公开(公告)号：US07076301B1

公开(公告)日：2006-07-11

申请号：US10326746

申请日：2002-12-20

申请人： Mark W. Kroll ,  John W. Poore

发明人： Mark W. Kroll ,  John W. Poore

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61N1/3704 ,  A61N1/3712

摘要： An implantable cardiac stimulation device provides capture of a chamber of a heart with pacing pulses while minimizing parasitic muscle tissue stimulation. A parasitic muscle stimulation detector detects if the application of pacing pulses result in parasitic muscle stimulation. If there is parasitic muscle stimulation resulting from the application of pacing pulses, a pulse generator control adjusts the pacing pulse amplitudes and durations until the pacing pulses capture the chamber of the heart without causing parasitic muscle stimulation.

摘要翻译： 可植入的心脏刺激装置提供用起搏脉冲捕获心脏室，同时最小化寄生肌肉组织刺激。 寄生肌肉刺激检测器检测起搏脉冲的应用是否导致寄生肌肉刺激。 如果由施加起搏脉冲引起的寄生肌肉刺激，则脉冲发生器控制调节起搏脉冲幅度和持续时间，直到起搏脉冲捕获心脏室而不引起寄生肌肉刺激。

公开(公告)号：US06622045B2

公开(公告)日：2003-09-16

申请号：US09823374

申请日：2001-03-29

申请人： Jeffery D. Snell ,  John W. Poore ,  Jason A. Sholder

发明人： Jeffery D. Snell ,  John W. Poore ,  Jason A. Sholder

IPC分类号： A61N108

CPC分类号： A61N1/37282

摘要： To permit remote programming of implantable cardiac stimulation devices such as pacemakers, a central device programmer is provided in conjunction with a network of remote telemetry units for use in patient homes or in remote clinics. To reprogram a device implanted within a patient, a physician enters programming commands within the central programmer which relays the programming commands to a remote telemetry unit in proximity to the patient. The remote telemetry unit, in turn, forwards the programming commands to the implanted device. In this manner, the patient need not return to the physician for reprogramming of the device. Remote telemetry units may be provided within patient homes, clinics, hospital emergency rooms, hospital patient rooms, and the like. Depending upon the implementation, different levels of programmability may be permitted depending upon the degree of supervision of the patient. For an unsupervised patient, limited programmability is permitted. For a nurse-supervised patient, a greater degree of programmability is permitted. Finally, for a physician-supervised patient, a full range of programmability is permitted. In a specific example described herein, each remote telemetry unit includes minimal hardware and software components necessary to relay programming commands, diagnostic information, and other signals between the central programmer and the implanted device.

公开(公告)号：US5697959A

公开(公告)日：1997-12-16

申请号：US584574

申请日：1996-01-11

申请人： John W. Poore

发明人： John W. Poore

IPC分类号： A61N1/372 ,  G06F19/00 ,  A61N1/362 ,  A61N1/37

CPC分类号： A61N1/37247 ,  G06F19/3406 ,  G06F19/345 ,  G06F19/3487

摘要： A method and system for analyzing and displaying pacing event data of an implantable pacemaker using a programmer device comprises downloading the pacing event data from the implantable pacemaker to the programmer device and processing the pacing event data to produce an Event Record. The Event Record includes actual pacing event data obtained and stored by the implantable pacemaker over a prescribed period of time as well as various statistical information derived therefrom. Selected parametric data of the Event Record are then displayed to the physician or other user on a display screen of the programmer device in a simple and comprehensible graphical format.

