摘要:
Amino methyl imidazoles of Formula I are provided: wherein R, R1, R2, R3, R4, R5, and R6 are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.
摘要:
Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues of the formula (I): are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
摘要:
In an embodiment, a method of frequency domain post-processing is disclosed. The method includes applying adaptive modification gain factor to each frequency coefficient, and determining gain factors based on Local Masking Magnitude and Local Masked Magnitude.
摘要:
Low bit rate audio coding such as BWE algorithm often encounters conflict goal of achieving high time resolution and high frequency resolution at the same time. In order to achieve best possible quality, input signal can be first classified into fast signal and slow signal. This invention focuses on classifying signal into fast signal and slow signal, based on at least one of the following parameters or a combination of the following parameters: spectral sharpness, temporal sharpness, pitch correlation (pitch gain), and/or spectral envelope variation. This classification information can help to choose different BWE algorithms, different coding algorithms, and different postprocessing algorithms respectively for fast signal and slow signal.
摘要:
A process identifies one or more roles associated with a target server. The process also identifies one or more services associated with each role and identifies one or more ports associated with each role. The identified ports associated with the role are presented to a user. The user is requested to select among the identified ports associated with the role.
摘要:
In order to achieve the best improvement of ITU G.711 related codec perceptual quality, perceptual weighting controlling parameter(s) should be at least adaptive to relative quantization error statistics or adaptive to signal level. When the relative quantization error statistics are larger or the signal level is lower, the perceptual weighting should be “stronger”, which means α in (5) is smaller; when the relative quantization error statistics are smaller or the signal level is larger, the perceptual weighting should be “weaker”, which means α in (5) is larger.
摘要:
There is provided a method of reducing effect of noise producing artifacts in silence areas of a speech signal for use by a speech decoding system. The method comprises obtaining a plurality of incoming samples of a speech subframe; summing an absolute value of an energy level for each of the plurality of incoming samples to generate a total input level (gain_in); smoothing the total input level to generate a smoothed level (Level_in_sm); determining that the speech subframe is in a silence area based on the total input level, the smoothed level and a spectral tilt parameter; defining a gain using k1*(Level_in_sm/1024)+(1−k1), where K1 is a function of the spectral tilt parameter; and modifying an energy level of the speech subframe using the gain.
摘要:
The invention proposed a Dual-Pulse Excitation Model; wherein two pulses of each pair of pulses are always adjacent each other. Only one position index for each pair of pulses needs to be sent to the decoder, which saves bits to code all pulse positions. The magnitudes of each pair of pulses have limited number of patterns. Because the two pulses are adjacent each other, each pair of pulses with different magnitudes can produce different high-pass and/or low-pass effect. Since the magnitudes have enough variation, it is possible to assign the candidate positions of each pair of pulses within a small range in order to save the searching complexity.
摘要:
There is provided a method of selecting a pitch lag value for a portion of a speech signal, the method comprising: computing a weighted correlation function of the portion of the speech signal for a range of delay times, wherein the weighting of the correlation function depends on both the delay time and a characteristic of one or more previous portions of the speech signal; and selecting the pitch lag value based on a delay time from the range of delay times that maximizes the weighted correlation function.
摘要:
Tetrahydropyrido[3,4-d]pyrimidines and related analogues are provided, of the formula: in which variables are as described herein, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are partially useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).