术切除或消融组织。

    Method and device for epicardial ablation
    88.
    发明申请
    Method and device for epicardial ablation 有权
    心外膜消融的方法和装置

    公开(公告)号：US20050010201A1

    公开(公告)日：2005-01-13

    申请号：US10839979

    申请日：2004-05-04

    申请人： Marwan Abboud ,  Dan Wittenberger ,  Daniel Nahon ,  Steven Arless

    发明人： Marwan Abboud ,  Dan Wittenberger ,  Daniel Nahon ,  Steven Arless

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02

    摘要： A method is disclosed for treating heart and vascular tissue with cryotreatment. A medical instrument, such as a catheter is positioned to contact a target region of cardiac tissue such as the epicardial tissue. The instrument or catheter provided includes a cryotreatment element that has thermally-transmissive properties. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of heart or vascular tissue to be treated, usually by piercing the epicardium sac via an opening in the patient's body. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the targeted heart or vascular tissue, inducing hypothermia and forming iceballs proximate the tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue.

    摘要翻译： 公开了一种用冷冻治疗来治疗心脏和血管组织的方法。 诸如导管的医疗器械定位成接触诸如心外膜组织的心脏组织的靶区域。 提供的仪器或导管包括具有热传递特性的冷冻处理元件。 冷冻处理元件可以是用于封闭其中的流体制冷剂的流动的冷冻箱。 冷冻治疗元件设置在待治疗的心脏或血管组织的位置，通常通过穿过患者体内的开口刺穿心外膜。 冷冻箱内的制冷剂流动相对于目标心脏或血管组织产生吸热冷却，诱导低体温并在组织附近形成冰球。 冷却可以是可逆的和非永久性的，或者可能是永久性的导致细胞死亡，坏死，凋亡和/或手术切除或消融组织。

    Catheter
    89.
    发明授权
    Catheter 有权
    导管

    公开(公告)号：US06270476B1

    公开(公告)日：2001-08-07

    申请号：US09298234

    申请日：1999-04-23

    申请人： Domenic Santoianni ,  Daniel Nahon ,  Dan Wittenberger ,  Jean-Pierre Lalonde ,  Cristian Petre

    发明人： Domenic Santoianni ,  Daniel Nahon ,  Dan Wittenberger ,  Jean-Pierre Lalonde ,  Cristian Petre

    IPC分类号： A61M3700

    CPC分类号： A61M25/0144 ,  A61B18/02 ,  A61B2017/003 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M25/00 ,  A61M25/0147

    摘要： A catheter for ablating tissue, for example to treat a cardiac arrhythmia, includes a handle, a shapeable shaft and a distal ablation segment. The shaft retains a first position until manipulated to a further position with the application of moderate manual pressure. The shaft incorporates plastically deformable elements and is shapeable to conform to an insertion path or the particular anatomy of a patient for accessing a site to be ablated. Once shaped, the shaft retains its shape as the catheter is inserted or manipulated to the predetermined tissue treatment location and the distal segment is urged into contact with the tissue site. A deflection mechanism may be provided to facilitate navigation to, or to deflect the ablation segment into conformal contact with, the tissue target. In a further or alternative embodiment, a second or auxiliary shaft member extends distally from the ablation segment, allowing the segment to be threaded by or pulled past occluding tissue to a remote target tissue site. By gripping the end of the second shaft, the flexible ablation segment may be either tensioned or pulled inward against, or flexed and pushed outward against a treatment site, such as a region of the posterior epicardial wall, thus providing more effective contact for a broad range of dispositions and tissue orientations. In another embodiment, a thermal shield extends over a portion of the ablation segment, shielding adjacent tissue from damage while still effectively exposing the target tissue to ablation energy. The shield may be rotated or moved axially to delimit an area of cryogenic contact and achieve better protection of surrounding tissue structures in occluded or remote treatment target regions.

    摘要翻译： 用于烧蚀组织的导管，例如用于治疗心律失常，包括手柄，可成形的轴和远端消融段。 轴保持第一位置，直到操纵到另一个位置，同时施加适度的手动压力。 该轴结合了可塑性变形的元件，并且可变形成符合插入路径或患者的特定解剖结构以访问要消融的部位。 一旦成形，当导管插入或操纵到预定的组织处理位置时，轴保持其形状，并且远端段被推动与组织部位接触。 可以提供偏转机构以便于导航到组织靶或使消融段与组织靶标保形接触。 在另一个或替代的实施例中，第二或辅助轴构件从消融段向远侧延伸，允许该段被螺纹穿过或者通过闭塞组织拉至远端目标组织部位。 通过夹持第二轴的端部，柔性消融段可以被张紧或者向内抵抗抵抗或弯曲并向外抵靠治疗部位（例如后心外膜壁的区域）向外拉，从而为广泛的 配置范围和组织取向。 在另一个实施例中，热屏蔽层延伸在消融段的一部分上，屏蔽相邻组织免受损伤，同时仍然有效地将目标组织暴露于消融能量。 护罩可以旋转或轴向移动以限定低温接触的区域，并且在封闭或远程治疗目标区域中实现对周围组织结构的更好保护。

    Cryosurgical linear ablation
    90.
    发明授权
    Cryosurgical linear ablation 失效
    冷冻外科线性消融

    公开(公告)号：US5899898A

    公开(公告)日：1999-05-04

    申请号：US807382

    申请日：1997-02-27

    申请人： Steven G. Arless ,  Fredric L. Milder ,  Kenneth A. Spector ,  Dan Wittenberger ,  Domenic N. Santoianni ,  Claudia Lueckge

    发明人： Steven G. Arless ,  Fredric L. Milder ,  Kenneth A. Spector ,  Dan Wittenberger ,  Domenic N. Santoianni ,  Claudia Lueckge

    IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61F7/02 ,  A61M25/00 ,  A61B17/36

    CPC分类号： A61B18/02 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61F2007/0298 ,  A61M2025/0039 ,  A61M25/0029

    摘要： A cryogenic catheter includes a flexible member having an elongate, thermally-transmissive region and a cryogenic fluid path through the flexible member to the thermally-transmissive region. The thermally-transmissive region can be deformable from a linear configuration to an arcuate configuration and can include multiple thermally-transmissive elements having a first side exposed to the cryogenic fluid path and a second side exposed to points exterior to the flexible member. The thermally-transmissive elements can be rigid or flexible longitudinal strips. Alternatively, annular, cylidrical, or wedge-shaped metallic structures disposed in a spaced-apart relationship can define the thermally-transmissive region. In other embodiments the thermally-transmissive region is defined by a helical coil that is at least partially embedded in the flexible member. The helical coil can also define at least a portion of the cryogenic fluid path through the flexible member and include a gas expansion or boiling chamber.

    摘要翻译： 低温导管包括具有细长的热透射区域的柔性构件和通过柔性构件到达热传导区域的低温流体路径。 热传导区域可以从线性构造变形到弓形构造，并且可以包括具有暴露于低温流体路径的第一侧的多个热传递元件和暴露于柔性构件外部的点的第二侧。 透光元件可以是刚性或柔性的纵向条。 或者，以间隔开的关系设置的环形，圆形或楔形金属结构可以限定热传导区域。 在其它实施例中，热传导区域由至少部分地嵌入在柔性构件中的螺旋线圈限定。 螺旋线圈还可以限定通过柔性构件的低温流体路径的至少一部分，并且包括气体膨胀或沸腾室。