公开(公告)号：US20240350093A1

公开(公告)日：2024-10-24

申请号：US18648953

申请日：2024-04-29

Applicant: Itamar Medical Spry 2021, Limited Partnership

Inventor： Elad Ferber ,  Pierre-Jean Cobut ,  Ramkrishnan Narayanan ,  Derya Gol Gungor

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/117 ,  A61B5/145 ,  A61B5/1455 ,  G16H40/67

CPC classification number: A61B5/7221 ,  A61B5/0002 ,  A61B5/0008 ,  A61B5/0022 ,  A61B5/0064 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02125 ,  A61B5/02141 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/0806 ,  A61B5/0816 ,  A61B5/117 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/4872 ,  A61B5/6802 ,  A61B5/6816 ,  A61B5/6823 ,  A61B5/6824 ,  A61B5/6829 ,  A61B5/7203 ,  A61B5/721 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/7435 ,  G16H40/67

Abstract: Systems and methods for determining if a wearable photoplethysmography device is correctly positioned in operating to medical signs of a user by using a classifier to determine if a signal is valid or invalid. In some embodiments, in using the classifier to determine in a signal is valid or invalid, a lean method of linear computational complexity and minimal memory complexity is provided for determining at the wearable photoplethysmography device if it is correctly positioned. In some embodiments, in using the classifier minimal computational complexity is used in determining at the wearable photoplethysmography device if it is correctly positioned.

公开(公告)号：US20240307000A1

公开(公告)日：2024-09-19

申请号：US18605926

申请日：2024-03-15

Applicant: Itamar Medical Spry 2021, Limited Partnership

Inventor： Elad Ferber ,  Pierre-Jean Cobut ,  Ramkrishnan Narayanan ,  Derya Gol Gungor

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/117 ,  A61B5/145 ,  A61B5/1455 ,  G16H40/67

CPC classification number: A61B5/7221 ,  A61B5/0002 ,  A61B5/0008 ,  A61B5/0022 ,  A61B5/0064 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02125 ,  A61B5/02141 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/0806 ,  A61B5/0816 ,  A61B5/117 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/4872 ,  A61B5/6802 ,  A61B5/6816 ,  A61B5/6823 ,  A61B5/6824 ,  A61B5/6829 ,  A61B5/7203 ,  A61B5/721 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/7435 ,  G16H40/67

Abstract: Systems and methods for non-invasive blood pressure measurement are disclosed. In some embodiments, a system comprises a wearable member configured to generate first and second signals, and a blood pressure calculation system. The blood pressure calculation system a pre-processing module configured to filter noise from the signals, and a wave selection module configured to identify subsets of waves of the signals, a feature extraction module configured to generate sets of feature vectors form the subsets of waves, and a blood pressure processing module configured to calculate an arterial blood pressure value based on the sets of feature vectors and an empirical blood pressure calculation model, the empirical blood pressure calculation model configured to receive the sets of feature vectors as input values. The blood pressure calculation system further includes a communication module configured to provide a message including or being based on the arterial blood pressure value.

公开(公告)号：US20240277246A1

公开(公告)日：2024-08-22

申请号：US18566924

申请日：2022-06-03

Applicant: IC Targets AS

Inventor： Jonny ØSTENSEN ,  Willy EIDSAUNET

IPC: A61B5/055 ,  A61B5/00 ,  A61B5/145 ,  A61K49/10 ,  G01R33/50 ,  G01R33/56 ,  G01R33/563

CPC classification number: A61B5/055 ,  A61B5/0044 ,  A61B5/14535 ,  A61K49/106 ,  G01R33/50 ,  G01R33/5601 ,  G01R33/56366

Abstract: The present invention relates to manganese-enhanced MRI, more specifically to a method for determining a cardiomyocyte cellular manganese uptake rate of a subject, contrast agent comprising a manganese contrast agent, or a pharmaceutically acceptable salt thereof, for use in a method for in vivo diagnosis of heart disease in a subject, a computer-implemented method of determining a cardiomyocyte cellular manganese uptake rate in a subject, a data processing apparatus comprising means for carrying out said computer-implemented method, a computer program comprising instructions which, when the program is executed by a computer, cause the computer to carry out said computer-implemented method, and a computer-readable medium having stored thereon said computer program.