摘要翻译： 用于使用编程器装置分析和显示可植入起搏器的起搏事件数据的方法和系统包括将起搏事件数据从可植入起搏器下载到编程器装置并处理起搏事件数据以产生事件记录。 事件记录包括在规定的时间段内由可植入心脏起搏器获得和存储的实际起搏事件数据以及从其导出的各种统计信息。 事件记录的所选择的参数数据然后以简单且易于理解的图形格式显示给编程器设备的显示屏上的医生或其他用户。

公开(公告)号：US5431691A

公开(公告)日：1995-07-11

申请号：US846460

申请日：1992-03-02

申请人： Jeffery D. Snell ,  Harold C. Schloss ,  Brian M. Mann ,  John W. Poore ,  Roy B. Medlin

发明人： Jeffery D. Snell ,  Harold C. Schloss ,  Brian M. Mann ,  John W. Poore ,  Roy B. Medlin

IPC分类号： A61N1/37 ,  A61N1/372

CPC分类号： A61N1/37247 ,  A61N1/37

摘要： An implantable pacemaker continuously records pacing events and their respective rates of occurrence in sequence, as they occur, into an Event Record stored in a circular buffer. The circular buffer always contains the most recent events and rates collected. The recording of the pacing events selectively occurs at every event, or at sampling rates of one event per fixed sample interval. A programming device, coupled to the implantable pacemaker through a telemetry link, selectively retrieves the recorded pacing events and rates from the Event Record and reports subsets thereof in condensed or summarized form using numerical and/or graphical formats. The pacing event data collected in the Event Record is three-dimensional in that each pacing event includes a pacemaker event, an associated pacemaker or heart rate, and a real time interval. The programming device also calculates and reports statistical information from the data collected in the Event Record. The Event Record provides a base recording that establishes the behavior of the pacemaker in a particular patient under ascertainable conditions.

摘要翻译： 植入式起搏器将发生的起搏事件及其各自发生的发生顺序连续记录到存储在循环缓冲器中的事件记录中。 循环缓冲区总是包含最近收集的事件和速率。 起搏事件的记录选择性地发生在每个事件或每个固定采样间隔的一个事件的采样率。 通过遥测链路耦合到可植入心脏起搏器的编程设备选择性地从事件记录中检索所记录的起搏事件和速率，并使用数字和/或图形格式以浓缩或概括形式报告子集。 事件记录中收集的起搏事件数据是三维的，因为每个起搏事件包括起搏器事件，相关起搏器或心率以及实时间隔。 编程设备还根据事件记录中收集的数据计算和报告统计信息。 事件记录提供基准记录，确定特定病人在确定条件下的起搏器的行为。

公开(公告)号：US5423867A

公开(公告)日：1995-06-13

申请号：US844807

申请日：1992-03-02

申请人： John W. Poore ,  Brian M. Mann ,  Roy B. Medlin

发明人： John W. Poore ,  Brian M. Mann ,  Roy B. Medlin

IPC分类号： A61N1/365 ,  A61N1/362

CPC分类号： A61N1/36514

摘要： A programmable offset is added to an automatically generated baseline reference value to provide a Threshold value used by the rate-responsive sensor processing circuits of an implantable rate-responsive pacemaker to determine the significance of a sensor input signal. The rate-responsive pacemaker provides stimulation pulses on demand at a pacing rate determined by a sensed physiological parameter. The physiological parameter is sensed by a physiological sensor included within, or coupled to, the rate-responsive pacemaker. The physiological sensor generates a sensor input signal having a magnitude that varies as a function of the sensed physiological parameter. The invention provides a way for the rate-responsive pacemaker, when operating in an autothreshold mode, to automatically determine when the magnitude of the sensor input signal is sufficiently large to justify an increase in the pacing rate. A long-term running average of the sensor input signal is continuously maintained, and is used as a baseline threshold value. A programmable offset is added to the baseline reference value. Any sensor input signal that exceeds the baseline reference value plus the programmable offset is considered to be sufficiently large to effect an increase in the pacing rate.

摘要翻译： 将可编程偏移量添加到自动生成的基线参考值，以提供由可植入速率响应起搏器的速率响应传感器处理电路使用的阈值，以确定传感器输入信号的重要性。 速率响应起搏器根据感测的生理参数在起搏速率下根据需要提供刺激脉冲。 生理参数由包括在速率响应起搏器内或耦合到速率响应起搏器的生理传感器感测。 生理传感器产生具有随检测到的生理参数的函数而变化的量值的传感器输入信号。 本发明提供了一种速率响应起搏器在以自动阈值模式操作时自动确定传感器输入信号的幅度何时足够大以证明起搏速率增加的方式。 传感器输入信号的长期运行平均值连续保持，并用作基准阈值。 可编程偏移量被添加到基准参考值。 超过基线参考值加上可编程偏移量的任何传感器输入信号被认为足够大，以达到起搏速率的增加。

