Amino methyl imidazoles and related compounds as C5a receptor modulators
    81.
    发明授权
    Amino methyl imidazoles and related compounds as C5a receptor modulators 失效
    氨基甲基咪唑和相关化合物作为C5a受体调节剂

    公开(公告)号:US08007767B2

    公开(公告)日:2011-08-30

    申请号:US11615054

    申请日:2006-12-22

    IPC分类号: A61K51/00

    摘要: Amino methyl imidazoles of Formula I are provided: wherein R, R1, R2, R3, R4, R5, and R6 are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.

    摘要翻译: 提供式I的氨基甲基咪唑:其中R,R 1,R 2,R 3,R 4,R 5和R 6在本文中定义。 这些化合物是C5a受体的配体。 优选的式I化合物以高亲和力结合C5a受体,并在C5a受体上呈现中性拮抗剂或反向激动剂活性。 本发明还涉及包含这些化合物的药物组合物。 它还涉及这些化合物在治疗各种炎性,心血管和免疫系统疾病中的用途。 此外,本发明提供标记的氨基甲基咪唑化合物,其可用作C5a受体定位的探针。

    System and Method for Frequency Domain Audio Post-processing Based on Perceptual Masking
    83.
    发明申请
    System and Method for Frequency Domain Audio Post-processing Based on Perceptual Masking 有权
    基于感知掩蔽的频域音频后处理系统和方法

    公开(公告)号:US20110002266A1

    公开(公告)日:2011-01-06

    申请号:US12773638

    申请日:2010-05-04

    申请人: Yang Gao

    发明人: Yang Gao

    IPC分类号: H04W4/00 G10L19/00

    CPC分类号: G10L19/26 G10L25/18

    摘要: In an embodiment, a method of frequency domain post-processing is disclosed. The method includes applying adaptive modification gain factor to each frequency coefficient, and determining gain factors based on Local Masking Magnitude and Local Masked Magnitude.

    摘要翻译: 在一个实施例中,公开了一种频域后处理的方法。 该方法包括对每个频率系数应用自适应修改增益因子,并且基于局部掩蔽幅度和局部掩蔽幅度来确定增益因子。

    Classification of Fast and Slow Signal
    84.
    发明申请
    Classification of Fast and Slow Signal 有权
    快信号分类

    公开(公告)号:US20100063806A1

    公开(公告)日:2010-03-11

    申请号:US12554861

    申请日:2009-09-04

    申请人: Yang Gao

    发明人: Yang Gao

    IPC分类号: G10L11/04 G10L21/00

    摘要: Low bit rate audio coding such as BWE algorithm often encounters conflict goal of achieving high time resolution and high frequency resolution at the same time. In order to achieve best possible quality, input signal can be first classified into fast signal and slow signal. This invention focuses on classifying signal into fast signal and slow signal, based on at least one of the following parameters or a combination of the following parameters: spectral sharpness, temporal sharpness, pitch correlation (pitch gain), and/or spectral envelope variation. This classification information can help to choose different BWE algorithms, different coding algorithms, and different postprocessing algorithms respectively for fast signal and slow signal.

    摘要翻译: 诸如BWE算法之类的低比特率音频编码经常遇到同时实现高时间分辨率和高频分辨率的冲突目标。 为了达到最佳质量,输入信号可以先分为快速信号和慢信号。 本发明集中于基于以下参数中的至少一个或以下参数的组合将信号分类为快速信号和慢信号:频谱清晰度,时间清晰度,音调相关(音调增益)和/或频谱包络变化。 该分类信息有助于分别为快速信号和慢信号选择不同的BWE算法,不同的编码算法和不同的后处理算法。

    Adaptive Approach to Improve G.711 Perceptual Quality
    86.
    发明申请
    Adaptive Approach to Improve G.711 Perceptual Quality 有权
    改善G.711知觉质量的适应性方法

    公开(公告)号:US20090094037A1

    公开(公告)日:2009-04-09

    申请号:US12203052

    申请日:2008-09-02

    申请人: Yang Gao

    发明人: Yang Gao

    IPC分类号: G10L19/00

    摘要: In order to achieve the best improvement of ITU G.711 related codec perceptual quality, perceptual weighting controlling parameter(s) should be at least adaptive to relative quantization error statistics or adaptive to signal level. When the relative quantization error statistics are larger or the signal level is lower, the perceptual weighting should be “stronger”, which means α in (5) is smaller; when the relative quantization error statistics are smaller or the signal level is larger, the perceptual weighting should be “weaker”, which means α in (5) is larger.