公开(公告)号：US12029555B2

公开(公告)日：2024-07-09

申请号：US16982317

申请日：2019-03-20

Applicant: GAMBRO LUNDIA AB

Inventor： Paolo Rovatti ,  Enrico Ravagli ,  Stefano Severi

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/02 ,  A61B5/026 ,  A61B5/1455 ,  A61B8/00 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61B5/14535 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/1455 ,  A61B5/6866 ,  A61B8/00 ,  A61M1/1603 ,  A61M1/1619 ,  A61M1/3601 ,  A61M1/3609 ,  A61M1/3612 ,  A61M1/3669 ,  A61B2562/00 ,  A61B2562/04 ,  A61B2562/146 ,  A61B2562/16 ,  A61B2562/164 ,  A61B2562/166 ,  A61B2562/228 ,  A61M1/1605 ,  A61M1/1613 ,  A61M2205/3306 ,  A61M2205/3334

Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit (2), a blood withdrawal line (6), a blood return line (7), a preparation line (19) and a spent dialysate line (13); a non-invasive blood volume sensor (50) for determining an additional property of blood is active on a tube segment (61) of the blood withdrawal line or of the blood return line; the sensor includes one source (53) for directing a signal towards the blood, a plurality of detectors (57) for receiving the signal, and a controller (65) receiving the output signals from the detectors (57) and determining a blood volume variation and a value of sodium concentration in the blood (Napl) both based on the output signals. A process of determining at least one parameter and on property of blood circulating an extracorporeal blood circuit is also disclosed.

公开(公告)号：US11986273B2

公开(公告)日：2024-05-21

申请号：US17381222

申请日：2021-07-21

Applicant: Facense Ltd.

Inventor： Ari M Frank ,  Arie Tzvieli ,  Ori Tzvieli ,  Gil Thieberger

IPC: G01J5/00 ,  A61B5/00 ,  A61B5/01 ,  A61B5/16 ,  G01J5/02 ,  G01J5/12 ,  A61B5/145 ,  G01J5/48

CPC classification number: A61B5/015 ,  A61B5/0075 ,  A61B5/165 ,  A61B5/6803 ,  A61B5/6814 ,  A61B5/7282 ,  A61B5/748 ,  G01J5/0265 ,  G01J5/12 ,  A61B5/0077 ,  A61B5/14535 ,  A61B2562/0271 ,  A61B2562/0276 ,  A61B2576/00 ,  G01J2005/0077 ,  G01J5/485

Abstract: Described herein are embodiments of systems and methods that utilize images of a user's face to detect alcohol intoxication. One embodiment of a system to detect alcohol intoxication includes first and second inward-facing head-mounted cameras that are located less than 5 cm from a user's face, are sensitive to wavelengths below 1050 nanometer, and are configured to capture images of respective first and second regions on the user's face. The system also includes a computer that calculates, based on baseline images captured with the cameras while the user was not intoxicated, a baseline pattern of hemoglobin concentrations at regions on the face. The computer also calculates, based on a current set of images captured with the cameras, a current pattern of hemoglobin concentrations at the regions, and detects whether the user is intoxicated based on a deviation of the current pattern from the baseline pattern.

公开(公告)号：US11969577B1

公开(公告)日：2024-04-30

申请号：US17147112

申请日：2021-01-12

Applicant: Hana Patent Technology, LLC

Inventor： Mandeep Sahani ,  An-Dien Nguyen ,  J. Allan Waitz ,  Linh C. Nguyen

IPC: A61M5/172 ,  A61B5/00 ,  A61B5/145 ,  A61M5/142 ,  G16H20/17 ,  G16H40/67 ,  G16H70/60

CPC classification number: A61M5/1723 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14248 ,  G16H20/17 ,  G16H40/67 ,  G16H70/60 ,  A61M2202/0433 ,  A61M2205/3584 ,  A61M2205/52 ,  A61M2205/8206 ,  A61M2230/20

Abstract: Apparatus(es)/method(s) relating generally to remotely administering a medication is/are disclosed. In one such method, a drug delivery device is obtained. The drug delivery device has: at least one reservoir in fluid communication with a needle; at least one actuator to drive a fluid within a respective at least one reservoir to the needle; a microcontroller to control operation of the at least one actuator; and a dosage control loop configured for communication with the microcontroller and a hemoglobin sensor. A dosage provided by the drug delivery device is automatically adjusted responsive to hemoglobin count sensed by the hemoglobin sensor for transdermal administration of medication for management of chronic kidney disease.

公开(公告)号：US20240016403A1

公开(公告)日：2024-01-18

申请号：US17801506

申请日：2021-04-11

Applicant: ALIO, INC.