公开(公告)号：US5417718A

公开(公告)日：1995-05-23

申请号：US240042

申请日：1994-05-09

申请人： Jonathan A. Kleks ,  Stuart W. Buchanan ,  Raymond J. Wilson ,  John W. Poore ,  Brian M. Mann

发明人： Jonathan A. Kleks ,  Stuart W. Buchanan ,  Raymond J. Wilson ,  John W. Poore ,  Brian M. Mann

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3712 ,  A61N1/3716

摘要： An autocapture system within an implantable pulse generator automatically maintains the energy of a stimulation pulse at a level just above that which is needed to effectuate capture. The electrical post-stimulus signal of the heart following delivery of a stimulation pulse is compared to a polarization template, determined during a capture verification test. A prescribed difference between the polarization template and the post-stimulus signal indicates capture has occurred. Otherwise, loss of capture is presumed, and a loss-of-capture routine is invoked that increases the energy a prescribed amount to obtain capture. Periodically, and/or at programmed intervals or events, the capture verification test is performed. During the capture verification test, the pulse generator determines a polarization template for a particular stimulation energy and for each of a plurality of sensitivity or threshold settings. A determination is also made as to which sensitivity settings yield capture. An autocapture routine extends the capture verification test data to a wide range of stimulation energies. An autothreshold routine automatically sets the energy of the stimulation pulse a specified level above the energy at which capture is first lost.

摘要翻译： 可植入脉冲发生器内的自动捕获系统自动将刺激脉冲的能量维持在刚好高于实现捕获所需的水平的水平。 输送刺激脉冲后心脏的电刺激后信号与在捕获验证测试期间确定的极化模板进行比较。 偏振模板和后刺激信号之间的规定的差异表明已经发生捕获。 否则，假设捕获的丢失，并且调用丢失捕获程序，将能量增加到规定的量以获得捕获。 周期性地和/或以编程间隔或事件进行捕获验证测试。 在捕获验证测试期间，脉冲发生器确定用于特定刺激能量和多个灵敏度或阈值设置中的每一个的偏振模板。 还决定哪个灵敏度设置产生捕获。 自动捕获程序将捕获验证测试数据扩展到广泛的刺激能量。 自动阈值程序自动将刺激脉冲的能量设置在高于捕获首次丢失的能量的指定水平。

公开(公告)号：US5387229A

公开(公告)日：1995-02-07

申请号：US7648

申请日：1993-01-21

申请人： John W. Poore

发明人： John W. Poore

IPC分类号： A61N1/365 ,  A61N1/36

CPC分类号： A61N1/36585

摘要： A rate-response pacemaker includes a plurality of sensors that each sense a physiologic-related parameter suggestive of the physiological needs of a patient, and hence, indicative of the pacing rate at which the rate-responsive pacemaker should provide pacing pulses on demand. The pacemaker includes appropriate selection circuitry for selecting which of the sensor parameters, or weighted combinations thereof, should be used as the sensor indicated rate (SIR) signal to control the pacing rate of the pacemaker at any given time. The pacemaker also includes a memory circuit for selectively storing the sensor parameters from each of the plurality of sensors. The stored sensor parameters may thereafter be downloaded from the pacemaker memory and evaluated in non-real time with the various sensor parameters assuming different weighting (scaling) factors and different processing parameters (e.g., filtering), thereby allowing an optimum combination of the sensor parameters to be determined without requiring repeated trials by the patient.