    摘要翻译: 为了实现ITU G.711相关编解码感知质量的最佳改进,感知加权控制参数应至少适应于相对量化误差统计或自适应信号电平。 当相对量化误差统计量较大或信号电平较低时,感知权重应该更强,这意味着(5)中的α值较小; 当相对量化误差统计量较小或信号电平较大时,感知权重应该是“弱”,这意味着(5)中的α值较大。

    Method and system for reducing effects of noise producing artifacts in a speech signal
    87.
    发明申请
    Method and system for reducing effects of noise producing artifacts in a speech signal 有权
    用于减少语音信号中噪声产生伪像的影响的方法和系统

    公开(公告)号:US20090070106A1

    公开(公告)日:2009-03-12

    申请号:US12284805

    申请日:2008-09-24

    申请人: Yang Gao Eyal Shlomot

    发明人: Yang Gao Eyal Shlomot

    IPC分类号: G10L19/14

    摘要: There is provided a method of reducing effect of noise producing artifacts in silence areas of a speech signal for use by a speech decoding system. The method comprises obtaining a plurality of incoming samples of a speech subframe; summing an absolute value of an energy level for each of the plurality of incoming samples to generate a total input level (gain_in); smoothing the total input level to generate a smoothed level (Level_in_sm); determining that the speech subframe is in a silence area based on the total input level, the smoothed level and a spectral tilt parameter; defining a gain using k1*(Level_in_sm/1024)+(1−k1), where K1 is a function of the spectral tilt parameter; and modifying an energy level of the speech subframe using the gain.

    摘要翻译: 提供了一种减少由语音解码系统使用的语音信号的静音区域中产生噪声的噪声的影响的方法。 该方法包括获得语音子帧的多个输入样本; 将多个输入样本中的每一个的能级的绝对值求和以产生总输入电平(gain_in); 平滑总输入电平以产生平滑电平(Level_in_sm); 基于总输入电平,平滑电平和频谱倾斜参数,确定语音子帧在静音区域中; 使用k1 *(Level_in_sm / 1024)+(1-k1)定义增益,其中K1是频谱倾斜参数的函数; 以及使用所述增益来修改所述语音子帧的能级。

    Dual-Pulse Excited Linear Prediction For Speech Coding
    88.
    发明申请
    Dual-Pulse Excited Linear Prediction For Speech Coding 有权
    用于语音编码的双脉冲激励线性预测

    公开(公告)号:US20080154586A1

    公开(公告)日:2008-06-26

    申请号:US11942066

    申请日:2007-11-19

    申请人: Yang Gao

    发明人: Yang Gao

    IPC分类号: G10L19/12 G10L11/06

    CPC分类号: G10L19/10

    摘要: The invention proposed a Dual-Pulse Excitation Model; wherein two pulses of each pair of pulses are always adjacent each other. Only one position index for each pair of pulses needs to be sent to the decoder, which saves bits to code all pulse positions. The magnitudes of each pair of pulses have limited number of patterns. Because the two pulses are adjacent each other, each pair of pulses with different magnitudes can produce different high-pass and/or low-pass effect. Since the magnitudes have enough variation, it is possible to assign the candidate positions of each pair of pulses within a small range in order to save the searching complexity.

    摘要翻译: 本发明提出了双脉冲激励模型; 其中每对脉冲的两个脉冲总是彼此相邻。 需要将每对脉冲对的一个位置索引发送到解码器,从而保存位以对所有脉冲位置进行编码。 每对脉冲的幅度数量有限。 由于两个脉冲彼此相邻,所以具有不同幅度的每对脉冲可以产生不同的高通和/或低通效应。 由于幅度具有足够的变化,因此可以将每对脉冲的候选位置分配在小范围内,以便节省搜索的复杂度。

    Pitch determination for speech processing
    89.
    发明申请
    Pitch determination for speech processing 审中-公开
    语音处理的音调确定

    公开(公告)号:US20080147384A1

    公开(公告)日:2008-06-19

    申请号:US12069973

    申请日:2008-02-14

    申请人: Huan-Yu Su Yang Gao

    发明人: Huan-Yu Su Yang Gao

    IPC分类号: G10L11/04

    摘要: There is provided a method of selecting a pitch lag value for a portion of a speech signal, the method comprising: computing a weighted correlation function of the portion of the speech signal for a range of delay times, wherein the weighting of the correlation function depends on both the delay time and a characteristic of one or more previous portions of the speech signal; and selecting the pitch lag value based on a delay time from the range of delay times that maximizes the weighted correlation function.

    摘要翻译: 提供了一种为语音信号的一部分选择音调滞后值的方法,所述方法包括:在延迟时间范围内计算语音信号部分的加权相关函数,其中相关函数的权重取决于 在延迟时间和语音信号的一个或多个先前部分的特性上; 以及从加权相关函数最大化的延迟时间的范围内,基于延迟时间选择音调滞后值。

    TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES
    90.
    发明申请
    TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES 审中-公开
    四氢吡咯并[3,4-D]吡嗪和相关的类似物

    公开(公告)号:US20080051387A1

    公开(公告)日:2008-02-28

    申请号:US11759929

    申请日:2007-06-07

    摘要: Tetrahydropyrido[3,4-d]pyrimidines and related analogues are provided, of the formula: in which variables are as described herein, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are partially useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

    摘要翻译: 四氢吡啶并[3,4-d]嘧啶和相关的类似物具有下式:其中变量如本文所述,以及其制备和使用方法。 这样的化合物通常可用于在体内或体外调节配体与组胺H3受体的结合,并且部分可用于治疗人类,驯养的伴侣动物和家畜中的各种疾病。 提供药物组合物和治疗方法,以及使用这种配体检测组胺H3受体的方法(例如,受体定位研究)。