Inventor： Andrei AFANASIEV ,  Forrest Miller ,  Francis Honore ,  Anthony Flannery

IPC: A61B5/026 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/0261 ,  A61B5/6833 ,  A61B5/14535 ,  A61B5/14552 ,  A61B5/0022

Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

公开(公告)号：US11779246B2

公开(公告)日：2023-10-10

申请号：US17346433

申请日：2021-06-14

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED

Inventor： Dvir Yelin

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/14551 ,  A61B5/0075 ,  A61B5/14535 ,  A61B5/0068 ,  A61B5/0077 ,  A61B5/441

Abstract: A system and method to measure blood oxygenation levels and total hemoglobin on individually selected blood vessels, to provide a representation of the subject condition and of tissue perfusion that may be used for diagnosing specific tissue conditions. Reflection spectra from individual blood vessels or a collection of vessels are measured by using wide-field imaging for selecting target vessels and a narrow-field confocal detection system to enable measuring local blood oxygenation and hemoglobin. Optical fibers may be used to illuminate the target vessel and to detect light diffusively reflected therefrom. The reflection spectra may be analyzed in a spectrometer to extract the ratio of the deoxy- to oxyhemoglobin and to determine their absolute concentration for computing total hemoglobin levels. An alternative implementation uses image processing on camera images of a blood vessel, generated at an isosbestic wavelength of the deoxy- and oxyhemoglobin, and optionally also at neighboring wavelengths.

公开(公告)号：US11759557B2

公开(公告)日：2023-09-19

申请号：US17034250

申请日：2020-09-28

Applicant: Medtronic, Inc.

Inventor： Martin Gerber ,  John Burnes ,  SuPing Lyu ,  Venkatesh R. Manda ,  Bryant Pudil

IPC: A61M1/16 ,  A61B5/00 ,  A61M1/00 ,  A61B5/053 ,  G16H20/17 ,  G16H40/63 ,  A61B5/145 ,  A61M1/34 ,  A61M1/36 ,  A61M1/14 ,  B01D61/00 ,  B01D61/32 ,  A61B5/0295 ,  A61B5/0537 ,  B01D65/02 ,  G16Z99/00 ,  G16H20/40 ,  A61B5/026 ,  A61M1/28

CPC classification number: A61M1/1603 ,  A61B5/0031 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/6866 ,  A61M1/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/28 ,  A61M1/34 ,  A61M1/342 ,  A61M1/3403 ,  A61M1/361 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/3612 ,  B01D61/00 ,  B01D61/32 ,  B01D65/02 ,  G16H20/17 ,  G16H20/40 ,  G16H40/63 ,  G16Z99/00 ,  A61B2560/0223 ,  A61M2205/04 ,  A61M2205/18 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3375 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/60 ,  A61M2205/70 ,  A61M2230/00 ,  A61M2230/005 ,  A61M2230/20 ,  A61M2230/207 ,  A61M2230/208 ,  A61M2230/65 ,  B01D2321/12 ,  B01D2321/40

Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

公开(公告)号：US20230284939A1

公开(公告)日：2023-09-14

申请号：US18319163

申请日：2023-05-17

Applicant: The General Hospital Corporation

Inventor： Charles P. Lin ,  Hari Prasad Paudel

IPC: A61B5/145 ,  G02B21/14 ,  G02B21/00 ,  A61B5/1455 ,  G01N15/14 ,  A61B5/00 ,  G02B21/08 ,  G02B26/12 ,  G02B21/36

CPC classification number: A61B5/14535 ,  G02B21/14 ,  G02B21/0056 ,  G02B21/008 ,  G02B21/0068 ,  A61B5/1455 ,  G01N15/1436 ,  G02B21/0048 ,  A61B5/0068 ,  G02B21/002 ,  G02B21/086 ,  G02B26/12 ,  G02B21/365 ,  G01N15/1468 ,  G01N2015/144 ,  A61B2562/0233 ,  G01N2015/1006

Abstract: Systems, methods, and apparatus for differential phase contrast microscopy by transobjective differential epi-detection of forward scattered light are provided. In some embodiments, a microscope objective comprises: a housing with mounting threads at a second end; optical components defining an optical axis, comprising: an objective lens mounted at a first end, configured to collect light from a sample placed in a field of view, the plurality of optical components create a pupil plane at a first distance along the optical axis at which rays having the same angle of incidence on the objective lens converge at the same radial distance from the optical axis; a photodetector within the housing offset from the optical axis at a second distance along the optical axis; and another photodetector within the housing at second distance along the optical axis and offset from the optical axis in the opposite direction from the first photodetector.