摘要翻译： 速率响应起搏器包括多个传感器，每个传感器感测到提示患者的生理需要的生理相关参数，并且因此指示速率响应起搏器应该根据需要提供起搏脉冲的起搏速率。 起搏器包括适当的选择电路，用于选择哪些传感器参数或其加权组合应当用作传感器指示速率（SIR）信号，以控制起搏器在任何给定时间的起搏速率。 起搏器还包括用于选择性地存储来自多个传感器中的每一个的传感器参数的存储器电路。 存储的传感器参数此后可以从起搏器存储器下载，并且以假设不同的加权（缩放）因子和不同的处理参数（例如，滤波）的各种传感器参数非实时地进行评估，从而允许传感器参数的最佳组合 要确定，而不需要患者的反复试验。

公开(公告)号：US5309919A

公开(公告)日：1994-05-10

申请号：US846461

申请日：1992-03-02

申请人： Jeffery D. Snell ,  Harold C. Schloss ,  Brian M. Mann ,  John W. Poore ,  Roy B. Medlin

发明人： Jeffery D. Snell ,  Harold C. Schloss ,  Brian M. Mann ,  John W. Poore ,  Roy B. Medlin

IPC分类号： A61N1/37 ,  A61N1/372 ,  A61B5/0452

CPC分类号： A61N1/37247 ,  A61N1/3702

摘要： A method and system for monitoring the behavior of an implanted pacemaker counts (records) the number of times that a given internal event or state change of the pacemaker occurs, and also determines the rate at which each event or state change thus counted occurs. The event counts and their associated rate are stored (recorded) in appropriate memory circuits housed within the pacemaker device. At an appropriate time, the stored event count and rate data are downloaded to an external programming device. The external programming device processes the event count and rate data, and displays a distribution of the event count data as a function of its rate of occurrence, as well as other statistical information derived therefrom. The displayed information, and its associated statistical information, allows a baseline recording to be made that establishes the implanted pacemaker's behavior for a given patient under known conditions. Such baseline recording of event counts in combination with the associated rate of occurrence of such event counts provides significant insight into the past behavior of the pacemaker as implanted in a particular patient. The past behavior of the pacemaker, in turn, may then be used to predict with a high degree of accuracy the future behavior of the pacemaker.

摘要翻译： 用于监测植入式起搏器的行为的方法和系统计数（记录）发生起搏器的给定内部事件或状态改变的次数，并且还确定发生每个事件或状态改变的速率。 事件计数及其相关速率被存储（记录）在安置在起搏器装置内的适当的存储器电路中。 在适当的时间，存储的事件计数和速率数据被下载到外部编程设备。 外部编程设备处理事件计数和速率数据，并且显示作为其发生速率的函数的事件计数数据的分布以及从其导出的其他统计信息。 显示的信息及其相关的统计信息允许进行基线记录，以在已知条件下确定给定患者的植入式心脏起搏器的行为。 事件计数的这种基线记录与这种事件计数的相关发生率相结合提供了对植入在特定患者中的起搏器的过去行为的显着了解。 起搏器的过去行为反过来可能被用来高精度地预测起搏器未来的行为。

公开(公告)号：US4890774A

公开(公告)日：1990-01-02

申请号：US186492

申请日：1988-04-26

申请人： John W. Poore

发明人： John W. Poore

IPC分类号： B67D1/12 ,  B67D1/00 ,  B67D1/04 ,  B67D1/14

CPC分类号： B67D1/127 ,  B67D1/0037 ,  B67D1/1213

摘要： In a beverage dispenser of the type including portion control dispensing, the improvement wherein the portion control circuit includes a microprocessor based timer programmed to provide a primary pour cycle and then one or more topping off pour cycles after a wait period of time after termination of the primary pour cycle.

摘要翻译： 在包括部分控制分配的类型的饮料分配器中，改进之处在于，部分控制电路包括基于微处理器的计时器，其被编程为在终止后的等待时间段之后提供主要倾倒循环，然后一次或多次排出倾倒循环 初次循环。

公开(公告)号：US07840246B1

公开(公告)日：2010-11-23

申请号：US11282198

申请日：2005-11-17

申请人： John W. Poore

发明人： John W. Poore

IPC分类号： A61B5/1455

CPC分类号： A61B5/14542 ,  A61B5/14535 ,  A61B5/1459 ,  A61B5/1495

摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

摘要翻译： 测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。 校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度 光源。 基于由校准光检测器产生的校准信号来补偿透射光强度的变化。 本说明书不是对本发明的完整描述或限制本发明的范围。 本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。